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Ligand · TMJ

TMJ · N-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

TMJ, N-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (C15 H15 Cl N2 O2 S, 322.8 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
TMJ
Formula
C15 H15 Cl N2 O2 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

TMJ in 4 structures; the first of them:

  • 2ONY · Structure of hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy · TMJ A2001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, LYS57, LEU58 and 9 more
  • 2ONZ · Structure of K57A hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy · TMJ A2001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, ALA57, LEU58 and 9 more
  • 2ONY · Structure of hpnmt with inhibitor 7-(N-4-chlorophenylaminosulfonyl)- thiq and adohcy · TMJ A2001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, LYS57, LEU58 and 9 more
  • 2ONZ · Structure of K57A hpnmt with inhibitor 7-(N-4- chlorophenylaminosulfonyl)-thiq and adohcy · TMJ A2001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, ALA57, LEU58 and 9 more

Residues it binds most

TYR 6, VAL 6, ALA 4, ARG 6, ASN 6, ASP 6, GLU 6, GLY 6, LEU 6, MET 6 (residue and the binding sites it lines).

Found with

  • SAH · S-adenosyl-L-homocysteine
  • PO4 · Phosphate ion

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