UniProt P11362
Fibroblast growth factor receptor 1 (P11362)
Fibroblast growth factor receptor 1 (UniProt P11362), EC 2.7.10.1: 131 experimental structures and 1 predicted model on GenesisL1, 30 ligands bound, 102 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P11362
- Protein
- Fibroblast growth factor receptor 1
- EC
- 2.7.10.1
- Experimental structures
- 131
- Predicted models
- 1
- Ligands
- 30
- Pockets
- 102 · 23 records with a druggable one
Structures
132 records of P11362 in the MolNFT archive: 131 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AGW | Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 in complex… | x-ray diffraction | A, B | — | — |
| 1AGW | Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 in complex… | x-ray diffraction | A, B | — | — |
| 1CVS | Crystal structure of a dimeric FGF2-FGFR1 complex | x-ray diffraction | C, D | — | — |
| 1CVS | Crystal structure of a dimeric FGF2-FGFR1 complex | x-ray diffraction | C, D | — | — |
| 1EVT | Crystal structure of FGF1 in complex with the extracellular ligand binding domain of FGF receptor 1… | x-ray diffraction | C, D | — | — |
| 1EVT | Crystal structure of FGF1 in complex with the extracellular ligand binding domain of FGF receptor 1… | x-ray diffraction | C, D | — | — |
| 1FGI | Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 in complex… | x-ray diffraction | A, B | — | — |
| 1FGI | Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 in complex… | x-ray diffraction | A, B | — | — |
| 1FGK | Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 | x-ray diffraction | A, B | — | — |
| 1FGK | Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 | x-ray diffraction | A, B | — | — |
| 1FQ9 | Crystal structure of a ternary FGF2-FGFR1-heparin complex | x-ray diffraction | C, D | — | — |
| 1FQ9 | Crystal structure of a ternary FGF2-FGFR1-heparin complex | x-ray diffraction | C, D | — | — |
| 1XR0 | Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors | solution nmr | A | — | — |
| 1XR0 | Structural basis of snt ptb domain interactions with distinct neurotrophic receptors | solution nmr | A | — | — |
| 2CR3 | Solution structure of the first Ig-like domain of human fibroblast growth factor receptor 1 | solution nmr | A | — | — |
| 2CR3 | Solution structure of the first ig-like domain of human fibroblast growth factor receptor 1 | solution nmr | A | — | — |
| 2FGI | Crystal structure of the tyrosine kinase domain of FGF receptor 1 in complex with inhibitor PD173074 | x-ray diffraction | A, B | — | — |
| 2FGI | Crystal structure of the tyrosine kinase domain of FGF receptor 1 in complex with inhibitor PD173074 | x-ray diffraction | A, B | — | — |
| 3C4F | FGFR TYROSINE KINASE DOMAIN IN COMPLEX WITH 3-(3-methoxybenzyl)-7-azaindole | x-ray diffraction | A, B | — | — |
| 3C4F | Fgfr tyrosine kinase domain in complex with 3-(3-methoxybenzyl)-7- azaindole | x-ray diffraction | A, B | — | — |
| 3DPK | cFMS tyrosine kinase in complex with a pyridopyrimidi inhibitor | x-ray diffraction | A | — | — |
| 3DPK | Cfms tyrosine kinase in complex with a pyridopyrimidinone inhibitor | x-ray diffraction | A | — | — |
| 3GQI | Crystal Structure of activated receptor tyrosine kinase in complex with substrates | x-ray diffraction | A | — | — |
| 3GQI | Crystal structure of activated receptor tyrosine kinase in complex with substrates | x-ray diffraction | A | — | — |
| 3GQL | Crystal Structure of activated receptor tyrosine kinase in complex with substrates | x-ray diffraction | A, B, C | — | — |
| 3GQL | Crystal structure of activated receptor tyrosine kinase in complex with substrates | x-ray diffraction | A, B, C | — | — |
| 3JS2 | Crystal structure of minimal kinase domain of fibroblast growth factor receptor 1 in complex with… | x-ray diffraction | A, B | — | — |
| 3JS2 | Crystal structure of minimal kinase domain of fibroblast growth factor receptor 1 in complex with… | x-ray diffraction | A, B | — | — |
| 3KRJ | cFMS tyrosine kinase in complex with 4-Cyano-1H-imidazole-2-carboxylic acid… | x-ray diffraction | A | — | — |
| 3KRJ | Cfms tyrosine kinase in complex with 4-cyano-1H-imidazole-2-carboxylic acid… | x-ray diffraction | A | — | — |
| 3KRL | cFMS Tyrosine kinase in complex with 5-Cyano-furan-2-carboxylic acid… | x-ray diffraction | A | — | — |
| 3KRL | Cfms tyrosine kinase in complex with 5-cyano-furan-2-carboxylic acid… | x-ray diffraction | A | — | — |
| 3KXX | Structure of the mutant Fibroblast Growth Factor receptor 1 | x-ray diffraction | A, B, C, D | — | — |
| 3KXX | Structure of the mutant fibroblast growth factor receptor 1 | x-ray diffraction | A, B, C, D | — | — |
| 3KY2 | Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain | x-ray diffraction | A, B | — | — |
| 3KY2 | Crystal structure of fibroblast growth factor receptor 1 kinase domain | x-ray diffraction | A, B | — | — |
| 3OJV | Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand… | x-ray diffraction | C, D | — | — |
| 3OJV | Crystal structure of FGF1 complexed with the ectodomain of FGFR1C exhibiting an ordered ligand… | x-ray diffraction | C, D | — | — |
| 3RHX | Crystal structure of the catalytic domain of FGFR1 kinase in complex with ARQ 069 | x-ray diffraction | B, A | — | — |
| 3RHX | Crystal structure of the catalytic domain of FGFR1 kinase in complex with arq 069 | x-ray diffraction | B, A | — | — |
| 3TT0 | Co-structure of Fibroblast Growth Factor Receptor 1 kinase domain with… | x-ray diffraction | A, B | — | — |
| 3TT0 | Co-structure of fibroblast growth factor receptor 1 kinase domain with… | x-ray diffraction | A, B | — | — |
| 4F63 | Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4F63 | Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4F64 | Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4F64 | Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4F65 | Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4F65 | Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4NK9 | Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4NK9 | Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4NKA | Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4NKA | Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4NKS | Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4NKS | Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4RWI | Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M), apo | x-ray diffraction | A, B | — | — |
| 4RWI | Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M), apo | x-ray diffraction | A, B | — | — |
| 4RWJ | Crystal Structure of FGFR1 (C488A, C584S) in complex with AZD4547… | x-ray diffraction | A, B | — | — |
| 4RWJ | Crystal structure of FGFR1 (C488A, C584S) in complex with AZD4547 (N… | x-ray diffraction | A, B | — | — |
| 4RWK | Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M) in complex with… | x-ray diffraction | A, B | — | — |
| 4RWK | Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M) in complex with… | x-ray diffraction | A, B | — | — |
72 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 33 records
- CL · Chloride ion · in 4 records
- TZ0 · 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one · in 4 records
- 960 · 1-[(6-chloroimidazo[1,2-b]pyridazin-3-yl)sulfonyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridine · in 2 records
- 9ES · N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl) carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide · in 2 records
- 9K5 · [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 3-fluorosulfonylbenzoate · in 2 records
- 9K8 · [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 4-ethyl-3-fluorosulfonyl-benzoate · in 2 records
- AXU · 4-azanyl-3-(3,5-dimethyl-1-benzofuran-2-yl)-2-phenyl-6~{H}-pyrazolo[3,4-d]pyridazin-7-one · in 2 records
- MK9 · N-(3-{[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-{[4-(diethylamino)butyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)prop-2-enamide · in 2 records
- O1Y · N-{3-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl) carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-1-(2-hydroxyethyl)-1H-pyrazol-4-yl}prop-2-enamide · in 2 records
- O21 · N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl) carbamoyl][3-(4-methylpiperazin-1-yl) propyl]amino}pyrimidin-4-yl)amino]phenyl}prop-2-enamide · in 2 records
- WP1 · 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide · in 2 records
- XL6 · N-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl) methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide · in 2 records
- YY4 · 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one · in 2 records
- YY5 · 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-[(propan-2-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one · in 2 records
- YY6 · 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one · in 2 records
- YY7 · 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one · in 2 records
- YY9 · 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one · in 2 records
- 42I · N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]benzamide · in 1 record
- 466 · N-[6-(3-ethoxyphenyl)-1H-indazol-3-yl]benzamide · in 1 record
- 47I · 4-[3-(4-piperazin-4-ium-1-ylphenyl)-1H-indazol-6-yl]phenol · in 1 record
- 5SF · ~{N}'-(3,5-dimethoxyphenyl)-~{N}'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-~{N}-propan-2-yl-ethane-1,2-diamine · in 1 record
- A1AV2 · (3P)-5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-3-{6-[6-(methanesulfonyl)-2,6-diazaspiro[3.3]heptan-2-yl]pyridin-3-yl}-1H-indazole · in 1 record
- A1LVQ · Cxf007 · in 1 record
- A1LWW · 5-azanyl-3-[2-[4,6-bis(fluoranyl)-2-methyl-3~{H}-benzimidazol-5-yl]ethynyl]-1-[[3-(prop-2-enoylamino)phenyl]methyl]pyrazole-4-carboxamide · in 1 record
- A1LY1 · Tasurgratinib · in 1 record
- I9W · 2,2-dimethyl-N-[(6-methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}pyridin-2-yl)carbamoyl]propanamide · in 1 record
- LEV · 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide · in 1 record
- NA · Sodium ion · in 1 record
- UKI · Sulfatinib · in 1 record
Experiment against prediction
- 5FLF chain C against the predicted model P11362: TM-score 0.98, RMSD 1.03 Å
- 5FLF chain C against the predicted model P11362: TM-score 0.98, RMSD 1.03 Å
- 8YKI chain A against the predicted model P11362: TM-score 0.97, RMSD 1.16 Å
- 5FLF chain A against the predicted model P11362: TM-score 0.97, RMSD 1.29 Å
- 5FLF chain A against the predicted model P11362: TM-score 0.97, RMSD 1.29 Å
- 5UQ0 chain A against the predicted model P11362: TM-score 0.97, RMSD 1.33 Å
- 5UQ0 chain A against the predicted model P11362: TM-score 0.97, RMSD 1.33 Å
- 5FLF chain D against the predicted model P11362: TM-score 0.97, RMSD 1.23 Å
- 5FLF chain D against the predicted model P11362: TM-score 0.97, RMSD 1.23 Å
- 6C1B chain A against the predicted model P11362: TM-score 0.97, RMSD 1.29 Å
Elsewhere
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