GL1X · GenesisL1 explorer

Ligand · F21

F21 · (3R)-3-(fluoromethyl)-7-(thiomorpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

F21, (3R)-3-(fluoromethyl)-7-(thiomorpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline (C14 H19 F N2 O2 S2, 330.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues…

Component
F21
Formula
C14 H19 F N2 O2 S2
Class
ligand
Structures
4
PDB entries
2

Binding sites

F21 in 4 structures; the first of them:

  • 2G72 · Structure of hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ and… · F21 A4001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, LYS57, TYR85 and 11 more
  • 2OPB · Structure of K57A hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ… · F21 A4001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, ALA57, TYR85 and 10 more
  • 2G72 · Structure of hpnmt with inhibitor 3-fluoromethyl-7- thiomorpholinosulfonamide-thiq and… · F21 A4001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, LYS57, TYR85 and 11 more
  • 2OPB · Structure of K57A hpnmt with inhibitor 3-fluoromethyl-7- thiomorpholinosulfonamide-thiq… · F21 A4001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, ALA57, TYR85 and 10 more

Residues it binds most

TYR 8, VAL 8, ALA 8, ARG 8, ASN 8, ASP 8, GLU 8, GLY 8, MET 8, PHE 8 (residue and the binding sites it lines).

Found with

  • SAH · S-adenosyl-L-homocysteine
  • SAM · S-adenosylmethionine
  • PO4 · Phosphate ion

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.