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Ligand · RIS

RIS · 1-hydroxy-2-(3-pyridinyl)ethylidene bis-phosphonic acid

RIS, 1-hydroxy-2-(3-pyridinyl)ethylidene bis-phosphonic acid (C7 H11 N O7 P2, 283.1 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
RIS
Formula
C7 H11 N O7 P2
Class
ligand
Structures
4
PDB entries
3

Binding sites

RIS in 4 structures; the first of them:

  • 7KJ9 · Wild-type epi-isozizaene synthase: complex with 3 Mg2+ and risedronate · RIS A405 · binds PHE95, PHE96, ASP99, TYR172, ARG194, THR197, PHE198, TRP203 and 6 more
  • 8SU2 · F96H epi-Isozizaene Synthase: complex with 3 Mg2+ and risedronate · RIS A403 · binds PHE95, HIS96, ASP99, TYR172, ARG194, THR197, PHE198, TRP203 and 6 more
  • 7KJ9 · Wild-type epi-isozizaene synthase: complex with 3 MG2+ and risedronate · RIS A405 · binds PHE95, PHE96, ASP99, TYR172, ARG194, THR197, PHE198, ASN240 and 5 more
  • 7KJD · F96M epi-isozizaene synthase: complex with 3 MG2+ and risedronate · RIS A405 · binds PHE95, MET96, ASP99, TYR172, ARG194, THR197, PHE198, ASN240 and 5 more

Residues it binds most

PHE 4, ARG 4, TYR 4, ASN 4, ASP 4, GLU 4, LYS 4, SER 4, THR 4, TRP 2 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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