GL1X · GenesisL1 explorer

Ligand · LGX

LGX · N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{(2R)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amine

LGX, N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{(2R)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amine (C22 H21 F N8 O, 432.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
LGX
Formula
C22 H21 F N8 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

LGX in 2 structures; the first of them:

  • 3NW5 · Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a… · LGX A1 · binds LEU975, GLY976, GLN977, GLY978, VAL983, ALA1001, LYS1003, VAL1033 and 13 more
  • 3NW5 · Crystal structure of insulin-like growth factor 1 receptor (igf-1R-wt) complex with a… · LGX A1 · binds LEU975, GLY976, GLN977, GLY978, VAL983, ALA1001, LYS1003, VAL1033 and 13 more

Residues it binds most

GLY 2, MET 2, ASP 2, LEU 2, VAL 2, ALA 2, ARG 2, GLN 2, GLU 2, ILE 2 (residue and the binding sites it lines).

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