UniProt P09874
Poly [ADP-ribose] polymerase 1 (P09874)
Poly [ADP-ribose] polymerase 1 (UniProt P09874), EC 2.4.2.-, 2.4.2.30: 162 experimental structures on GenesisL1, 45 ligands bound, 249 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P09874
- Protein
- Poly [ADP-ribose] polymerase 1
- EC
- 2.4.2.-, 2.4.2.30
- Experimental structures
- 162
- Predicted models
- 0
- Ligands
- 45
- Pockets
- 249 · 30 records with a druggable one
Structures
162 records of P09874 in the MolNFT archive: 162 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1UK0 | Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor | x-ray diffraction | A, B | — | — |
| 1UK0 | Crystal structure of catalytic domain of human POLY(ADP- ribose) polymerase with a novel inhibitor | x-ray diffraction | A, B | — | — |
| 1UK1 | Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor | x-ray diffraction | A, B | — | — |
| 1UK1 | Crystal structure of human POLY(ADP-ribose) polymerase complexed with a potent inhibitor | x-ray diffraction | A, B | — | — |
| 1WOK | Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase complexed with a… | x-ray diffraction | A, B, C, D | — | — |
| 1WOK | Crystal structure of catalytic domain of human POLY(ADP-ribose) polymerase complexed with a… | x-ray diffraction | A, B, C, D | — | — |
| 2COK | Solution structure of BRCT domain of poly(ADP-ribose) polymerase-1 | solution nmr | A | — | — |
| 2COK | Solution structure of brct domain of POLY(ADP-ribose) polymerase-1 | solution nmr | A | — | — |
| 2CR9 | Solution structure of WGR domain of poly(ADP-ribose) polymerase-1 | solution nmr | A | — | — |
| 2CR9 | Solution structure of wgr domain of POLY(ADP-ribose) polymerase-1 | solution nmr | A | — | — |
| 2CS2 | Solution structure of the second Zn-finger domain of poly(ADP-ribose) polymerase-1 | solution nmr | A | — | — |
| 2CS2 | Solution structure of the second zn-finger domain of POLY(ADP-ribose) polymerase-1 | solution nmr | A | — | — |
| 2JVN | Domain C of human PARP-1 | solution nmr | A | — | — |
| 2JVN | Domain C of human parp-1 | solution nmr | A | — | — |
| 2L30 | Human PARP-1 zinc finger 1 | solution nmr | A | — | — |
| 2L30 | Human parp-1 zinc finger 1 | solution nmr | A | — | — |
| 2L31 | Human PARP-1 zinc finger 2 | solution nmr | A | — | — |
| 2L31 | Human parp-1 zinc finger 2 | solution nmr | A | — | — |
| 2N8A | 1H, 13C and 15N chemical shift assignments and solution structure for PARP-1 F1F2 domains in… | solution nmr | A | — | — |
| 2N8A | 1H, 13C and 15N chemical shift assignments and solution structure for parp-1 F1F2 domains in… | solution nmr | A | — | — |
| 2RCW | PARP complexed with A620223 | x-ray diffraction | A | — | — |
| 2RCW | Parp complexed with A620223 | x-ray diffraction | A | — | — |
| 2RD6 | PARP complexed with A861695 | x-ray diffraction | A | — | — |
| 2RD6 | Parp complexed with A861695 | x-ray diffraction | A | — | — |
| 2RIQ | Crystal Structure of the Third Zinc-binding domain of human PARP-1 | x-ray diffraction | A | — | — |
| 2RIQ | Crystal structure of the third zinc-binding domain of human parp-1 | x-ray diffraction | A | — | — |
| 3GJW | PARP complexed with A968427 | x-ray diffraction | A | — | — |
| 3GJW | Parp complexed with A968427 | x-ray diffraction | A | — | — |
| 3GN7 | PARP complexed with A861696 | x-ray diffraction | A | — | — |
| 3GN7 | Parp complexed with A861696 | x-ray diffraction | A | — | — |
| 3L3L | PARP complexed with A906894 | x-ray diffraction | A | — | — |
| 3L3L | Parp complexed with A906894 | x-ray diffraction | A | — | — |
| 3L3M | PARP complexed with A927929 | x-ray diffraction | A | — | — |
| 3L3M | Parp complexed with A927929 | x-ray diffraction | A | — | — |
| 3OD8 | Human PARP-1 zinc finger 1 (Zn1) bound to DNA | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3OD8 | Human parp-1 zinc finger 1 (ZN1) bound to DNA | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3ODA | Human PARP-1 zinc finger 1 (Zn1) bound to DNA | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3ODA | Human parp-1 zinc finger 1 (ZN1) bound to DNA | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3ODC | Human PARP-1 zinc finger 2 (Zn2) bound to DNA | x-ray diffraction | A, B | — | — |
| 3ODC | Human parp-1 zinc finger 2 (ZN2) bound to DNA | x-ray diffraction | A, B | — | — |
| 3ODE | Human PARP-1 zinc finger 2 (Zn2) bound to DNA | x-ray diffraction | A, B | — | — |
| 3ODE | Human parp-1 zinc finger 2 (ZN2) bound to DNA | x-ray diffraction | A, B | — | — |
| 4AV1 | Crystal structure of the human PARP-1 DNA binding domain in complex with DNA | x-ray diffraction | A, B, C, D | — | — |
| 4AV1 | Crystal structure of the human parp-1 DNA binding domain in complex with DNA | x-ray diffraction | A, B, C, D | — | — |
| 4DQY | Structure of Human PARP-1 bound to a DNA double strand break | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4DQY | Structure of human parp-1 bound to a DNA double strand break | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4GV7 | Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328 | x-ray diffraction | A, B, C, D | — | — |
| 4GV7 | Human ARTD1 (PARP1) - catalytic domain in complex with inhibitor ME0328 | x-ray diffraction | A, B, C, D | — | — |
| 4HHY | Crystal structure of PARP catalytic domain in complex with novel inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4HHY | Crystal structure of parp catalytic domain in complex with novel inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4HHZ | Crystal structure of PARP catalytic domain in complex with novel inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4HHZ | Crystal structure of parp catalytic domain in complex with novel inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4L6S | PARP complexed with benzo[1,4]oxazin-3-one inhibitor | x-ray diffraction | A, B | — | — |
| 4L6S | Parp complexed with BENZO[1,4]OXAZIN-3-one inhibitor | x-ray diffraction | A, B | — | — |
| 4OPX | Structure of Human PARP-1 bound to a DNA double strand break in complex with… | x-ray diffraction | A, C, D, F | — | — |
| 4OPX | Structure of human parp-1 bound to a DNA double strand break in complex with… | x-ray diffraction | A, C, D, F | — | — |
| 4OQA | Structure of Human PARP-1 bound to a DNA double strand break in complex with… | x-ray diffraction | A, C, D, F | — | — |
| 4OQA | Structure of human parp-1 bound to a DNA double strand break in complex with… | x-ray diffraction | A, C, D, F | — | — |
| 4OQB | Structure of Human PARP-1 bound to a DNA double strand break in complex with… | x-ray diffraction | A, C, D, F | — | — |
| 4OQB | Structure of human parp-1 bound to a DNA double strand break in complex with… | x-ray diffraction | A, C, D, F | — | — |
102 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 37 records
- ZN · Zinc ion · in 9 records
- UHB · 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide · in 6 records
- 09L · 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one · in 4 records
- 78P · (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium · in 4 records
- CL · Chloride ion · in 4 records
- FRU · beta-D-fructofuranose · in 3 records
- GLC · alpha-D-glucopyranose · in 3 records
- 3JD · 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide · in 2 records
- 6WX · 1-[[4-fluoranyl-3-(3-oxidanylidene-4-propyl-piperazin-1-yl)carbonyl-phenyl]methyl]quinazoline-2,4-dione · in 2 records
- 6WZ · 1-[[4-fluoranyl-3-[(3R)-3-methyl-4-[2,2,2-tris(fluoranyl)ethyl]piperazin-1-yl]carbonyl-phenyl]methyl]quinazoline-2,4-dione · in 2 records
- 6X2 · 1-[[4-fluoranyl-3-[(3R)-3-methyl-4-propyl-piperazin-1-yl]carbonyl-phenyl]methyl]quinazoline-2,4-dione · in 2 records
- 7U6 · 2-piperazin-1-ylcarbonyl-1H-benzimidazole-4-carboxamide · in 2 records
- 7U9 · 2-[(3R)-3-azanylpyrrolidin-1-yl]carbonyl-1H-benzimidazole-4-carboxamide · in 2 records
- 7UL · 1-[[4-fluoranyl-3-[4-[2,2,2-tris(fluoranyl) ethyl]piperazin-1-yl]carbonyl-phenyl]methyl]quinazoline-2,4-dione · in 2 records
- 8E6 · 6-fluoranyl-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide · in 2 records
- KYJ · (2Z)-2-[(4-{[2-(1H-benzimidazol-2-yl) ethyl]carbamoyl}phenyl)methylidene]-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide · in 2 records
- KYM · (2Z)-2-{[4-(3-cyclopropyl-5,6-dihydro[1,2,4]triazolo[4, 3-a]pyrazine-7(8H)-carbonyl)phenyl]methylidene}-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide · in 2 records
- KYV · 2-({4-[4-(1H-benzimidazol-2-yl)piperazine-1-carbonyl]phenyl}methyl)-3-hydroxy-1-benzofuran-7-carboxamide · in 2 records
- KYY · 2-{[3-fluoro-4-(1H-tetrazol-5-yl)phenyl]methyl}-3-hydroxy-1-benzofuran-7-carboxamide · in 2 records
- L1S · Methyl 2-{4-[4-(7-carbamoyl-1H-benzimidazol-2-yl) benzene-1-carbonyl]piperazin-1-yl}pyrimidine-5-carboxylate · in 2 records
- NI · Nickel (II) ion · in 2 records
- O3H · 2-[2-(4-pyridin-2-ylpiperazin-1-yl)ethylsulfanyl]-3~{H}-quinazolin-4-one · in 2 records
- UNU · Benzamide · in 2 records
- VKT · 7-[[4-(1,5-dimethylimidazol-2-yl)piperazin-1-yl]methyl]-3-ethyl-1~{H}-quinolin-2-one · in 2 records
- VKW · 8-chloranyl-2-[3-[4-(1,5-dimethylimidazol-2-yl) piperazin-1-yl]propyl]-3~{H}-quinazolin-4-one · in 2 records
- YH0 · 2-(4-{[2-(1H-benzimidazol-2-yl)ethyl]carbamoyl}phenyl)-1H-benzimidazole-7-carboxamide · in 2 records
- 1WI · 1-[[4-fluoranyl-3-(3-oxidanylidene-4-pentan-3-yl-piperazin-1-yl)carbonyl-phenyl]methyl]quinazoline-2,4-dione · in 1 record
- 2YQ · (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2, 4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one · in 1 record
- 4YR · N-[(3R)-1-(cyclopropylmethyl)pyrrolidin-3-yl]-5-[(2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)methyl]-2-fluorobenzamide · in 1 record
Elsewhere
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