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Ligand · VRT

VRT · 2'-(L-norvalyl)amino-2'-deoxyadenosine

VRT, 2'-(L-norvalyl)amino-2'-deoxyadenosine (C15 H23 N7 O4, 365.4 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
VRT
Formula
C15 H23 N7 O4
Class
ligand
Structures
8
PDB entries
4

Binding sites

VRT in 8 structures; the first of them:

  • 5FOG · Crystal structure of hte Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing… · VRT A1542 · binds TYR258, ALA286, THR287, LEU288, ARG289, THR292, MET293, ILE414 and 10 more
  • 5ON2 · Quaternary complex of mutant T252A of E. coli leucyl-tRNA synthetase with tRNA(leu)… · VRT A902 · binds TYR246, THR247, THR248, ARG249, ALA252, PHE325, VAL326, LEU327 and 11 more
  • 5ONH · Quaternary complex of wild type E. coli leucyl-tRNA synthetase with tRNA(leu)… · VRT A902 · binds TYR246, THR247, THR248, ARG249, THR252, PHE325, VAL326, LEU327 and 11 more
  • 6LPF · The crystal structure of human cytoplasmic LRS · VRT B1103 · binds TYR264, ALA292, THR293, LEU294, ARG295, THR298, MET299, ILE380 and 12 more
  • 5FOG · Crystal structure of hte cryptosporidium muris cytosolic leucyl-tRNA synthetase editing… · VRT A1542 · binds TYR258, ALA286, THR287, LEU288, ARG289, THR292, MET293, ILE414 and 10 more
  • 5ON2 · Quaternary complex of mutant T252A of E. COLI leucyl-tRNA synthetase with TRNA(LEU)… · VRT A902 · binds TYR246, THR247, THR248, ARG249, ALA252, PHE325, VAL326, LEU327 and 11 more
  • 5ONH · Quaternary complex of wild type E. COLI leucyl-tRNA synthetase with TRNA(LEU)… · VRT A902 · binds TYR246, THR247, THR248, ARG249, THR252, PHE325, VAL326, LEU327 and 11 more
  • 6LPF · The crystal structure of human cytoplasmic lrs · VRT B1103 · binds TYR264, ALA292, THR293, LEU294, ARG295, THR298, MET299, ILE380 and 12 more

Residues it binds most

THR 18, VAL 18, GLY 18, ALA 18, ASP 18, ARG 18, SER 12, TYR 18, LYS 10, LEU 18 (residue and the binding sites it lines).

Found with

  • LSS · 5'-O-(L-leucylsulfamoyl)adenosine
  • MG · Magnesium ion
  • ZN · Zinc ion
  • K · Potassium ion
  • EDO · 1,2-ethanediol
  • GOL · Glycerol

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