UHB · 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide

Binding sites

UHB in 8 structures; the first of them:

• 5DSY · Crystal structure of constitutively active PARP-2 · UHB A1001 · binds TRP414, HIS415, GLY416, SER417, ASN421, GLY424, ILE425, GLY429 and 9 more
• 6HXR · Human PARP16 (ARTD15) IN COMPLEX WITH EB-47 · UHB A301 · binds HIS152, GLY153, SER154, ASN158, SER161, ILE162, GLY166, LEU167 and 7 more
• 7AAB · Crystal structure of the catalytic domain of human PARP1 in complex with inhibitor EB-47 · UHB A1101 · binds ASP766, ASP770, TRP861, HIS862, GLY863, SER864, ASN868, GLY871 and 13 more
• 6HXR · Human PARP16 (ARTD15) in complex with eb-47 · UHB A301 · binds HIS152, GLY153, SER154, ASN158, SER161, ILE162, GLY166, LEU167 and 7 more
• 6TX3 · HPF1 bound to catalytic fragment of PARP2 · UHB B1001 · binds HIS415, GLY416, SER417, ASN421, GLY424, ILE425, GLY429, ARG431 and 8 more
• 6VKQ · Crystal structure of human parp-1 cat domain bound to inhibitor eb-47 · UHB A2001 · binds ASP766, LEU769, ASP770, HIS862, GLY863, SER864, ASN868, ILE872 and 11 more
• 7AAB · Crystal structure of the catalytic domain of human PARP1 in complex with inhibitor eb-47 · UHB A1101 · binds ASP766, ASP770, TRP861, HIS862, GLY863, SER864, ASN868, GLY871 and 9 more
• 7S6H · Human PARP1 DELTAV687-E688 bound to NAD+ analog eb-47 and to a DNA double strand break. · UHB B1102 · binds TRP861, HIS862, GLY863, SER864, ASN868, GLY871, ILE872, GLN875 and 10 more

Residues it binds most

GLY 19, TYR 19, SER 19, HIS 19, LEU 16, ASN 19, ILE 19, ARG 15, ASP 8, ALA 13 (residue and the binding sites it lines).

Found with

• SO4 · Sulfate ion
• ZN · Zinc ion
• EDO · 1,2-ethanediol