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Ligand · HNT

HNT · [(3R)-7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol

HNT, [(3R)-7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol (C10 H12 N2 O3, 208.2 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
HNT
Formula
C10 H12 N2 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

HNT in 2 structures; the first of them:

  • 2G70 · Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet… · HNT A5001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, LYS57, PHE182, GLU185 and 9 more
  • 2G70 · Structure of human pnmt in complex with inhibitor 3-hydroxymethyl-7- nitro-thiq and… · HNT A5001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, LYS57, PHE182, GLU185 and 9 more

Residues it binds most

VAL 6, TYR 4, GLU 6, ALA 4, ARG 6, ASP 6, ASN 4, LYS 4, MET 4, PHE 4 (residue and the binding sites it lines).

Found with

  • SAM · S-adenosylmethionine
  • PO4 · Phosphate ion

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