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Ligand · 2K7

2K7 · N~4~-{3-[2-(3,4-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine

2K7, N~4~-{3-[2-(3,4-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine (C22 H25 N7 O3, 435.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
2K7
Formula
C22 H25 N7 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

2K7 in 2 structures; the first of them:

  • 4NKA · Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex… · 2K7 A805 · binds LEU484, GLY485, VAL492, ALA512, LYS514, LEU528, GLU531, ILE545 and 10 more
  • 4NKA · Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex… · 2K7 A805 · binds LEU484, GLY485, VAL492, ALA512, LYS514, LEU528, GLU531, ILE545 and 10 more

Residues it binds most

ALA 4, LEU 4, GLU 4, GLY 4, VAL 4, ARG 4, ASN 4, ASP 4, ILE 4, LYS 4 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol

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