UniProt P10964
DNA-directed RNA polymerase I subunit RPA190 (P10964)
DNA-directed RNA polymerase I subunit RPA190 (UniProt P10964), EC 2.7.7.6: 64 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 599 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P10964
- Protein
- DNA-directed RNA polymerase I subunit RPA190
- EC
- 2.7.7.6
- Experimental structures
- 64
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 599 · 46 records with a druggable one
Structures
65 records of P10964 in the MolNFT archive: 64 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4C2M | Structure of RNA polymerase I at 2.8 A resolution | x-ray diffraction | A, P | ZN | 17 (best 0.84) |
| 4C2M | Structure of RNA polymerase I at 2.8 a resolution | x-ray diffraction | A, P | ZN | 17 (best 0.84) |
| 4C3H | Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93 | x-ray diffraction | A | ZN | 16 (best 0.83) |
| 4C3H | Structure of 14-subunit RNA polymerase I at 3.27 a resolution, crystal form C2-93 | x-ray diffraction | A | ZN | 16 (best 0.83) |
| 4C3I | Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100 | x-ray diffraction | A | SO4, ZN, MG | 15 (best 0.84) |
| 4C3I | Structure of 14-subunit RNA polymerase I at 3.0 a resolution, crystal form C2-100 | x-ray diffraction | A | — | — |
| 4C3J | Structure of 14-subunit RNA polymerase I at 3.35 A resolution, crystal form C2-90 | x-ray diffraction | A | ZN | 16 (best 0.82) |
| 4C3J | Structure of 14-subunit RNA polymerase I at 3.35 a resolution, crystal form C2-90 | x-ray diffraction | A | ZN | 16 (best 0.82) |
| 5G5L | RNA polymerase I-RRN3 complex at 4.8 a resolution | electron microscopy | A | ZN | 13 (best 0.83) |
| 5LMX | Monomeric RNA polymerase I at 4.9 A resolution | electron microscopy | A | ZN | 10 (best 0.86) |
| 5LMX | Monomeric RNA polymerase I at 4.9 a resolution | electron microscopy | A | ZN | 10 (best 0.86) |
| 5M3F | Yeast RNA polymerase I elongation complex at 3.8A | electron microscopy | A | ZN, MG | 15 (best 0.84) |
| 5M3F | Yeast RNA polymerase I elongation complex at 3.8A | electron microscopy | A | ZN, MG | 15 (best 0.84) |
| 5M3M | Free monomeric RNA polymerase I at 4.0A resolution | electron microscopy | A | ZN | 13 (best 0.84) |
| 5M3M | Free monomeric RNA polymerase I at 4.0A resolution | electron microscopy | A | ZN | 13 (best 0.84) |
| 5M5W | RNA Polymerase I open complex | electron microscopy | A | ZN | 13 (best 0.86) |
| 5M5W | RNA polymerase I open complex | electron microscopy | A | ZN | 13 (best 0.86) |
| 5M5X | RNA Polymerase I elongation complex 1 | electron microscopy | A | ZN | 11 (best 0.84) |
| 5M5X | RNA polymerase I elongation complex 1 | electron microscopy | A | ZN | 11 (best 0.84) |
| 5M5Y | RNA Polymerase I elongation complex 2 | electron microscopy | A | ZN | 11 (best 0.82) |
| 5M5Y | RNA polymerase I elongation complex 2 | electron microscopy | A | ZN | 11 (best 0.82) |
| 5M64 | RNA Polymerase I elongation complex with A49 tandem winged helix domain | electron microscopy | A | ZN | 14 (best 0.88) |
| 5M64 | RNA polymerase I elongation complex with A49 tandem winged helix domain | electron microscopy | A | ZN | 14 (best 0.88) |
| 5N5Y | Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation III) | electron microscopy | A | ZN | 10 (best 0.83) |
| 5N5Y | Cryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation III) | electron microscopy | A | ZN | 10 (best 0.83) |
| 5N5Z | Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation II) | electron microscopy | A | ZN | 10 (best 0.82) |
| 5N5Z | Cryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation II) | electron microscopy | A | ZN | 10 (best 0.82) |
| 5N60 | Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation I) | electron microscopy | A | ZN | 12 (best 0.83) |
| 5N60 | Cryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation I) | electron microscopy | A | ZN | 12 (best 0.83) |
| 5N61 | RNA polymerase I initially transcribing complex | electron microscopy | A | ZN, MG | 10 (best 0.84) |
| 5OA1 | RNA polymerase I pre-initiation complex | electron microscopy | A | ZN | 15 (best 0.83) |
| 5OA1 | RNA polymerase I pre-initiation complex | electron microscopy | A | ZN | 15 (best 0.83) |
| 5W5Y | RNA polymerase I initial transcribing complex | electron microscopy | A | ZN | — |
| 5W64 | RNA polymerase I initial transcribing complex state 1 | electron microscopy | A | ZN | — |
| 5W65 | RNA polymerase I initial transcribing complex state 2 | electron microscopy | A | ZN | — |
| 5W66 | RNA polymerase I initial transcribing complex state 3 | electron microscopy | A | ZN | — |
| 6H67 | Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (CPD) | electron microscopy | A | ZN, MG | 16 (best 0.84) |
| 6H67 | Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (cpd) | electron microscopy | A | ZN, MG | — |
| 6H68 | Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (CPD) with… | electron microscopy | A | ZN | 12 (best 0.85) |
| 6H68 | Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (cpd) with… | electron microscopy | A | ZN | — |
| 6HKO | Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP | electron microscopy | A | MG, ZN, G2P | 15 (best 0.82) |
| 6HKO | Yeast RNA polymerase I elongation complex bound to nucleotide analog gmpcpp | electron microscopy | A | MG, ZN | — |
| 6HLQ | Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP | electron microscopy | A | ZN, MG, G2P | 17 (best 0.83) |
| 6HLQ | Yeast RNA polymerase I* elongation complex bound to nucleotide analog gmpcpp | electron microscopy | A | ZN, MG | — |
| 6HLR | Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused) | electron microscopy | A | MG, ZN, G2P | 17 (best 0.82) |
| 6HLR | Yeast RNA polymerase I elongation complex bound to nucleotide analog gmpcpp (core focused) | electron microscopy | A | MG, ZN | — |
| 6HLS | Yeast apo RNA polymerase I* | electron microscopy | A | ZN | 16 (best 0.82) |
| 6HLS | Yeast apo RNA polymerase I* | electron microscopy | A | ZN | — |
| 6RQH | RNA Polymerase I Closed Conformation 1 (CC1) | electron microscopy | A | — | 8 (best 0.84) |
| 6RQH | RNA polymerase I closed conformation 1 (CC1) | electron microscopy | A | — | — |
| 6RQL | RNA Polymerase I Closed Conformation 2 (CC2) | electron microscopy | A | — | 10 (best 0.85) |
| 6RQL | RNA polymerase I closed conformation 2 (CC2) | electron microscopy | A | — | — |
| 6RQT | RNA Polymerase I-tWH-Rrn3-DNA | electron microscopy | A | ZN | 11 (best 0.85) |
| 6RQT | RNA polymerase I-twh-RRN3-DNA | electron microscopy | A | ZN | — |
| 6RRD | RNA Polymerase I Pre-initiation complex DNA opening intermediate 1 | electron microscopy | A | — | 11 (best 0.85) |
| 6RRD | RNA polymerase I pre-initiation complex DNA opening intermediate 1 | electron microscopy | A | — | — |
| 6RUI | RNA Polymerase I Pre-initiation complex DNA opening intermediate 2 | electron microscopy | A | — | 11 (best 0.83) |
| 6RUI | RNA polymerase I pre-initiation complex DNA opening intermediate 2 | electron microscopy | A | — | — |
| 6RUO | RNA Polymerase I Open Complex conformation 1 | electron microscopy | A | ZN | 11 (best 0.85) |
| 6RUO | RNA polymerase I open complex conformation 1 | electron microscopy | A | ZN | — |
5 records more on the page itself.
Ligands
Experiment against prediction
- 5N61 chain A against the predicted model P10964: TM-score 0.97, RMSD 2.25 Å
- 5W5Y chain A against the predicted model P10964: TM-score 0.97, RMSD 2.32 Å
- 5W65 chain A against the predicted model P10964: TM-score 0.97, RMSD 2.32 Å
- 5W66 chain A against the predicted model P10964: TM-score 0.97, RMSD 2.36 Å
- 6RWE chain A against the predicted model P10964: TM-score 0.97, RMSD 2.38 Å
- 6RWE chain A against the predicted model P10964: TM-score 0.97, RMSD 2.38 Å
- 6HLR chain A against the predicted model P10964: TM-score 0.97, RMSD 2.30 Å
- 6HLR chain A against the predicted model P10964: TM-score 0.97, RMSD 2.30 Å
- 6HLQ chain A against the predicted model P10964: TM-score 0.97, RMSD 2.28 Å
- 6HLQ chain A against the predicted model P10964: TM-score 0.97, RMSD 2.28 Å
Elsewhere
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