UniProt P0A8V4
DNA-directed RNA polymerase subunit beta (P0A8V4)
DNA-directed RNA polymerase subunit beta (UniProt P0A8V4), EC 2.7.7.6: 161 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 1,133 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P0A8V4
- Protein
- DNA-directed RNA polymerase subunit beta
- EC
- 2.7.7.6
- Experimental structures
- 161
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 1,133 · 103 records with a druggable one
Structures
162 records of P0A8V4 in the MolNFT archive: 161 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4YG2 | X-ray crystal structur of Escherichia coli RNA polymerase sigma70 holoenzyme | x-ray diffraction | C, I | — | — |
| 4YG2 | X-ray crystal structur of escherichia COLI RNA polymerase SIGMA70 holoenzyme | x-ray diffraction | C, I | — | — |
| 5EZK | RNA polymerase model placed by Molecular replacement into X-ray diffraction map of DNA-bound RNA… | x-ray diffraction | C | — | — |
| 5EZK | RNA polymerase model placed by molecular replacement into X-ray diffraction MAP of DNA-bound RNA… | x-ray diffraction | C | — | — |
| 6GOV | Structure of THE RNA POLYMERASE LAMBDA-BASED ANTITERMINATION COMPLEX | electron microscopy | X | — | — |
| 6GOV | Structure of the RNA polymerase lambda-based antitermination complex | electron microscopy | X | — | — |
| 6N62 | Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA | x-ray diffraction | C | — | — |
| 6N62 | Escherichia COLI RNA polymerase SIGMA70-holoenzyme bound to upstream fork promoter DNA | x-ray diffraction | C | — | — |
| 6OMF | CryoEM structure of SigmaS-transcription initiation complex with activator Crl | electron microscopy | C | — | 13 (best 0.83) |
| 6OMF | Cryoem structure of sigmas-transcription initiation complex with activator crl | electron microscopy | C | — | — |
| 6OUL | Cryo-EM structure of Escherichia coli RNAP polymerase bound to rpsTP2 promoter DNA | electron microscopy | I | 1N7 | 15 (best 0.84) |
| 6OUL | Cryo-EM structure of escherichia COLI rnap polymerase bound to RPSTP2 promoter DNA | electron microscopy | I | 1N7 | — |
| 6P1K | Cryo-EM structure of Escherichia coli sigma70 bound RNAP polymerase holoenzyme | electron microscopy | I | — | 12 (best 0.81) |
| 6P1K | Cryo-EM structure of escherichia COLI SIGMA70 bound rnap polymerase holoenzyme | electron microscopy | I | — | — |
| 6PSQ | Escherichia coli RNA polymerase closed complex (TRPc) with TraR and rpsT P2 promoter | electron microscopy | I | ZN, 1N7 | 14 (best 0.81) |
| 6PSQ | Escherichia COLI RNA polymerase closed complex (trpc) with trar and rpst P2 promoter | electron microscopy | I | 1N7 | — |
| 6PSR | Escherichia coli RNA polymerase promoter unwinding intermediate (TRPi1) with TraR and rpsT P2… | electron microscopy | I | 1N7 | 13 (best 0.82) |
| 6PSR | Escherichia COLI RNA polymerase promoter unwinding intermediate (TRPI1) with trar and rpst P2… | electron microscopy | I | 1N7 | — |
| 6PSS | Escherichia coli RNA polymerase promoter unwinding intermediate (TRPi1.5a) with TraR and mutant… | electron microscopy | I | — | 16 (best 0.82) |
| 6PSS | Escherichia COLI RNA polymerase promoter unwinding intermediate (TRPI1.5A) with trar and mutant… | electron microscopy | I | — | — |
| 6PST | Escherichia coli RNA polymerase promoter unwinding intermediate (TRPi1.5b) with TraR and mutant… | electron microscopy | I | 1N7 | 14 (best 0.84) |
| 6PST | Escherichia COLI RNA polymerase promoter unwinding intermediate (TRPI1.5B) with trar and mutant… | electron microscopy | I | 1N7 | — |
| 6PSU | Escherichia coli RNA polymerase promoter unwinding intermediate (TRPi2) with TraR and rpsT P2… | electron microscopy | I | 1N7 | 13 (best 0.85) |
| 6PSU | Escherichia COLI RNA polymerase promoter unwinding intermediate (TRPI2) with trar and rpst P2… | electron microscopy | I | 1N7 | — |
| 6PSV | Escherichia coli RNA polymerase promoter unwinding intermediate (TpreRPo) with TraR and rpsT P2… | electron microscopy | I | 1N7 | 15 (best 0.82) |
| 6PSV | Escherichia COLI RNA polymerase promoter unwinding intermediate (tprerpo) with trar and rpst P2… | electron microscopy | I | 1N7 | — |
| 6PSW | Escherichia coli RNA polymerase promoter unwinding intermediate (TRPo) with TraR and rpsT P2… | electron microscopy | I | 1N7 | 16 (best 0.82) |
| 6PSW | Escherichia COLI RNA polymerase promoter unwinding intermediate (trpo) with trar and rpst P2… | electron microscopy | I | 1N7 | — |
| 6TQN | rrn anti-termination complex without S4 | electron microscopy | X | — | 15 (best 0.84) |
| 6TQN | Rrn anti-termination complex without S4 | electron microscopy | X | — | — |
| 6TQO | rrn anti-termination complex | electron microscopy | X | — | 13 (best 0.85) |
| 6TQO | Rrn anti-termination complex | electron microscopy | X | — | — |
| 6UTW | E. coli sigma-S transcription initiation complex with a 4-nt RNA (Fresh" crystal)" | x-ray diffraction | CCC | MG, DPO | 14 (best 0.83) |
| 6UTX | E. coli sigma-S transcription initiation complex with an empty bubble (Old" crystal)" | x-ray diffraction | CCC | — | 15 (best 0.84) |
| 6UTY | E. coli sigma-S transcription initiation complex with a mismatching CTP (Old" crystal soaked with… | x-ray diffraction | CCC | MG, CTP | 14 (best 0.83) |
| 6UTZ | E. coli sigma-S transcription initiation complex with a 6-nt RNA (Fresh" crystal soaked with CTP… | x-ray diffraction | CCC | MG, DPO | 16 (best 0.84) |
| 6UU0 | E. coli sigma-S transcription initiation complex with a 3-nt RNA and a mismatching GTP ("Fresh"… | x-ray diffraction | CCC | MG, GTP | 16 (best 0.84) |
| 6UU1 | E. coli sigma-S transcription initiation complex with a 4-nt RNA and a CTP ("Fresh" crystal soaked… | x-ray diffraction | CCC | CTP | 16 (best 0.84) |
| 6UU2 | E. coli sigma-S transcription initiation complex with 3-nt RNA (Old" crystal soaked with GTP and… | x-ray diffraction | CCC | MG, GTP | 17 (best 0.82) |
| 6UU3 | E. coli sigma-S transcription initiation complex with a 4-nt RNA and a CTP ("Old" crystal soaked… | x-ray diffraction | CCC | MG, CTP, D4M | 15 (best 0.86) |
| 6UU4 | E. coli sigma-S transcription initiation complex with a 3-nt RNA (old" crystal soaked with GTP and… | x-ray diffraction | CCC | MG, GTP | 17 (best 0.82) |
| 6UU5 | E. coli sigma-S transcription initiation complex with a 6-nt RNA ("Old" crystal soaked with GTP… | x-ray diffraction | CCC | MG, DPO | 16 (best 0.87) |
| 6UU6 | E. coli sigma-S transcription initiation complex with a 4-nt RNA and a UTP ("Old" crystal soaked… | x-ray diffraction | CCC | UTP, MG | 16 (best 0.80) |
| 6UU7 | E. coli sigma-S transcription initiation complex with a 6-nt RNA and an NTP ("Old" crystal soaked… | x-ray diffraction | CCC | MG, DG3 | 17 (best 0.86) |
| 6UU8 | E. coli mutant sigma-S transcription initiation complex with a 7-nt RNA ("Fresh" mutant crystal… | x-ray diffraction | CCC | MG, DPO | 16 (best 0.84) |
| 6UU9 | E. coli mutant sigma-S transcription initiation complex with an 8-nt RNA ("Fresh" mutant crystal… | x-ray diffraction | CCC | MG, DPO | 17 (best 0.84) |
| 6UUA | E. coli sigma-S transcription initiation complex with a mismatching CTP (Fresh" crystal soaked with… | x-ray diffraction | CCC | MG, CTP | 15 (best 0.81) |
| 6UUB | E. coli sigma-S transcription initiation complex with a mismatching UTP (Fresh" crystal soaked with… | x-ray diffraction | CCC | MG, UTP | 17 (best 0.82) |
| 6UUC | E. coli sigma-S transcription initiation complex with a 3-nt RNA and a mismatching ATP (Fresh"… | x-ray diffraction | CCC | MG, ATP | 14 (best 0.82) |
| 6VJS | Escherichia coli RNA polymerase and ureidothiophene-2-carboxylic acid complex | x-ray diffraction | C, H | QZY | 16 (best 0.87) |
| 6VJS | Escherichia COLI RNA polymerase and ureidothiophene-2-carboxylic acid complex | x-ray diffraction | C, H | QZY | — |
| 6VU3 | Cryo-EM structure of Escherichia coli transcription-translation complex A (TTC-A) containing mRNA… | electron microscopy | AA | — | 1 (best 0.84) |
| 6VYR | Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 18 nt long mRNA… | electron microscopy | AA | — | 2 (best 0.83) |
| 6VYS | Escherichia coli transcription-translation complex A1 (TTC-A1) containing a 21 nt long mRNA spacer… | electron microscopy | AA | — | 3 (best 0.84) |
| 6VYT | Escherichia coli transcription-translation complex A2 (TTC-A2) containing a 15 nt long mRNA spacer… | electron microscopy | AA | — | 1 (best 0.84) |
| 6VYU | Escherichia coli transcription-translation complex C2 (TTC-C2) containing a 27 nt long mRNA spacer | electron microscopy | AA | — | 1 (best 0.84) |
| 6VYW | Escherichia coli transcription-translation complex C3 (TTC-C3) containing mRNA with a 27 nt long… | electron microscopy | AA | — | 1 (best 0.84) |
| 6VYX | Escherichia coli transcription-translation complex C4 (TTC-C4) containing mRNA with a 21 nt long… | electron microscopy | AA | — | 2 (best 0.84) |
| 6VYY | Escherichia coli transcription-translation complex C5 (TTC-C5) containing mRNA with a 21 nt long… | electron microscopy | AA | — | 2 (best 0.86) |
| 6VYZ | Escherichia coli transcription-translation complex C6 (TTC-C6) containing mRNA with a 21 nt long… | electron microscopy | AA | — | 2 (best 0.84) |
102 records more on the page itself.
Ligands
- 1N7 · Chapso · in 28 records
- MG · Magnesium ion · in 15 records
- DPO · Diphosphate · in 5 records
- CTP · Cytidine-5'-triphosphate · in 4 records
- GTP · Guanosine-5'-triphosphate · in 3 records
- QZY · 3-{[benzyl(ethyl)carbamoyl]amino}-5-(4-phenoxyphenyl) thiophene-2-carboxylic acid · in 2 records
- UTP · Uridine 5'-triphosphate · in 2 records
- 4QM · (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- D4M · [(5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl]methyl dihydrogen phosphate · in 1 record
- DG3 · 2'-3'-dideoxyguanosine-5'-triphosphate · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 6X2F chain I against the predicted model P0A8V4: TM-score 0.99, RMSD 1.09 Å
- 6X2N chain I against the predicted model P0A8V4: TM-score 0.99, RMSD 1.09 Å
- 6VYX chain AA against the predicted model P0A8V4: TM-score 0.99, RMSD 1.09 Å
- 6VYZ chain AA against the predicted model P0A8V4: TM-score 0.99, RMSD 1.09 Å
- 6VYY chain AA against the predicted model P0A8V4: TM-score 0.99, RMSD 1.09 Å
- 6VZ3 chain AA against the predicted model P0A8V4: TM-score 0.99, RMSD 1.09 Å
- 6XII chain AA against the predicted model P0A8V4: TM-score 0.99, RMSD 1.19 Å
- 6WMU chain C against the predicted model P0A8V4: TM-score 0.99, RMSD 1.23 Å
- 6UU8 chain CCC against the predicted model P0A8V4: TM-score 0.99, RMSD 1.25 Å
- 7UWH chain I against the predicted model P0A8V4: TM-score 0.99, RMSD 1.27 Å
Elsewhere
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