Ligand · PP2
PP2 · 1-tert-butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
PP2, 1-tert-butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine (C15 H17 Cl N5 +1, 302.8 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the…
- Component
- PP2
- Formula
- C15 H17 Cl N5 +1
- Class
- ligand
- Structures
- 10
- PDB entries
- 5
Binding sites
PP2 in 10 structures; the first of them:
- 1QPE · Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective… · PP2 A1904 · binds LEU251, VAL259, ALA271, LYS273, GLU288, MET292, VAL301, ILE314 and 8 more
- 2ZV9 · Lyn Tyrosine Kinase Domain-PP2 complex · PP2 A513 · binds LEU253, VAL261, ALA273, LYS275, GLU290, MET294, VAL303, ILE317 and 9 more
- 3GEQ · Structural basis for the chemical rescue of Src kinase activity · PP2 A1 · binds LEU273, GLY274, VAL281, ALA293, LYS295, GLU310, MET314, VAL323 and 10 more
- 3SXS · Crystal structure of BMX non-receptor tyrosine kinase complexed with PP2 · PP2 A1 · binds LEU423, GLY424, SER425, GLN427, VAL431, ALA443, LYS445, MET464 and 11 more
- 4FEW · Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate… · PP2 A302 · binds ILE40, PHE53, LYS55, GLU68, PRO82, THR98, THR99, ALA100 and 8 more
- 1QPE · Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective… · PP2 A1904 · binds LEU251, VAL259, ALA271, LYS273, GLU288, MET292, VAL301, ILE314 and 8 more
- 2ZV9 · Lyn tyrosine kinase domain-PP2 complex · PP2 A513 · binds LEU253, VAL261, ALA273, LYS275, GLU290, MET294, VAL303, ILE317 and 9 more
- 3GEQ · Structural basis for the chemical rescue of src kinase activity · PP2 A1 · binds LEU273, GLY274, VAL281, ALA293, LYS295, GLU310, MET314, VAL323 and 10 more
- 3SXS · Crystal structure of bmx non-receptor tyrosine kinase complexed with PP2 · PP2 A1 · binds LEU423, GLY424, SER425, GLN427, VAL431, ALA443, LYS445, MET464 and 11 more
- 4FEW · Crystal structure of the aminoglycoside phosphotransferase APH(3')-ia, with substrate… · PP2 A302 · binds ILE40, PHE53, LYS55, GLU68, PRO82, THR98, THR99, ALA100 and 8 more
Residues it binds most
ILE 22, THR 22, ALA 22, GLY 22, GLU 16, LYS 22, ASP 20, VAL 12, GLN 14, LEU 10 (residue and the binding sites it lines).
Found with
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