UniProt P11086
Phenylethanolamine N-methyltransferase (P11086)
Phenylethanolamine N-methyltransferase (UniProt P11086): 85 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P11086
- Protein
- Phenylethanolamine N-methyltransferase
- Experimental structures
- 85
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 1 · 1 record with a druggable one
Structures
86 records of P11086 in the MolNFT archive: 85 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HNN | Crystal structure of human pnmt complexed with SK&F 29661 and ADOHCY(SAH) | x-ray diffraction | A, B | — | — |
| 1HNN | Crystal structure of human pnmt complexed with SK&F 29661 and ADOHCY(SAH) | x-ray diffraction | A, B | — | — |
| 1N7I | The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and… | x-ray diffraction | A, B | — | — |
| 1N7I | The structure of phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and… | x-ray diffraction | A, B | — | — |
| 1N7J | The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and… | x-ray diffraction | A, B | — | — |
| 1N7J | The structure of phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and… | x-ray diffraction | A, B | — | — |
| 1YZ3 | Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139 | x-ray diffraction | A, B | — | — |
| 1YZ3 | Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139 | x-ray diffraction | A, B | — | — |
| 2AN3 | Structure of PNMT with S-adenosyl-L-homocysteine and the semi-rigid analogue acceptor substrate… | x-ray diffraction | A, B | — | — |
| 2AN3 | Structure of pnmt with S-adenosyl-L-homocysteine and the semi-rigid analogue acceptor substrate… | x-ray diffraction | A, B | — | — |
| 2AN4 | Structure of PNMT complexed with S-adenosyl-L-homocysteine and the acceptor substrate octopamine | x-ray diffraction | A, B | — | — |
| 2AN4 | Structure of pnmt complexed with S-adenosyl-L-homocysteine and the acceptor substrate octopamine | x-ray diffraction | A, B | — | — |
| 2AN5 | Structure of human PNMT complexed with S-adenosyl-homocysteine and an inhibitor… | x-ray diffraction | A, B | — | — |
| 2AN5 | Structure of human pnmt complexed with S-adenosyl- homocysteine and an inhibitor… | x-ray diffraction | A, B | — | — |
| 2G70 | Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM) | x-ray diffraction | A, B | — | — |
| 2G70 | Structure of human pnmt in complex with inhibitor 3-hydroxymethyl-7- nitro-thiq and adomet (SAM) | x-ray diffraction | A, B | — | — |
| 2G71 | Structure of hPNMT with inhibitor 3-fluoromethyl-7-trifluoropropyl-THIQ and AdoHcy | x-ray diffraction | A, B | — | — |
| 2G71 | Structure of hpnmt with inhibitor 3-fluoromethyl-7-trifluoropropyl- thiq and adohcy | x-ray diffraction | A, B | — | — |
| 2G72 | Structure of hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ and AdoMet | x-ray diffraction | A, B | — | — |
| 2G72 | Structure of hpnmt with inhibitor 3-fluoromethyl-7- thiomorpholinosulfonamide-thiq and adomet | x-ray diffraction | A, B | — | — |
| 2G8N | Structure of hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy | x-ray diffraction | A, B | — | — |
| 2G8N | Structure of hpnmt with inhibitor 3-hydroxymethyl-7-(N-4- chlorophenylaminosulfonyl)-thiq and adohcy | x-ray diffraction | A, B | — | — |
| 2OBF | Structure of K57A hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ and… | x-ray diffraction | A, B | — | — |
| 2OBF | Structure of K57A hpnmt with inhibitor 3-hydroxymethyl-7-(N-4- chlorophenylaminosulfonyl)-thiq and… | x-ray diffraction | A, B | — | — |
| 2ONY | Structure of hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy | x-ray diffraction | A, B | — | — |
| 2ONY | Structure of hpnmt with inhibitor 7-(N-4-chlorophenylaminosulfonyl)- thiq and adohcy | x-ray diffraction | A, B | — | — |
| 2ONZ | Structure of K57A hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy | x-ray diffraction | A, B | — | — |
| 2ONZ | Structure of K57A hpnmt with inhibitor 7-(N-4- chlorophenylaminosulfonyl)-thiq and adohcy | x-ray diffraction | A, B | — | — |
| 2OPB | Structure of K57A hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ and AdoHcy | x-ray diffraction | A, B | — | — |
| 2OPB | Structure of K57A hpnmt with inhibitor 3-fluoromethyl-7- thiomorpholinosulfonamide-thiq and adohcy | x-ray diffraction | A, B | — | — |
| 3HCA | Crystal Structure of E185Q hPNMT in Complex With Octopamine and AdoHcy | x-ray diffraction | A, B | — | — |
| 3HCA | Crystal structure of E185Q hpnmt in complex with octopamine and adohcy | x-ray diffraction | A, B | — | — |
| 3HCB | Crystal Structure of hPNMT in Complex With Noradrenochrome and AdoHcy | x-ray diffraction | A, B | — | — |
| 3HCB | Crystal structure of hpnmt in complex with noradrenochrome and adohcy | x-ray diffraction | A, B | — | — |
| 3HCC | Crystal Structure of hPNMT in Complex With anti-9-amino-5-(trifluromethyl) benzonorbornene and… | x-ray diffraction | A, B | — | — |
| 3HCC | Crystal structure of hpnmt in complex with anti-9-amino-5- (trifluromethyl) benzonorbornene and… | x-ray diffraction | A, B | — | — |
| 3HCD | Crystal Structure of hPNMT in Complex With Noradrenaline and AdoHcy | x-ray diffraction | A, B | — | — |
| 3HCD | Crystal structure of hpnmt in complex with noradrenaline and adohcy | x-ray diffraction | A, B | — | — |
| 3HCE | Crystal Structure of E185D hPNMT in Complex With Octopamine and AdoHcy | x-ray diffraction | A, B | — | — |
| 3HCE | Crystal structure of E185D hpnmt in complex with octopamine and adohcy | x-ray diffraction | A, B | — | — |
| 3HCF | Crystal Structure of hPNMT in Complex With 3-trifluoromethyl phenylethanolamine and AdoHcy | x-ray diffraction | A, B | — | — |
| 3HCF | Crystal structure of hpnmt in complex with 3-trifluoromethyl phenylethanolamine and adohcy | x-ray diffraction | A, B | — | — |
| 3KPJ | Crystal Structure of hPNMT in Complex AdoHcy and Bound Phosphate | x-ray diffraction | A, B | — | — |
| 3KPJ | Crystal structure of hpnmt in complex adohcy and bound phosphate | x-ray diffraction | A, B | — | — |
| 3KPU | Crystal Structure of hPNMT in Complex AdoHcy and 4-quinolinol | x-ray diffraction | A, B | — | — |
| 3KPU | Crystal structure of hpnmt in complex adohcy and 4-quinolinol | x-ray diffraction | A, B | — | — |
| 3KPV | Crystal Structure of hPNMT in Complex AdoHcy and Adenine | x-ray diffraction | A, B | — | — |
| 3KPV | Crystal structure of hpnmt in complex adohcy and adenine | x-ray diffraction | A, B | — | — |
| 3KPW | Crystal Structure of hPNMT in Complex AdoHcy and 1-Aminoisoquinoline | x-ray diffraction | A, B | — | — |
| 3KPW | Crystal structure of hpnmt in complex adohcy and 1-aminoisoquinoline | x-ray diffraction | A, B | — | — |
| 3KPY | Crystal Structure of hPNMT in Complex AdoHcy and 6-Chlorooxindole | x-ray diffraction | A, B | — | — |
| 3KPY | Crystal structure of hpnmt in complex adohcy and 6-chlorooxindole | x-ray diffraction | A, B | — | — |
| 3KQM | Crystal Structure of hPNMT in Complex AdoHcy and 4-Bromo-1H-imidazole | x-ray diffraction | A, B | — | — |
| 3KQM | Crystal structure of hpnmt in complex adohcy and 4-bromo-1H-imidazole | x-ray diffraction | A, B | — | — |
| 3KQO | Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine | x-ray diffraction | A, B | — | — |
| 3KQO | Crystal structure of hpnmt in complex adohcy and 6-chloropurine | x-ray diffraction | A, B | — | — |
| 3KQP | Crystal Structure of hPNMT in Complex AdoHcy and 6-Aminoquinoline | x-ray diffraction | A, B | — | — |
| 3KQP | Crystal structure of hpnmt in complex adohcy and 6-aminoquinoline | x-ray diffraction | A, B | — | — |
| 3KQQ | Crystal Structure of hPNMT in Complex AdoHcy and 2-Hydroxynicotinic acid | x-ray diffraction | A, B | — | — |
| 3KQQ | Crystal structure of hpnmt in complex adohcy and 2-hydroxynicotinic acid | x-ray diffraction | A, B | — | — |
26 records more on the page itself.
Ligands
Experiment against prediction
- 4MQ4 chain A against the predicted model P11086: TM-score 1.00, RMSD 0.35 Å
- 4MIK chain B against the predicted model P11086: TM-score 1.00, RMSD 0.38 Å
- 7TWU chain B against the predicted model P11086: TM-score 1.00, RMSD 0.41 Å
- 4MIK chain A against the predicted model P11086: TM-score 1.00, RMSD 0.40 Å
- 4MQ4 chain B against the predicted model P11086: TM-score 1.00, RMSD 0.42 Å
- 2G70 chain B against the predicted model P11086: TM-score 0.99, RMSD 0.38 Å
- 3HCB chain A against the predicted model P11086: TM-score 0.99, RMSD 0.38 Å
- 4DM3 chain A against the predicted model P11086: TM-score 0.99, RMSD 0.39 Å
- 2ONY chain B against the predicted model P11086: TM-score 0.99, RMSD 0.41 Å
- 3KQT chain A against the predicted model P11086: TM-score 0.99, RMSD 0.39 Å
Elsewhere
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