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Ligand · DMA

DMA · Dimethylallyl diphosphate

DMA, Dimethylallyl diphosphate (C5 H12 O7 P2, 246.1 g/mol), in the MolNFT structures on GenesisL1: bound in 15 records (10 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found…

Component
DMA
Formula
C5 H12 O7 P2
Class
ligand
Structures
15
PDB entries
10

Binding sites

DMA in 15 structures; the first of them:

  • 5XK7 · Crystal structure of Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp.… · DMA B303 · binds PHE180, ARG211, TYR212, GLY213, LEU214, LEU7, PRO8, ASP9 and 9 more
  • 5YNT · Crystal structure of an aromatic prenyltransferase FAMD1 from Fischerella ambigua UTEX… · DMA A401 · binds ARG46, ARG60, ASP106, LYS115, TRP117, ASP159, ASN166, TYR168 and 6 more
  • 5YNU · Crystal structure of an aromatic prenyltransferase FAMD1 from Fischerella ambigua UTEX… · DMA B401 · binds ARG46, ARG60, ASP106, LYS115, TRP117, ASN166, TYR168, GLU207 and 3 more
  • 6M34 · Structural and functional insights into an Archaeal synthase · DMA A302 · binds THR144, PHE148, LEU164, SER168, SER171, ILE172, LYS266, MET269 and 3 more
  • 7RNI · Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen · DMA B505 · binds LYS164, TYR166, TYR200, HIS201, HIS248, TYR251, ARG291, LYS294 and 1 more
  • 5XK7 · Crystal structure of isosesquilavandulyl diphosphate synthase from streptomyces sp.… · DMA B303 · binds PHE180, ARG211, TYR212, GLY213, LEU7, PRO8, ASP9, THR51 and 8 more
  • 5XK9 · Crystal structure of isosesquilavandulyl diphosphate synthase from streptomyces sp.… · DMA A502 · binds LEU7, PRO8, ASP9, THR51, ASN57, ARG60, ARG163, ARG169 and 1 more
  • 5YNT · Crystal structure of an aromatic prenyltransferase FAMD1 from fischerella ambigua utex… · DMA A401 · binds ARG46, ARG60, LYS115, ASN166, TYR168, ARG221, TYR225, LYS275
  • 5YNU · Crystal structure of an aromatic prenyltransferase FAMD1 from fischerella ambigua utex… · DMA B401 · binds ARG46, ARG60, ASP106, LYS115, TRP117, ASN166, TYR168, GLU207 and 3 more
  • 6M34 · Structural and functional insights into an archaeal synthase · DMA A302 · binds THR144, LEU164, SER168, SER171, ILE172, LYS266, MET269, ASN270 and 2 more
  • 6QLG · Crystal structure of anubix (PADA1) in complex with FMN and dimethylallyl pyrophosphate · DMA C301 · binds MET106, SER111, SER112, GLY113, SER114, ARG144, LYS151
  • 7CAV · Versatile cis-prenyltransferase MM_0014 from methanosarcina mazei (crystal type… · DMA A301 · binds ILE16, PRO17, ASP18, PHE60, GLY61, THR63, ASN66, ARG69 and 6 more
  • 7RNI · Discovery of an anion-dependent farnesyltransferase inhibitor from a phenotypic screen · DMA B505 · binds LYS164, TYR166, TYR200, HIS201, HIS248, TYR251, ARG291, LYS294 and 1 more

Residues it binds most

ARG 44, SER 29, ASN 38, TYR 31, GLY 29, PHE 29, ASP 30, LEU 24, THR 26, PRO 27 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • POP · Pyrophosphate 2-
  • PO4 · Phosphate ion
  • SO4 · Sulfate ion
  • GOL · Glycerol
  • IMD · Imidazole
  • 60I · [4-[[3-(2,2-dimethylpropyl)-1~{H}-benzimidazol-2-yl]methyl]piperazin-1-yl]-(1,3,5-trimethylpyrazol-4-yl)methanone
  • 8XL · 3-[(Z)-2-isocyanoethenyl]-1H-indole
  • ACE · Acetyl group
  • MPG · [(Z)-octadec-9-enyl] (2R)-2,3-bis(oxidanyl)propanoate
  • ZN · Zinc ion
  • LDA · Lauryl dimethylamine-N-oxide

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