UniProt P08631
Tyrosine-protein kinase HCK (P08631)
Tyrosine-protein kinase HCK (UniProt P08631), EC 2.7.10.2: 78 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P08631
- Protein
- Tyrosine-protein kinase HCK
- EC
- 2.7.10.2
- Experimental structures
- 78
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 17 · 5 records with a druggable one
Structures
79 records of P08631 in the MolNFT archive: 78 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AD5 | Src family kinase hck-AMP-pnp complex | x-ray diffraction | A, B | — | — |
| 1AD5 | Src family kinase hck-AMP-pnp complex | x-ray diffraction | A, B | — | — |
| 1BU1 | Src family kinase hck SH3 domain | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1BU1 | Src family kinase hck SH3 domain | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1QCF | Crystal structure of hck in complex with a src family-selective tyrosine kinase inhibitor | x-ray diffraction | A | — | — |
| 1QCF | Crystal structure of hck in complex with a src family-selective tyrosine kinase inhibitor | x-ray diffraction | A | — | — |
| 2C0I | Src family kinase Hck with bound inhibitor A-420983 | x-ray diffraction | A, B | — | — |
| 2C0I | Src family kinase hck with bound inhibitor a-420983 | x-ray diffraction | A, B | — | — |
| 2C0O | Src family kinase Hck with bound inhibitor A-770041 | x-ray diffraction | A, B | — | — |
| 2C0O | Src family kinase hck with bound inhibitor a-770041 | x-ray diffraction | A, B | — | — |
| 2C0T | Src family kinase Hck with bound inhibitor A-641359 | x-ray diffraction | A, B | — | — |
| 2C0T | Src family kinase hck with bound inhibitor a-641359 | x-ray diffraction | A, B | — | — |
| 2HCK | Src family kinase hck-quercetin complex | x-ray diffraction | A, B | — | — |
| 2HCK | Src family kinase hck-quercetin complex | x-ray diffraction | A, B | — | — |
| 2HK5 | Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247 | x-ray diffraction | A | — | — |
| 2HK5 | Hck kinase in complex with lck targetted inhibitor pg-1009247 | x-ray diffraction | A | — | — |
| 2OI3 | NMR Structure Analysis of the Hematopoetic Cell Kinase SH3 Domain complexed with an artificial high… | solution nmr | A | — | — |
| 2OI3 | NMR structure analysis of the hematopoetic cell kinase SH3 domain complexed with an artificial high… | solution nmr | A | — | — |
| 2OJ2 | NMR Structure Analysis of the Hematopoetic Cell Kinase SH3 Domain complexed with an artificial high… | solution nmr | A | — | — |
| 2OJ2 | NMR structure analysis of the hematopoetic cell kinase SH3 domain complexed with an artificial high… | solution nmr | A | — | — |
| 3HCK | NMR ensemble of the uncomplexed human HCK SH2 domain, 20 structures | solution nmr | A | — | — |
| 3HCK | NMR ensemble of the uncomplexed human hck SH2 domain, 20 structures | solution nmr | A | — | — |
| 3NHN | Crystal structure of the SRC-family kinase HCK SH3-SH2-linker regulatory region | x-ray diffraction | A | — | — |
| 3NHN | Crystal structure of the src-family kinase hck SH3-SH2-linker regulatory region | x-ray diffraction | A | — | — |
| 3RBB | HIV-1 NEF protein in complex with engineered HCK SH3 domain | x-ray diffraction | B, D | — | — |
| 3RBB | HIV-1 nef protein in complex with engineered hck SH3 domain | x-ray diffraction | B, D | — | — |
| 3REA | HIV-1 Nef protein in complex with engineered Hck-SH3 domain | x-ray diffraction | B, D | — | — |
| 3REA | HIV-1 nef protein in complex with engineered hck-SH3 domain | x-ray diffraction | B, D | — | — |
| 3REB | HIV-1 Nef protein in complex with engineered Hck-SH3 domain | x-ray diffraction | B, D | — | — |
| 3REB | HIV-1 nef protein in complex with engineered hck-SH3 domain | x-ray diffraction | B, D | — | — |
| 3VRY | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VRY | Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VRZ | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VRZ | Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS0 | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS0 | Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS1 | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS1 | Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS2 | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS2 | Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS3 | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS3 | Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS4 | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS4 | Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS5 | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS5 | Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS6 | Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor tert-butyl… | x-ray diffraction | A, B | — | — |
| 3VS6 | Crystal structure of hck complexed with a pyrazolo-pyrimidine inhibitor tert-butyl… | x-ray diffraction | A, B | — | — |
| 3VS7 | Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 3VS7 | Crystal structure of hck complexed with a pyrazolo-pyrimidine inhibitor… | x-ray diffraction | A, B | — | — |
| 4HCK | Human hck SH3 domain, NMR, 25 structures | solution nmr | A | — | — |
| 4HCK | Human hck SH3 domain, NMR, 25 structures | solution nmr | A | — | — |
| 4LUD | Crystal Structure of HCK in complex with the fluorescent compound SKF86002 | x-ray diffraction | A, B | — | — |
| 4LUD | Crystal structure of hck in complex with the fluorescent compound SKF86002 | x-ray diffraction | A, B | — | — |
| 4LUE | Crystal Structure of HCK in complex with 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxy… | x-ray diffraction | A, B | — | — |
| 4LUE | Crystal structure of hck in complex with 7-[trans-4-(4… | x-ray diffraction | A, B | — | — |
| 4ORZ | HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain | x-ray diffraction | A | — | — |
| 4ORZ | HIV-1 nef protein in complex with single domain antibody SDAB19 and an engineered hck SH3 domain | x-ray diffraction | A | — | — |
| 4U5W | Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2… | x-ray diffraction | B, D | — | — |
| 4U5W | Crystal structure of HIV-1 nef-SF2 core domain in complex with the src family kinase hck SH3-SH2… | x-ray diffraction | B, D | — | — |
19 records more on the page itself.
Ligands
- VSE · 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine · in 3 records
- OOO · ethyl (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanoate · in 1 record
- OOQ · (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]azaniumyl]-4-methyl-pentanoate · in 1 record
- OOS · (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanamide · in 1 record
- OOU · (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{N},4-dimethyl-pentanamide · in 1 record
- OOV · (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{N},~{N},4-trimethyl-pentanamide · in 1 record
- SCN · Thiocyanate ion · in 1 record
Experiment against prediction
- 4LUE chain B against the predicted model P08631: TM-score 0.99, RMSD 0.82 Å
- 4LUE chain B against the predicted model P08631: TM-score 0.99, RMSD 0.82 Å
- 3VRY chain B against the predicted model P08631: TM-score 0.99, RMSD 0.86 Å
- 3VRY chain B against the predicted model P08631: TM-score 0.99, RMSD 0.86 Å
- 3VS4 chain B against the predicted model P08631: TM-score 0.99, RMSD 0.90 Å
- 3VS4 chain B against the predicted model P08631: TM-score 0.99, RMSD 0.90 Å
- 1AD5 chain A against the predicted model P08631: TM-score 0.99, RMSD 0.90 Å
- 1AD5 chain A against the predicted model P08631: TM-score 0.99, RMSD 0.90 Å
- 4LUD chain B against the predicted model P08631: TM-score 0.99, RMSD 0.89 Å
- 4LUD chain B against the predicted model P08631: TM-score 0.99, RMSD 0.89 Å
Elsewhere
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