UniProt P08183
Multidrug resistance protein 1 (P08183)
Multidrug resistance protein 1 (UniProt P08183), EC 3.6.3.44, 7.6.2.1: 17 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 134 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P08183
- Protein
- Multidrug resistance protein 1
- EC
- 3.6.3.44, 7.6.2.1, 7.6.2.2
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 134 · 9 records with a druggable one
Structures
18 records of P08183 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6C0V | Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation | electron microscopy | A | ATP, MG | 15 (best 0.88) |
| 6C0V | Molecular structure of human P-glycoprotein in the ATP-bound, outward- facing conformation | electron microscopy | A | ATP, MG | — |
| 6QEX | Nanodisc reconstituted human ABCB1 in complex with UIC2 fab and taxol | electron microscopy | A | NAG, CLR, TA1, 3PE | 15 (best 0.89) |
| 6QEX | Nanodisc reconstituted human ABCB1 in complex with UIC2 Fab and taxol | electron microscopy | A | NAG, CLR, TA1, 3PE | — |
| 7A65 | Nanodisc reconstituted, drug-free human ABCB1 in complex with MRK16 Fab | electron microscopy | A | CLR | 16 (best 0.89) |
| 7A65 | Nanodisc reconstituted, drug-free human ABCB1 in complex with MRK16 Fab | electron microscopy | A | CLR | — |
| 7A69 | Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine | electron microscopy | A | R1Q, CLR | 17 (best 0.84) |
| 7A69 | Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine | electron microscopy | A | R1Q, CLR | — |
| 7A6C | Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and elacridar | electron microscopy | A | R0Z, CLR | 17 (best 0.89) |
| 7A6C | Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and elacridar | electron microscopy | A | R0Z, CLR | — |
| 7A6E | Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar | electron microscopy | A | R1H, CLR | 15 (best 0.89) |
| 7A6E | Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar | electron microscopy | A | R1H, CLR | — |
| 7A6F | Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and zosuquidar | electron microscopy | A | ZQU, CLR | 17 (best 0.88) |
| 7A6F | Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and zosuquidar | electron microscopy | A | ZQU, CLR | — |
| 7O9W | Encequidar-bound human P-glycoprotein in complex with UIC2-Fab | electron microscopy | A | V5Q | 17 (best 0.85) |
| 7O9W | Encequidar-bound human P-glycoprotein in complex with UIC2-Fab | electron microscopy | A | V5Q | — |
| 8Y6H | P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent | electron microscopy | A | R0Z | 5 (best 0.87) |
| P08183 | AlphaFold monomer V2.0 prediction for ATP-dependent translocase ABCB1 (P08183) | predicted | A | — | — |
Ligands
- CLR · Cholesterol · in 12 records
- R0Z · elacridar · in 3 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 2 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- MG · Magnesium ion · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- R1H · tariquidar · in 2 records
- R1Q · vincristine · in 2 records
- TA1 · Taxol · in 2 records
- V5Q · ~{N}-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1~{H}-isoquinolin-2-yl)ethyl]phenyl]-1,2,3,4-tetrazol-5-yl]-4,5-dimethoxy-phenyl]-4-oxidanylidene-2,3-dihydrochromene-2-carboxamide · in 2 records
- ZQU · Zosuquidar · in 2 records
Experiment against prediction
- 8Y6H chain A against the predicted model P08183: TM-score 0.92, RMSD 3.00 Å
- 7O9W chain A against the predicted model P08183: TM-score 0.90, RMSD 3.94 Å
- 7O9W chain A against the predicted model P08183: TM-score 0.90, RMSD 3.94 Å
- 7A6F chain A against the predicted model P08183: TM-score 0.89, RMSD 4.22 Å
- 7A6F chain A against the predicted model P08183: TM-score 0.89, RMSD 4.22 Å
- 6QEX chain A against the predicted model P08183: TM-score 0.89, RMSD 4.28 Å
- 6QEX chain A against the predicted model P08183: TM-score 0.89, RMSD 4.28 Å
- 7A69 chain A against the predicted model P08183: TM-score 0.88, RMSD 4.43 Å
- 7A69 chain A against the predicted model P08183: TM-score 0.88, RMSD 4.43 Å
- 7A65 chain A against the predicted model P08183: TM-score 0.88, RMSD 4.47 Å
Elsewhere
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