UniProt P07813
Leucine--tRNA ligase (P07813)
Leucine--tRNA ligase (UniProt P07813): 31 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07813
- Protein
- Leucine--tRNA ligase
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 6 · 1 record with a druggable one
Structures
32 records of P07813 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AJG | Crystal structure of the editing domain of E. coli leucyl-tRNA synthetase | x-ray diffraction | A, B | — | — |
| 2AJG | Crystal structure of the editing domain of E. COLI leucyl-tRNA synthetase | x-ray diffraction | A, B | — | — |
| 2AJH | Crystal structure of the editing domain of E. coli leucyl-tRNA synthetase complexes with methionine | x-ray diffraction | A, B | — | — |
| 2AJH | Crystal structure of the editing domain of E. COLI leucyl-tRNA synthetase complexes with methionine | x-ray diffraction | A, B | — | — |
| 2AJI | Crystal structure of the editing domain of E. coli leucyl-tRNA synthetase complexes with isoleucine | x-ray diffraction | A, B | — | — |
| 2AJI | Crystal structure of the editing domain of E. COLI leucyl-tRNA synthetase complexes with isoleucine | x-ray diffraction | A, B | — | — |
| 3ZGZ | Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and toxic moiety from agrocin 84… | x-ray diffraction | A, D | — | — |
| 3ZGZ | Ternary complex of E. COLI leucyl-tRNA synthetase, TRNA(LEU) and toxic moiety from agrocin 84… | x-ray diffraction | A, D | — | — |
| 3ZJT | Ternary complex of E.coli leucyl-tRNA synthetase, tRNA(Leu)574 and the benzoxaborole AN3017 in the… | x-ray diffraction | A | — | — |
| 3ZJT | Ternary complex of E .COLI leucyl-tRNA synthetase, TRNA(LEU) 574 the benzoxaborole AN3017 in the… | x-ray diffraction | A | — | — |
| 3ZJU | Ternary complex of E .coli leucyl-tRNA synthetase, tRNA(Leu) and the benzoxaborole AN3016 in the… | x-ray diffraction | A | — | — |
| 3ZJU | Ternary complex of E .COLI leucyl-tRNA synthetase, TRNA(LEU) and the benzoxaborole AN3016 in the… | x-ray diffraction | A | — | — |
| 3ZJV | Ternary complex of E .coli leucyl-tRNA synthetase, tRNA(Leu) and the benzoxaborole AN3213 in the… | x-ray diffraction | A | — | — |
| 3ZJV | Ternary complex of E .COLI leucyl-tRNA synthetase, TRNA(LEU) and the benzoxaborole AN3213 in the… | x-ray diffraction | A | — | — |
| 4AQ7 | Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucyl-adenylate analogue in the… | x-ray diffraction | A, D | — | — |
| 4AQ7 | Ternary complex of E. COLI leucyl-tRNA synthetase, TRNA(LEU) and leucyl-adenylate analogue in the… | x-ray diffraction | A, D | — | — |
| 4ARC | Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucine in the editing conformation | x-ray diffraction | A | — | — |
| 4ARC | Ternary complex of E. COLI leucyl-tRNA synthetase, TRNA(LEU) and leucine in the editing conformation | x-ray diffraction | A | — | — |
| 4ARI | Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the… | x-ray diffraction | A | — | — |
| 4ARI | Ternary complex of E. COLI leucyl-tRNA synthetase, TRNA(LEU) and the benzoxaborole AN2679 in the… | x-ray diffraction | A | — | — |
| 4AS1 | Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the… | x-ray diffraction | A | — | — |
| 4AS1 | Ternary complex of E. COLI leucyl-tRNA synthetase, TRNA(LEU) and the benzoxaborole AN2679 in the… | x-ray diffraction | A | — | — |
| 4CQN | Crystal structure of the E.coli LeuRS-tRNA complex with the non- cognate isoleucyl adenylate… | x-ray diffraction | A, D | — | — |
| 4CQN | Crystal structure of the E.COLI leurs-tRNA complex with the non-cognate isoleucyl adenylate analogue | x-ray diffraction | A, D | — | — |
| 5OMW | Mutant T252A of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucyl-adenylate analogue in the… | x-ray diffraction | A, D | ZN, LSS | — |
| 5OMW | Mutant T252A of E. COLI leucyl-tRNA synthetase, TRNA(LEU) and leucyl- adenylate analogue in the… | x-ray diffraction | A, D | ZN, LSS | — |
| 5ON2 | Quaternary complex of mutant T252A of E. coli leucyl-tRNA synthetase with tRNA(leu)… | x-ray diffraction | A, D | ZN, LSS | — |
| 5ON2 | Quaternary complex of mutant T252A of E. COLI leucyl-tRNA synthetase with TRNA(LEU)… | x-ray diffraction | A, D | ZN, LSS | — |
| 5ON3 | Quaternary complex of mutant T252A of E. coli leucyl-tRNA synthetase with tRNA(leu)… | x-ray diffraction | A, D | ZN, LSS | — |
| 5ON3 | Quaternary complex of mutant T252A of E. COLI leucyl-tRNA synthetase with TRNA(LEU)… | x-ray diffraction | A, D | ZN, LSS | — |
| 5ONH | Quaternary complex of wild type E. COLI leucyl-tRNA synthetase with TRNA(LEU), leucyl-adenylate… | x-ray diffraction | A, D | ZN, LSS | — |
| P07813 | AlphaFold monomer V2.0 prediction for leucine--tRNA ligase (P07813) | predicted | A | — | 6 (best 0.74) |
Ligands
Experiment against prediction
- 2AJG chain B against the predicted model P07813: TM-score 0.98, RMSD 0.81 Å
- 2AJG chain B against the predicted model P07813: TM-score 0.98, RMSD 0.81 Å
- 2AJH chain B against the predicted model P07813: TM-score 0.98, RMSD 0.70 Å
- 2AJH chain B against the predicted model P07813: TM-score 0.98, RMSD 0.70 Å
- 2AJI chain B against the predicted model P07813: TM-score 0.98, RMSD 0.72 Å
- 2AJI chain B against the predicted model P07813: TM-score 0.98, RMSD 0.72 Å
- 2AJG chain A against the predicted model P07813: TM-score 0.97, RMSD 0.88 Å
- 2AJG chain A against the predicted model P07813: TM-score 0.97, RMSD 0.88 Å
- 2AJI chain A against the predicted model P07813: TM-score 0.97, RMSD 0.83 Å
- 2AJI chain A against the predicted model P07813: TM-score 0.97, RMSD 0.83 Å
Elsewhere
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