MolNFT v1 · #183993 · protein
Encequidar-bound human P-glycoprotein in complex with UIC2-Fab
7O9W: “Encequidar-bound human P-glycoprotein in complex with UIC2-Fab”. Electron microscopy, 1 ligand (V5Q). MolNFT v1 #183993 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7O9W
- Type
- protein
- Length
- 1,614 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P08183
- Ligands
- V5Q
Structure
electron microscopy · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1169 | — | P08183 |
| B | — | protein | 220 | — | — |
| C | — | protein | 225 | — | — |
Ligands and binding sites
- V5Q · ~{N}-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1~{H}-isoquinolin-2-yl)ethyl]phenyl]-1,2,3,4-tetrazol-5-yl]-4,5-dimethoxy-phenyl]-4-oxidanylidene-2,3-dihydrochromene-2-carboxamide · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7O9W · Encequidar-bound human P-glycoprotein in complex with UIC2-Fab · the same entry in another collection · chain A against A, TM-score 1.00
- P08183 · AlphaFold monomer V2.0 prediction for ATP-dependent translocase ABCB1 (P08183) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08183
- Elsewhere: RCSB PDB 7O9W · PDBe 7O9W · UniProt P08183
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