UniProt P06280
Alpha-galactosidase A (P06280)
Alpha-galactosidase A (UniProt P06280), EC 3.2.1.22: 46 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P06280
- Protein
- Alpha-galactosidase A
- EC
- 3.2.1.22
- Experimental structures
- 46
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 16 · 8 records with a druggable one
Structures
47 records of P06280 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1R46 | Structure of human alpha-galactosidase | x-ray diffraction | A, B | — | — |
| 1R46 | Structure of human alpha-galactosidase | x-ray diffraction | A, B | — | — |
| 1R47 | Structure of human alpha-galactosidase | x-ray diffraction | A, B | — | — |
| 1R47 | Structure of human alpha-galactosidase | x-ray diffraction | A, B | — | — |
| 3GXN | Crystal structure of apo alpha-galactosidase A at pH 4.5 | x-ray diffraction | A, B | — | — |
| 3GXN | Crystal structure of apo alpha-galactosidase a at pH 4.5 | x-ray diffraction | A, B | — | — |
| 3GXP | Crystal structure of acid-alpha-galactosidase A complexed with galactose at pH 4.5 | x-ray diffraction | A, B | — | — |
| 3GXP | Crystal structure of acid-alpha-galactosidase a complexed with galactose at pH 4.5 | x-ray diffraction | A, B | — | — |
| 3GXT | Crystal structure of alpha-galactosidase A at pH 4.5 complexed with 1-deoxygalactonijirimycin | x-ray diffraction | A, B | — | — |
| 3GXT | Crystal structure of alpha-galactosidase a at pH 4.5 complexed with 1- deoxygalactonijirimycin | x-ray diffraction | A, B | — | — |
| 3HG2 | Human alpha-galactosidase catalytic mechanism 1. Empty active site | x-ray diffraction | A, B | — | — |
| 3HG2 | Human alpha-galactosidase catalytic mechanism 1. empty active site | x-ray diffraction | A, B | — | — |
| 3HG3 | Human alpha-galactosidase catalytic mechanism 2. Substrate bound | x-ray diffraction | A, B | — | — |
| 3HG3 | Human alpha-galactosidase catalytic mechanism 2. substrate bound | x-ray diffraction | A, B | — | — |
| 3HG4 | Human alpha-galactosidase catalytic mechanism 3. Covalent intermediate | x-ray diffraction | A, B | — | — |
| 3HG4 | Human alpha-galactosidase catalytic mechanism 3. covalent intermediate | x-ray diffraction | A, B | — | — |
| 3HG5 | Human alpha-galactosidase catalytic mechanism 4. Product bound | x-ray diffraction | A, B | — | — |
| 3HG5 | Human alpha-galactosidase catalytic mechanism 4. product bound | x-ray diffraction | A, B | — | — |
| 3LX9 | Interconversion of Human Lysosomal Enzyme Specificities | x-ray diffraction | A, B | — | — |
| 3LX9 | Interconversion of human lysosomal enzyme specificities | x-ray diffraction | A, B | — | — |
| 3LXA | Interconversion of Human Lysosomal Enzyme Specificities | x-ray diffraction | A, B | — | — |
| 3LXA | Interconversion of human lysosomal enzyme specificities | x-ray diffraction | A, B | — | — |
| 3LXB | Interconversion of Human Lysosomal Enzyme Specificities | x-ray diffraction | A, B | — | — |
| 3LXB | Interconversion of human lysosomal enzyme specificities | x-ray diffraction | A, B | — | — |
| 3LXC | Interconversion of Human Lysosomal Enzyme Specificities | x-ray diffraction | A, B | — | — |
| 3LXC | Interconversion of human lysosomal enzyme specificities | x-ray diffraction | A, B | — | — |
| 3S5Y | Pharmacological Chaperoning in Human alpha-Galactosidase | x-ray diffraction | A, B | — | — |
| 3S5Y | Pharmacological chaperoning in human alpha-galactosidase | x-ray diffraction | A, B | — | — |
| 3S5Z | Pharmacological Chaperoning in Human alpha-Galactosidase | x-ray diffraction | A, B | — | — |
| 3S5Z | Pharmacological chaperoning in human alpha-galactosidase | x-ray diffraction | A, B | — | — |
| 3TV8 | Pharmacological Chaperoning in Human alpha-Galactosidase | x-ray diffraction | A, B | — | — |
| 3TV8 | Pharmacological chaperoning in human alpha-galactosidase | x-ray diffraction | A, B | — | — |
| 4NXS | Crystal structure of human alpha-galactosidase A in complex with 1-deoxygalactonojirimycin-pFPhT | x-ray diffraction | A, B | — | — |
| 4NXS | Crystal structure of human alpha-galactosidase a in complex with 1- deoxygalactonojirimycin-pfpht | x-ray diffraction | A, B | — | — |
| 6IBK | Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured… | x-ray diffraction | A, B | NAG, MAN, SO4, YTW | 1 (best 0.62) |
| 6IBK | Crystal structure of human alpha-galactosidase a in complex with alpha-galactose configured… | x-ray diffraction | A, B | NAG, MAN, SO4, YTW | — |
| 6IBM | Crystal structure of human alpha-galactosidase a in complex with alpha-galactose configured… | x-ray diffraction | A, B | NAG, MAN, SO4, HF8 | — |
| 6IBR | Crystal structure of human alpha-galactosidase a in complex with alpha-galactose configured… | x-ray diffraction | A, B | NAG, SO4, HBE | — |
| 6IBT | Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured… | x-ray diffraction | A, B | NAG, MAN, H9T, SO4 | 2 (best 0.63) |
| 6IBT | Crystal structure of human alpha-galactosidase a in complex with alpha-galactose configured… | x-ray diffraction | A, B | NAG, H9T, SO4 | — |
| 8K7D | Crystal structure of human lysosomal alpha-galactosidase A in complex with… | x-ray diffraction | A, B | NAG, MAN, VLN, SO4 | 3 (best 0.59) |
| 8K7G | Crystal structure of human lysosomal alpha-galactosidase A in complex with… | x-ray diffraction | A, B | NAG, MAN, VMF, SO4 | 2 (best 0.64) |
| 8K7H | Crystal structure of human lysosomal alpha-galactosidase A in complex with… | x-ray diffraction | A, B | NAG, MAN, VMO, SO4 | 2 (best 0.64) |
| 8K7I | Crystal structure of human lysosomal alpha-galactosidase A in complex with… | x-ray diffraction | A, B | NAG, MAN, VN0, SO4 | 2 (best 0.67) |
| 8K7K | Crystal structure of human lysosomal alpha-galactosidase A in complex with… | x-ray diffraction | A, B | NAG, MAN, VNQ, SO4 | 2 (best 0.62) |
| 8K7L | Crystal structure of human lysosomal alpha-galactosidase A in complex with… | x-ray diffraction | A, B | NAG, MAN, VO0, SO4 | 2 (best 0.64) |
| P06280 | AlphaFold monomer V2.0 prediction for alpha-galactosidase a (P06280) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 12 records
- SO4 · Sulfate ion · in 12 records
- MAN · alpha-D-mannopyranose · in 10 records
- H9T · (1~{S},2~{S},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol · in 2 records
- YTW · (3~{A}~{R},4~{S},5~{S},6~{S},7~{R},7~{A}~{S})-7-(hydroxymethyl)-2,2-bis(oxidanylidene)-3~{A},4,5,6,7, 7~{A}-hexahydro-3~{H}-benzo[d][1,2,3]oxathiazole-4,5, 6-triol · in 2 records
- HBE · (2~{R},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-oxabicyclo[4.1.0]heptane-2,3,4-triol · in 1 record
- HF8 · [(1~{S},2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-3,4,5,6-tetrakis(oxidanyl)cyclohexyl] hydrogen sulfate · in 1 record
- VLN · (2~{R},3~{R},4~{S},5~{R})-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol · in 1 record
- VMF · (2~{R},3~{R},4~{S},5~{R})-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol · in 1 record
- VMO · (2~{R},3~{S},4~{R})-2-(hydroxymethyl)-1-methyl-pyrrolidine-3,4-diol · in 1 record
- VN0 · (2~{R},3~{S},4~{R},5~{R})-2-(hydroxymethyl)-5-(methylaminomethyl)pyrrolidine-3,4-diol · in 1 record
- VNQ · (2~{R},3~{S},4~{R},5~{R})-2,5-bis(hydroxymethyl)-1-methyl-pyrrolidine-3,4-diol · in 1 record
- VO0 · (2~{R},3~{R},4~{S},5~{R})-2-(aminomethyl)-5-(hydroxymethyl)-1-methyl-pyrrolidine-3,4-diol · in 1 record
Experiment against prediction
- 8K7K chain A against the predicted model P06280: TM-score 1.00, RMSD 0.31 Å
- 3HG2 chain A against the predicted model P06280: TM-score 1.00, RMSD 0.31 Å
- 3HG2 chain A against the predicted model P06280: TM-score 1.00, RMSD 0.31 Å
- 8K7H chain A against the predicted model P06280: TM-score 1.00, RMSD 0.31 Å
- 3LXC chain B against the predicted model P06280: TM-score 1.00, RMSD 0.31 Å
- 3LXC chain B against the predicted model P06280: TM-score 1.00, RMSD 0.31 Å
- 6IBM chain A against the predicted model P06280: TM-score 1.00, RMSD 0.31 Å
- 8K7L chain A against the predicted model P06280: TM-score 1.00, RMSD 0.32 Å
- 3TV8 chain A against the predicted model P06280: TM-score 1.00, RMSD 0.32 Å
- 3TV8 chain A against the predicted model P06280: TM-score 1.00, RMSD 0.32 Å
Elsewhere
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