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Ligand · F83

F83 · (3R)-N-(4-chlorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

F83, (3R)-N-(4-chlorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (C16 H17 Cl N2 O3 S, 352.8 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues…

Component
F83
Formula
C16 H17 Cl N2 O3 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

F83 in 4 structures; the first of them:

  • 2G8N · Structure of hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ… · F83 A2001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, LYS57, LEU58 and 12 more
  • 2OBF · Structure of K57A hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-T… · F83 A2001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, ALA57, LEU58 and 12 more
  • 2G8N · Structure of hpnmt with inhibitor 3-hydroxymethyl-7-(N-4- chlorophenylaminosulfonyl)-thiq… · F83 A2001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, LYS57, LEU58 and 12 more
  • 2OBF · Structure of K57A hpnmt with inhibitor 3-hydroxymethyl-7-(N-4… · F83 A2001 · binds TYR35, ASN39, TYR40, ARG44, VAL53, GLY54, ALA57, LEU58 and 12 more

Residues it binds most

TYR 8, VAL 8, ALA 8, GLY 8, ARG 8, ASN 8, ASP 8, GLU 8, LEU 8, MET 8 (residue and the binding sites it lines).

Found with

  • SAH · S-adenosyl-L-homocysteine

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