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Ligand · FRQ

FRQ · 5-fluoro-1-[4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl]quinazoline-2,4(1H,3H)-dione

FRQ, 5-fluoro-1-[4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl]quinazoline-2,4(1H,3H)-dione (C23 H24 F N3 O2, 393.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues…

Component
FRQ
Formula
C23 H24 F N3 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

FRQ in 2 structures; the first of them:

  • 1UK1 · Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor · FRQ A501 · binds ASP766, LEU769, ASP770, TRP861, HIS862, GLY863, ARG878, ILE879 and 11 more
  • 1UK1 · Crystal structure of human POLY(ADP-ribose) polymerase complexed with a potent inhibitor · FRQ A501 · binds ASP766, LEU769, ASP770, TRP861, HIS862, GLY863, ARG878, ILE879 and 11 more

Residues it binds most

TYR 4, ALA 4, ASP 4, GLU 4, GLY 4, ARG 4, HIS 4, ILE 4, LEU 4, LYS 4 (residue and the binding sites it lines).

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