UniProt P08191
Protein FimH (P08191)
Protein FimH (UniProt P08191): 87 experimental structures and 1 predicted model on GenesisL1, 21 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08191
- Protein
- Protein FimH
- Experimental structures
- 87
- Predicted models
- 1
- Ligands
- 21
- Pockets
- 40 · 13 records with a druggable one
Structures
88 records of P08191 in the MolNFT archive: 87 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KIU | FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose | x-ray diffraction | B, D, F, H, J, L, N, P | — | — |
| 1KIU | Fimh adhesin Q133N mutant-fimc chaperone complex with methyl-alpha-D- mannose | x-ray diffraction | B, D, F, H, J, L, N, P | — | — |
| 1KLF | Fimh adhesin-fimc chaperone complex with D-mannose | x-ray diffraction | B, D, F, H, J, L, N, P | — | — |
| 1KLF | Fimh adhesin-fimc chaperone complex with D-mannose | x-ray diffraction | B, D, F, H, J, L, N, P | — | — |
| 1QUN | X-ray structure of the fimc-fimh chaperone adhesin complex from uropathogenic E.COLI | x-ray diffraction | B, D, F, H, J, L, N, P | — | — |
| 1QUN | X-ray structure of the fimc-fimh chaperone adhesin complex from uropathogenic E.COLI | x-ray diffraction | B, D, F, H, J, L, N, P | — | — |
| 1TR7 | FimH adhesin receptor binding domain from uropathogenic E. coli | x-ray diffraction | B, A | — | — |
| 1TR7 | Fimh adhesin receptor binding domain from uropathogenic E. COLI | x-ray diffraction | B, A | — | — |
| 1UWF | 1.7 A resolution structure of the receptor binding domain of the FimH adhesin from uropathogenic E.… | x-ray diffraction | A | — | — |
| 1UWF | 1.7 a resolution structure of the receptor binding domain of the fimh adhesin from uropathogenic E.… | x-ray diffraction | A | — | — |
| 1ZE3 | Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain… | x-ray diffraction | H | — | — |
| 1ZE3 | Crystal structure of the ternary complex of fimd (N- terminal domain) with fimc and the pilin… | x-ray diffraction | H | — | — |
| 2VCO | Crystal structure of the fimbrial adhesin FimH in complex with its high-mannose epitope | x-ray diffraction | A, B | — | — |
| 2VCO | Crystal structure of the fimbrial adhesin fimh in complex with its high-mannose epitope | x-ray diffraction | A, B | — | — |
| 3ZL1 | A thiazolyl-mannoside bound to FimH, monoclinic space group | x-ray diffraction | A, B | — | — |
| 3ZL1 | A thiazolyl-mannoside bound to fimh, monoclinic space group | x-ray diffraction | A, B | — | — |
| 3ZL2 | A thiazolyl-mannoside bound to FimH, orthorhombic space group | x-ray diffraction | A | — | — |
| 3ZL2 | A thiazolyl-mannoside bound to fimh, orthorhombic space group | x-ray diffraction | A | — | — |
| 4CSS | Crystal structure of FimH in complex with a sulfonamide biphenyl alpha D-mannoside | x-ray diffraction | A | — | — |
| 4CSS | Crystal structure of fimh in complex with a sulfonamide biphenyl alpha D-mannoside | x-ray diffraction | A | — | — |
| 4CST | Crystal structure of FimH in complex with 3'-Chloro-4'-(alpha-D-mannopyranosyloxy)-biphenyl-4-carbon… | x-ray diffraction | A | — | — |
| 4CST | Crystal structure of fimh in complex with 3'-chloro-4'-(alpha-D… | x-ray diffraction | A | — | — |
| 4J3O | Crystal structure of the FimD usher traversed by the pilus tip complex assembly composed of… | x-ray diffraction | H | — | — |
| 4J3O | Crystal structure of the fimd usher traversed by the pilus tip complex assembly composed of… | x-ray diffraction | H | — | — |
| 4LOV | Crystal structure of FimH in complex with Heptylmannoside | x-ray diffraction | A | — | — |
| 4LOV | Crystal structure of fimh in complex with heptylmannoside | x-ray diffraction | A | — | — |
| 4X50 | Crystal structure of FimH in complex with biphenyl alpha-D-mannopyranoside | x-ray diffraction | A, B | — | — |
| 4X50 | Crystal structure of fimh in complex with biphenyl alpha-D- mannopyranoside | x-ray diffraction | A, B | — | — |
| 4X5P | Crystal structure of FimH in complex with a benzoyl-amidophenyl alpha-D-mannopyranoside | x-ray diffraction | A | — | — |
| 4X5P | Crystal structure of fimh in complex with a benzoyl-amidophenyl alpha- D-mannopyranoside | x-ray diffraction | A | — | — |
| 4X5Q | Crystal structure of FimH in complex with 5-nitro-indolinylphenyl alpha-D-mannopyranoside | x-ray diffraction | A | — | — |
| 4X5Q | Crystal structure of fimh in complex with 5-nitro-indolinylphenyl alpha-D-mannopyranoside | x-ray diffraction | A | — | — |
| 4X5R | Crystal structure of FimH in complex with a squaryl-phenyl alpha-D-mannopyranoside derivative | x-ray diffraction | A, B, C | — | — |
| 4X5R | Crystal structure of fimh in complex with a squaryl-phenyl alpha-D- mannopyranoside derivative | x-ray diffraction | A, B, C | — | — |
| 4XO8 | Crystal structure of the FimH lectin domain from E.coli K12 in complex with heptyl… | x-ray diffraction | A, B | — | — |
| 4XO8 | Crystal structure of the fimh lectin domain from E.COLI K12 in complex with heptyl… | x-ray diffraction | A, B | — | — |
| 4XO9 | Crystal structure of a FimH*DsG complex from E.coli K12 in space group C2 | x-ray diffraction | A | — | — |
| 4XO9 | Crystal structure of a FIMH*DSG complex from E.COLI K12 in space group C2 | x-ray diffraction | A | — | — |
| 4XOA | Crystal structure of a FimH*DsG complex from E.coli K12 in space group P1 | x-ray diffraction | A, C, E, G | — | — |
| 4XOA | Crystal structure of a FIMH*DSG complex from E.COLI K12 in space group P1 | x-ray diffraction | A, C, E, G | — | — |
| 4XOB | Crystal structure of a FimH*DsF complex from E.coli K12 with bound heptyl alpha-D-mannopyrannoside | x-ray diffraction | A, C, E, G | — | — |
| 4XOB | Crystal structure of a FIMH*DSF complex from E.COLI K12 with bound heptyl alpha-D-mannopyrannoside | x-ray diffraction | A, C, E, G | — | — |
| 5ABZ | Complex of the FimH lectin with a C-linked naphtyl alpha-D-mannoside in soaked trigonal crystals at… | x-ray diffraction | A, B | — | — |
| 5ABZ | Complex of the fimh lectin with a C-linked naphtyl alpha-D-mannoside in soaked trigonal crystals at… | x-ray diffraction | A, B | — | — |
| 5CGB | Crystal structure of fimh in complex with heptyl alpha-D-septanoside | x-ray diffraction | A, B | — | — |
| 5F2F | Crystal structure of para-biphenyl-2-methyl-3', 5' di-methyl amide mannoside bound to FimH lectin… | x-ray diffraction | A | 5U7 | — |
| 5F2F | Crystal structure of para-biphenyl-2-methyl-3', 5' di-methyl amide mannoside bound to fimh lectin… | x-ray diffraction | A | — | — |
| 5F3F | Crystal structure of para-biphenyl-2-methyl-3'-methyl amide mannoside bound to FimH lectin domain | x-ray diffraction | A | 5US | — |
| 5F3F | Crystal structure of para-biphenyl-2-methyl-3'-methyl amide mannoside bound to fimh lectin domain | x-ray diffraction | A | — | — |
| 5JCQ | Crystal structure of the FimH lectin domain from E.coli K12 in complex with methyl… | x-ray diffraction | A, B | MMA, SO4 | 1 (best 0.55) |
| 5JCQ | Crystal structure of the fimh lectin domain from E.COLI K12 in complex with methyl… | x-ray diffraction | A, B | — | — |
| 5JCR | Crystal structure of the FimH lectin domain from E.coli K12 in complex with methyl… | x-ray diffraction | A, B | MMA | 1 (best 0.54) |
| 5JCR | Crystal structure of the fimh lectin domain from E.COLI K12 in complex with methyl… | x-ray diffraction | A, B | — | — |
| 5L4T | Crystal structure of FimH lectin domain in complex with 2-Deoxy-Heptylmannoside | x-ray diffraction | A, B | 6LS | 1 (best 0.60) |
| 5L4T | Crystal structure of fimh lectin domain in complex with 2-deoxy- heptylmannoside | x-ray diffraction | A, B | 6LS | — |
| 5L4U | Crystal structure of FimH lectin domain in complex with 2-Fluoro-Heptylmannoside | x-ray diffraction | A, B | 6KS | 1 (best 0.61) |
| 5L4U | Crystal structure of fimh lectin domain in complex with 2-fluoro- heptylmannoside | x-ray diffraction | A, B | 6KS | — |
| 5L4V | Crystal structure of FimH lectin domain in complex with 3-Deoxy-Heptylmannoside | x-ray diffraction | A, B, C | 6KW | — |
| 5L4V | Crystal structure of fimh lectin domain in complex with 3-deoxy- heptylmannoside | x-ray diffraction | A, B, C | 6KW | — |
| 5L4W | Crystal structure of FimH lectin domain in complex with 3-Fluoro-Heptylmannoside | x-ray diffraction | A, B, C | 6KH | 3 (best 0.63) |
28 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 11 records
- MAN · alpha-D-mannopyranose · in 5 records
- NI · Nickel (II) ion · in 5 records
- MMA · methyl alpha-D-mannopyranoside · in 4 records
- BMA · beta-D-mannopyranose · in 3 records
- FUC · alpha-L-fucopyranose · in 3 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
- 6K3 · heptyl 4-deoxy-4-fluoro-alpha-D-mannopyranoside · in 2 records
- 6KH · heptyl 3-fluoro-alpha-D-mannopyranoside · in 2 records
- 6KS · heptyl 2-fluoro-alpha-D-mannopyranoside · in 2 records
- 6KU · heptyl 4-deoxy-4-deoxy-alpha-D-mannopyranoside · in 2 records
- 6KW · heptyl 3-deoxy-alpha-D-mannopyranoside · in 2 records
- 6LS · heptyl 2-deoxy-alpha-D-mannopyranoside · in 2 records
- AH2 · 1-deoxy-alpha-D-mannopyranose · in 2 records
- EJK · 4-[3-chloranyl-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-phenyl]-2,3,5,6-tetrakis(fluoranyl)benzenecarbonitrile · in 2 records
- EJN · (2~{R},3~{S},4~{S},5~{S},6~{R})-2-(hydroxymethyl)-6-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]phenoxy]oxane-3, 4,5-triol · in 2 records
- XKA · [2-[[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]amino]-1,3-thiazol-5-yl]-(4-methyl-2-pyrazin-2-yl-1,3-thiazol-5-yl) methanone · in 2 records
- 5U7 · 5-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}1,~{N}3-dimethyl-benzene-1,3-dicarboxamide · in 1 record
- 5US · 3-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}-methyl-benzamide · in 1 record
- RLO · (2R,3S,4R,5S,6R)-2-(hydroxymethyl)-6-[(E)-3-quinolin-6-ylprop-2-enyl]oxane-3,4,5-triol · in 1 record
- SBQ · Methyl 3-[3-chloranyl-4-[(2~{R},3~{S},4~{S},5~{S}, 6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-phenyl]benzoate · in 1 record
Experiment against prediction
- 4XOA chain G against the predicted model P08191: TM-score 0.99, RMSD 0.46 Å
- 4XOA chain G against the predicted model P08191: TM-score 0.99, RMSD 0.46 Å
- 4XOA chain C against the predicted model P08191: TM-score 0.99, RMSD 0.47 Å
- 4XOA chain C against the predicted model P08191: TM-score 0.99, RMSD 0.47 Å
- 4XOA chain E against the predicted model P08191: TM-score 0.99, RMSD 0.48 Å
- 4XOA chain E against the predicted model P08191: TM-score 0.99, RMSD 0.48 Å
- 4XOA chain A against the predicted model P08191: TM-score 0.99, RMSD 0.50 Å
- 4XOA chain A against the predicted model P08191: TM-score 0.99, RMSD 0.50 Å
- 4XO9 chain A against the predicted model P08191: TM-score 0.99, RMSD 0.55 Å
- 4XO9 chain A against the predicted model P08191: TM-score 0.99, RMSD 0.55 Å
Elsewhere
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