UniProt P08069
Insulin-like growth factor 1 receptor beta chain (P08069)
Insulin-like growth factor 1 receptor beta chain (UniProt P08069), EC 2.7.10.1: 68 experimental structures on GenesisL1, 16 ligands bound, 115 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P08069
- Protein
- Insulin-like growth factor 1 receptor beta chain
- EC
- 2.7.10.1
- Experimental structures
- 68
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 115 · 10 records with a druggable one
Structures
68 records of P08069 in the MolNFT archive: 68 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IGR | Type 1 Insulin-like growth factor receptor (DOMAINS 1-3) | x-ray diffraction | A | — | — |
| 1IGR | Type 1 insulin-like growth factor receptor (domains 1-3) | x-ray diffraction | A | — | — |
| 1JQH | IGF-1 receptor kinase domain | x-ray diffraction | A, B, C | — | — |
| 1JQH | Igf-1 receptor kinase domain | x-ray diffraction | A, B, C | — | — |
| 1K3A | Structure of the Insulin-like Growth Factor 1 Receptor Kinase | x-ray diffraction | A | — | — |
| 1K3A | Structure of the insulin-like growth factor 1 receptor kinase | x-ray diffraction | A | — | — |
| 1M7N | Crystal Structure of Unactivated APO Insulin-like Growth Factor-1 Receptor Kinase Domain | x-ray diffraction | A, B | — | — |
| 1M7N | Crystal structure of unactivated apo insulin-like growth factor-1 receptor kinase domain | x-ray diffraction | A, B | — | — |
| 1P4O | Structure of Apo unactivated IGF-1R KInase domain at 1.5A resolution. | x-ray diffraction | A, B | — | — |
| 1P4O | Structure of apo unactivated igf-1R kinase domain at 1.5A resolution. | x-ray diffraction | A, B | — | — |
| 2OJ9 | Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor | x-ray diffraction | A | — | — |
| 2OJ9 | Structure of igf-1R kinase domain complexed with a benzimidazole inhibitor | x-ray diffraction | A | — | — |
| 2ZM3 | Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 2ZM3 | Complex structure of insulin-like growth factor receptor and isoquinolinedione inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 3D94 | Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP | x-ray diffraction | A | — | — |
| 3D94 | Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with pqip | x-ray diffraction | A | — | — |
| 3F5P | Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, M, L, R, S, T | — | — |
| 3F5P | Complex structure of insulin-like growth factor receptor and 3- cyanoquinoline inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, M, L, R, S, T | — | — |
| 3I81 | Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807… | x-ray diffraction | A | — | — |
| 3I81 | Crystal structure of insulin-like growth factor 1 receptor (igf-1R-wt) complex with bms-754807… | x-ray diffraction | A | — | — |
| 3LVP | Crystal structure of bisphosphorylated IGF1-R Kinase domain (2P) in complex with a bis-azaindole… | x-ray diffraction | A, B, C, D | — | — |
| 3LVP | Crystal structure of bisphosphorylated IGF1-R kinase domain (2P) in complex with a bis-azaindole… | x-ray diffraction | A, B, C, D | — | — |
| 3LW0 | IGF-1RK in complex with ligand MSC1609119A-1 | x-ray diffraction | A, B, C, D | — | — |
| 3LW0 | Igf-1RK in complex with ligand MSC1609119A-1 | x-ray diffraction | A, B, C, D | — | — |
| 3NW5 | Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked… | x-ray diffraction | A | — | — |
| 3NW5 | Crystal structure of insulin-like growth factor 1 receptor (igf-1R-wt) complex with a carbon-linked… | x-ray diffraction | A | — | — |
| 3NW6 | Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked… | x-ray diffraction | A | — | — |
| 3NW6 | Crystal structure of insulin-like growth factor 1 receptor (igf-1R-wt) complex with a carbon-linked… | x-ray diffraction | A | — | — |
| 3NW7 | Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked… | x-ray diffraction | A | — | — |
| 3NW7 | Crystal structure of insulin-like growth factor 1 receptor (igf-1R-wt) complex with a carbon-linked… | x-ray diffraction | A | — | — |
| 3O23 | Human unphosphorylated IGF1-R Kinase domain in complex with an hydantoin inhibitor | x-ray diffraction | A | — | — |
| 3O23 | Human unphosphorylated IGF1-R kinase domain in complex with an hydantoin inhibitor | x-ray diffraction | A | — | — |
| 3QQU | Cocrystal structure of unphosphorylated igf with pyrimidine 8 | x-ray diffraction | A, B, C, D | — | — |
| 3QQU | Cocrystal structure of unphosphorylated igf with pyrimidine 8 | x-ray diffraction | A, B, C, D | — | — |
| 4D2R | Human IGF in complex with a Dyrk1B inhibitor | x-ray diffraction | A | — | — |
| 4D2R | Human igf in complex with a DYRK1B inhibitor | x-ray diffraction | A | — | — |
| 5FXQ | IGFR-1R complex with a pyrimidine inhibitor. | x-ray diffraction | A | GD5 | — |
| 5FXQ | Igfr-1R complex with a pyrimidine inhibitor. | x-ray diffraction | A | — | — |
| 5FXR | IGFR-1R complex with a pyrimidine inhibitor. | x-ray diffraction | A | 8LN | — |
| 5FXR | Igfr-1R complex with a pyrimidine inhibitor. | x-ray diffraction | A | — | — |
| 5FXS | IGFR-1R complex with a pyrimidine inhibitor. | x-ray diffraction | A | OZN | — |
| 5FXS | Igfr-1R complex with a pyrimidine inhibitor. | x-ray diffraction | A | — | — |
| 5HZN | Structure of NVP-AEW541 in complex with IGF-1R kinase | x-ray diffraction | A, B, C, D, E, F, G, H | 66A, SO4 | — |
| 5HZN | Structure of nvp-AEW541 in complex with igf-1R kinase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5U8Q | Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with… | x-ray diffraction | A | NAG, SO4, MLT | 8 (best 0.69) |
| 5U8Q | Structure of the ectodomain of the human type 1 insulin-like growth factor receptor in complex with… | x-ray diffraction | A | NAG, SO4, MLT | — |
| 5U8R | Structure of the ectodomain of the human type 1 insulin-like growth factor receptor | x-ray diffraction | A | NAG, SO4, MLT | — |
| 6JK8 | Cryo-EM structure of the full-length human igf-1R in complex with insulin | electron microscopy | A, B | NAG, MAN | — |
| 6VWG | Head region of the open conformation of the human type 1 insulin-like growth factor receptor… | electron microscopy | A, B | NAG | — |
| 6VWH | Leg region of the open conformation of the human type 1 insulin-like growth factor receptor… | electron microscopy | A, B | — | — |
| 6VWI | Head region of the closed conformation of the human type 1 insulin-like growth factor receptor… | electron microscopy | A, B | NAG | 7 (best 0.78) |
| 6VWI | Head region of the closed conformation of the human type 1 insulin- like growth factor receptor… | electron microscopy | A, B | NAG | — |
| 6VWJ | Leg region of the closed conformation of the human type 1 insulin-like growth factor receptor… | electron microscopy | A, B | — | — |
| 7PH8 | Structure of Insulin-like growth factor 1 receptor's transmembrane domain | solution nmr | A | — | — |
| 7PH8 | Structure of insulin-like growth factor 1 RECEPTOR'S transmembrane domain | solution nmr | A | — | — |
| 7S0Q | Head region of a complex of igf-I with the ectodomain of a hybrid insulin receptor / type 1… | electron microscopy | A | NAG | — |
| 7S8V | Leg region of a complex of igf-I with the ectodomain of a hybrid insulin receptor / type 1… | electron microscopy | A | NAG | — |
| 7U23 | Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form | electron microscopy | E, F | — | 15 (best 0.75) |
| 7V3P | Cryo-EM structure of the IGF1R/insulin complex | electron microscopy | A, B | NAG | 20 (best 0.78) |
| 7V3P | Cryo-EM structure of the IGF1R/INSULIN complex | electron microscopy | A, B | NAG | — |
8 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 13 records
- SO4 · Sulfate ion · in 4 records
- MLT · D-malate · in 3 records
- NI · Nickel (II) ion · in 3 records
- CD · Cadmium ion · in 2 records
- 66A · 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine · in 1 record
- 8LN · 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine · in 1 record
- BMA · beta-D-mannopyranose · in 1 record
- GD5 · 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(5-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine · in 1 record
- IC2 · 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione · in 1 record
- IE0 · (5S)-5-methyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione · in 1 record
- IEA · 5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione · in 1 record
- IER · 3-[8-azanyl-1-(4-ethoxy-8-fluoranyl-2-phenyl-quinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutan-1-ol · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
- OZN · 2-[4-[4-[[(6Z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1H-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-N,N-dimethyl-ethanamide · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 6VWJ chain B against the predicted model P03069: TM-score 0.13, RMSD 6.54 Å
- 6VWH chain B against the predicted model P03069: TM-score 0.14, RMSD 6.28 Å
- 6VWI chain A against the predicted model P03069: TM-score 0.13, RMSD 6.02 Å
- 6VWI chain A against the predicted model P03069: TM-score 0.13, RMSD 6.02 Å
- 6VWG chain B against the predicted model P03069: TM-score 0.17, RMSD 5.29 Å
- 6VWI chain B against the predicted model P03069: TM-score 0.17, RMSD 5.46 Å
- 6VWI chain B against the predicted model P03069: TM-score 0.17, RMSD 5.46 Å
- 6VWG chain A against the predicted model P03069: TM-score 0.12, RMSD 6.12 Å
- 6VWJ chain A against the predicted model P03069: TM-score 0.17, RMSD 5.42 Å
- 6VWH chain A against the predicted model P03069: TM-score 0.16, RMSD 5.21 Å
Elsewhere
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