UniProt P06239
Tyrosine-protein kinase Lck (P06239)
Tyrosine-protein kinase Lck (UniProt P06239), EC 2.7.10.2: 109 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P06239
- Protein
- Tyrosine-protein kinase Lck
- EC
- 2.7.10.2
- Experimental structures
- 109
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 4 · 1 record with a druggable one
Structures
110 records of P06239 in the MolNFT archive: 109 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BHF | P56LCK SH2 domain inhibitor complex | x-ray diffraction | A | — | — |
| 1BHF | P56LCK SH2 domain inhibitor complex | x-ray diffraction | A | — | — |
| 1BHH | Free P56LCK SH2 domain | x-ray diffraction | A, B | — | — |
| 1BHH | Free P56LCK SH2 domain | x-ray diffraction | A, B | — | — |
| 1CWD | Human P56LCK tyrosine kinase complexed with phosphopeptide | x-ray diffraction | L | — | — |
| 1CWD | Human P56LCK tyrosine kinase complexed with phosphopeptide | x-ray diffraction | L | — | — |
| 1CWE | Human P56LCK tyrosine kinase complexed with phosphopeptide | x-ray diffraction | A, C | — | — |
| 1CWE | Human P56LCK tyrosine kinase complexed with phosphopeptide | x-ray diffraction | A, C | — | — |
| 1FBZ | Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo… | x-ray diffraction | A, B | — | — |
| 1FBZ | Structure-based design of a novel, osteoclast-selective, nonpeptide src SH2 inhibitor with in vivo… | x-ray diffraction | A, B | — | — |
| 1H92 | SH3 domain of human Lck tyrosine kinase | solution nmr | A | — | — |
| 1H92 | SH3 domain of human lck tyrosine kinase | solution nmr | A | — | — |
| 1IJR | Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic | x-ray diffraction | A | — | — |
| 1IJR | Crystal structure of lck SH2 complexed with nonpeptide phosphotyrosine mimetic | x-ray diffraction | A | — | — |
| 1KIK | SH3 Domain of Lymphocyte Specific Kinase (LCK) | solution nmr | A | — | — |
| 1KIK | SH3 domain of lymphocyte specific kinase (lck) | solution nmr | A | — | — |
| 1LCJ | SH2 (src homology-2) domain of human P56-lck tyrosine kinase complexed with the 11 residue… | x-ray diffraction | A | — | — |
| 1LCJ | SH2 (src homology-2) domain of human P56-lck tyrosine kinase complexed with the 11 residue… | x-ray diffraction | A | — | — |
| 1LCK | SH3-SH2 domain fragment of human P56-lck tyrosine kinase complexed with the 10 residue synthetic… | x-ray diffraction | A, B | — | — |
| 1LCK | SH3-SH2 domain fragment of human P56-lck tyrosine kinase complexed with the 10 residue synthetic… | x-ray diffraction | A, B | — | — |
| 1LKK | Human P56-lck tyrosine kinase SH2 domain in complex with the phosphotyrosyl peptide… | x-ray diffraction | A | — | — |
| 1LKK | Human P56-lck tyrosine kinase SH2 domain in complex with the phosphotyrosyl peptide… | x-ray diffraction | A | — | — |
| 1LKL | Human P56-lck tyrosine kinase SH2 domain in complex with the phosphotyrosyl peptide… | x-ray diffraction | A | — | — |
| 1LKL | Human P56-lck tyrosine kinase SH2 domain in complex with the phosphotyrosyl peptide… | x-ray diffraction | A | — | — |
| 1Q68 | Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase… | solution nmr | B | — | — |
| 1Q68 | Solution structure of T-cell surface glycoprotein CD4 and proto- oncogene tyrosine-protein kinase… | solution nmr | B | — | — |
| 1Q69 | Solution structure of T-cell surface glycoprotein CD8 alpha chain and Proto-oncogene… | solution nmr | B | — | — |
| 1Q69 | Solution structure of T-cell surface glycoprotein CD8 alpha chain and proto-oncogene… | solution nmr | B | — | — |
| 1QPC | Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective and src… | x-ray diffraction | A | — | — |
| 1QPC | Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective and src… | x-ray diffraction | A | — | — |
| 1QPD | Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective and src… | x-ray diffraction | A | — | — |
| 1QPD | Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective and src… | x-ray diffraction | A | — | — |
| 1QPE | Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective and src… | x-ray diffraction | A | — | — |
| 1QPE | Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective and src… | x-ray diffraction | A | — | — |
| 1QPJ | Crystal structure of the lymphocyte-specific kinase lck in complex with staurosporine. | x-ray diffraction | A | — | — |
| 1QPJ | Crystal structure of the lymphocyte-specific kinase lck in complex with staurosporine. | x-ray diffraction | A | — | — |
| 1X27 | Crystal Structure of Lck SH2-SH3 with SH2 binding site of p130Cas | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1X27 | Crystal structure of lck SH2-SH3 with SH2 binding site of P130CAS | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2IIM | SH3 Domain of Human Lck | x-ray diffraction | A | — | — |
| 2IIM | SH3 domain of human lck | x-ray diffraction | A | — | — |
| 2OF2 | crystal structure of furanopyrimidine 8 bound to lck | x-ray diffraction | A | — | — |
| 2OF2 | Crystal structure of furanopyrimidine 8 bound to lck | x-ray diffraction | A | — | — |
| 2OF4 | crystal structure of furanopyrimidine 1 bound to lck | x-ray diffraction | A | — | — |
| 2OF4 | Crystal structure of furanopyrimidine 1 bound to lck | x-ray diffraction | A | — | — |
| 2OFU | x-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to Lck | x-ray diffraction | A | — | — |
| 2OFU | X-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to lck | x-ray diffraction | A | — | — |
| 2OFV | crystal structure of aminoquinazoline 1 bound to Lck | x-ray diffraction | A, B | — | — |
| 2OFV | Crystal structure of aminoquinazoline 1 bound to lck | x-ray diffraction | A, B | — | — |
| 2OG8 | crystal structure of aminoquinazoline 36 bound to Lck | x-ray diffraction | A, B | — | — |
| 2OG8 | Crystal structure of aminoquinazoline 36 bound to lck | x-ray diffraction | A, B | — | — |
| 2PL0 | LCK bound to imatinib | x-ray diffraction | A | — | — |
| 2PL0 | Lck bound to imatinib | x-ray diffraction | A | — | — |
| 2ZM1 | Crystal structure of imidazo pyrazin 1 bound to the kinase domain of human LCK… | x-ray diffraction | A | — | — |
| 2ZM1 | Crystal structure of imidazo pyrazin 1 bound to the kinase domain of human lck… | x-ray diffraction | A | — | — |
| 2ZM4 | Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human LCK, activated form… | x-ray diffraction | A | — | — |
| 2ZM4 | Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human lck, activated form… | x-ray diffraction | A | — | — |
| 2ZYB | Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK… | x-ray diffraction | A | — | — |
| 2ZYB | Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human lck… | x-ray diffraction | A | — | — |
| 3AC1 | Crystal structure of pyrazin derivative bound to the kinase domain of Human LCK… | x-ray diffraction | A | — | — |
| 3AC1 | Crystal structure of pyrazin derivative bound to the kinase domain of human lck… | x-ray diffraction | A | — | — |
50 records more on the page itself.
Ligands
Experiment against prediction
- 1IJR chain A against the predicted model P06239: TM-score 0.97, RMSD 0.95 Å
- 1IJR chain A against the predicted model P06239: TM-score 0.97, RMSD 0.95 Å
- 1BHF chain A against the predicted model P06239: TM-score 0.97, RMSD 0.82 Å
- 1BHF chain A against the predicted model P06239: TM-score 0.97, RMSD 0.82 Å
- 1LKL chain A against the predicted model P06239: TM-score 0.97, RMSD 0.81 Å
- 1LKL chain A against the predicted model P06239: TM-score 0.97, RMSD 0.81 Å
- 1LKK chain A against the predicted model P06239: TM-score 0.97, RMSD 0.83 Å
- 1LKK chain A against the predicted model P06239: TM-score 0.97, RMSD 0.83 Å
- 8X2P chain A against the predicted model P06239: TM-score 0.96, RMSD 0.95 Å
- 1LCJ chain A against the predicted model P06239: TM-score 0.96, RMSD 1.05 Å
Elsewhere
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