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Ligand · AM5

AM5 · 4-methyl-N~3~-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)-N~1~-[3-(trifluoromethyl)phenyl]benzene-1,3-dicarboxamide

AM5, 4-methyl-N~3~-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)-N~1~-[3-(trifluoromethyl)phenyl]benzene-1,3-dicarboxamide (C31 H30 F3 N7 O2, 589.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
AM5
Formula
C31 H30 F3 N7 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

AM5 in 2 structures; the first of them:

  • 3BYS · co-crystal structure of Lck and aminopyrimidine amide 10b · AM5 A1 · binds LEU251, VAL259, ALA271, VAL272, LYS273, GLU288, LEU291, MET292 and 19 more
  • 3BYS · Co-crystal structure of lck and aminopyrimidine amide 10B · AM5 A1 · binds LEU251, VAL259, ALA271, VAL272, LYS273, GLU288, LEU291, MET292 and 19 more

Residues it binds most

LEU 2, GLU 2, ILE 2, VAL 2, ALA 2, MET 2, TYR 2, ASP 2, GLY 2, HIS 2 (residue and the binding sites it lines).

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