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Ligand · LGV

LGV · N-({4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}methyl)-6-fluoropyridine-3-carboxamide

LGV, N-({4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}methyl)-6-fluoropyridine-3-carboxamide (C19 H17 F N8 O, 392.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
LGV
Formula
C19 H17 F N8 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

LGV in 2 structures; the first of them:

  • 3NW7 · Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a… · LGV A1 · binds LEU975, GLY976, GLN977, VAL983, ALA1001, LYS1003, VAL1033, MET1049 and 14 more
  • 3NW7 · Crystal structure of insulin-like growth factor 1 receptor (igf-1R-wt) complex with a… · LGV A1 · binds LEU975, GLY976, GLN977, VAL983, ALA1001, LYS1003, VAL1033, MET1049 and 14 more

Residues it binds most

MET 2, GLY 2, ASP 2, LEU 2, THR 2, VAL 2, ALA 2, ARG 2, ASN 2, CYS 2 (residue and the binding sites it lines).

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