MolNFT v1 · #161450 · protein
Nanodisc reconstituted human ABCB1 in complex with UIC2 Fab and taxol
6QEX: “Nanodisc reconstituted human ABCB1 in complex with UIC2 Fab and taxol”. Electron microscopy, 4 ligands (CLR, 3PE, TA1). MolNFT v1 #161450 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6QEX
- Type
- protein
- Length
- 1,627 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P08183
- Ligands
- CLR, 3PE, TA1, NAG
Structure
electron microscopy · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1182 | — | P08183 |
| B | — | protein | 220 | — | — |
| C | — | protein | 225 | — | — |
Ligands and binding sites
- CLR · Cholesterol · ligand · 16 copies · chains A
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · 2 copies · chains A
- TA1 · Taxol · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6QEX · Nanodisc reconstituted human ABCB1 in complex with UIC2 fab and taxol · the same entry in another collection · chain B against B, TM-score 1.00
- P08183 · AlphaFold monomer V2.0 prediction for ATP-dependent translocase ABCB1 (P08183) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08183
- Elsewhere: RCSB PDB 6QEX · PDBe 6QEX · UniProt P08183
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.