UniProt P05106
Integrin beta-3 (P05106)
Integrin beta-3 (UniProt P05106): 178 experimental structures and 1 predicted model on GenesisL1, 25 ligands bound, 162 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P05106
- Protein
- Integrin beta-3
- Experimental structures
- 178
- Predicted models
- 1
- Ligands
- 25
- Pockets
- 162 · 17 records with a druggable one
Structures
179 records of P05106 in the MolNFT archive: 178 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KUP | Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins | solution nmr | B | — | — |
| 1KUP | Solution structure of the membrane proximal regions of alpha-iib and beta-3 integrins | solution nmr | B | — | — |
| 1KUZ | Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins | solution nmr | B | — | — |
| 1KUZ | Solution structure of the membrane proximal regions of alpha-iib and beta-3 integrins | solution nmr | B | — | — |
| 1L5G | Crystal structure of the extracellular segment of integrin AVB3 in complex with an arg-gly-asp… | x-ray diffraction | B | — | — |
| 1L5G | Crystal structure of the extracellular segment of integrin AVB3 in complex with an arg-gly-asp… | x-ray diffraction | B | — | — |
| 1M1X | Crystal structure of the extracellular segment of integrin alpha VBETA3 bound to MN2+ | x-ray diffraction | B | — | — |
| 1M1X | Crystal structure of the extracellular segment of integrin alpha VBETA3 bound to MN2+ | x-ray diffraction | B | — | — |
| 1M8O | Platelet integrin alfaIIb-beta3 cytoplasmic domain | solution nmr | B | — | — |
| 1M8O | Platelet integrin alfaiib-BETA3 cytoplasmic domain | solution nmr | B | — | — |
| 1MIZ | Crystal structure of an integrin beta3-talin chimera | x-ray diffraction | A | — | — |
| 1MIZ | Crystal structure of an integrin BETA3-talin chimera | x-ray diffraction | A | — | — |
| 1MK7 | Crystal structure of an integrin BETA3-talin chimera | x-ray diffraction | A, C | — | — |
| 1MK7 | Crystal structure of an integrin BETA3-talin chimera | x-ray diffraction | A, C | — | — |
| 1MK9 | Crystal structure of an integrin BETA3-talin chimera | x-ray diffraction | A, C, E, G | — | — |
| 1MK9 | Crystal structure of an integrin BETA3-talin chimera | x-ray diffraction | A, C, E, G | — | — |
| 1S4X | NMR Structure of the integrin B3 cytoplasmic domain in DPC micelles | solution nmr | A | — | — |
| 1S4X | NMR structure of the integrin B3 cytoplasmic domain in dpc micelles | solution nmr | A | — | — |
| 1TYE | Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the… | x-ray diffraction | B, D, F | — | — |
| 1TYE | Structural basis for allostery in integrins and binding of ligand- mimetic therapeutics to the… | x-ray diffraction | B, D, F | — | — |
| 1U8C | A novel adaptation of the integrin PSI domain revealed from its crystal structure | x-ray diffraction | B | — | — |
| 1U8C | A novel adaptation of the integrin psi domain revealed from its crystal structure | x-ray diffraction | B | — | — |
| 2H7D | Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase… | solution nmr | B | — | — |
| 2H7D | Solution structure of the talin F3 domain in complex with a chimeric BETA3 integrin-pip kinase… | solution nmr | B | — | — |
| 2H7E | Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase… | solution nmr | B | — | — |
| 2H7E | Solution structure of the talin F3 domain in complex with a chimeric BETA3 integrin-pip kinase… | solution nmr | B | — | — |
| 2K9J | Integrin alphaIIb-beta3 transmembrane complex | solution nmr | B | — | — |
| 2K9J | Integrin alphaiib-BETA3 transmembrane complex | solution nmr | B | — | — |
| 2KNC | Platelet integrin ALFAIIB-BETA3 transmembrane-cytoplasmic heterocomplex | solution nmr | B | — | — |
| 2KNC | Platelet integrin alfaiib-BETA3 transmembrane-cytoplasmic heterocomplex | solution nmr | B | — | — |
| 2KV9 | Integrin beta3 subunit in a disulfide linked alphaIIb-beta3 cytosolic domain | solution nmr | B | — | — |
| 2KV9 | Integrin BETA3 subunit in a disulfide linked alphaiib-BETA3 cytosolic domain | solution nmr | B | — | — |
| 2L1C | Shc-PTB:biphosphorylated integrin beta3 cytoplasmic tail complex (1:1) | solution nmr | B | — | — |
| 2L1C | Shc-PTB:BIPHOSPHORYLATED integrin BETA3 cytoplasmic tail complex (1:1) | solution nmr | B | — | — |
| 2L91 | Structure of the Integrin beta3 (A711P,K716A) Transmembrane Segment | solution nmr | A | — | — |
| 2L91 | Structure of the integrin BETA3 (A711P,K716A) transmembrane segment | solution nmr | A | — | — |
| 2LJD | monophosphorylated (747pY) beta3 integrin cytoplasmic tail under membrane mimetic conditions | solution nmr | A | — | — |
| 2LJD | Monophosphorylated (747PY) BETA3 integrin cytoplasmic tail under membrane mimetic conditions | solution nmr | A | — | — |
| 2LJE | Biphosphorylated (747pY, 759pY) beta3 integrin cytoplasmic tail under membrane mimetic conditions | solution nmr | A | — | — |
| 2LJE | Biphosphorylated (747PY, 759PY) BETA3 integrin cytoplasmic tail under membrane mimetic conditions | solution nmr | A | — | — |
| 2LJF | Monophosphorylated (747pY) beta3 integrin cytoplasmic tail under aqueous conditions | solution nmr | A | — | — |
| 2LJF | Monophosphorylated (747PY) BETA3 integrin cytoplasmic tail under aqueous conditions | solution nmr | A | — | — |
| 2MTP | The structure of Filamin repeat 21 bound to integrin | solution nmr | C | — | — |
| 2MTP | The structure of filamin repeat 21 bound to integrin | solution nmr | C | — | — |
| 2N9Y | Structure of the Integrin alphaIIb-beta3(A711P) Transmembrane Complex | solution nmr | B | — | — |
| 2N9Y | Structure of the integrin alphaiib-BETA3(A711P) transmembrane complex | solution nmr | B | — | — |
| 2Q6W | The structure of HLA-DRA, DRB3*0101 (DR52a) with bound platelet integrin peptide associated with… | x-ray diffraction | C, F | — | — |
| 2Q6W | The structure of HLA-dra, DRB3*0101 (DR52A) with bound platelet integrin peptide associated with… | x-ray diffraction | C, F | — | — |
| 2RMZ | Bicelle-embedded integrin beta3 transmembrane segment | solution nmr | A | — | — |
| 2RMZ | Bicelle-embedded integrin BETA3 transmembrane segment | solution nmr | A | — | — |
| 2RN0 | Micelle-embedded integrin beta3 transmembrane segment | solution nmr | A | — | — |
| 2RN0 | Micelle-embedded integrin BETA3 transmembrane segment | solution nmr | A | — | — |
| 2VC2 | Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist L-739758 | x-ray diffraction | B | — | — |
| 2VC2 | Re-refinement of integrin ALPHAIIBBETA3 headpiece bound to antagonist L-739758 | x-ray diffraction | B | — | — |
| 2VDK | Re-refinement of Integrin AlphaIIbBeta3 Headpiece | x-ray diffraction | B | — | — |
| 2VDK | Re-refinement of integrin ALPHAIIBBETA3 headpiece | x-ray diffraction | B | — | — |
| 2VDL | Re-refinement of Integrin AlphaIIbBeta3 Headpiece | x-ray diffraction | B | — | — |
| 2VDL | Re-refinement of integrin ALPHAIIBBETA3 headpiece | x-ray diffraction | B | — | — |
| 2VDM | Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Tirofiban | x-ray diffraction | B | — | — |
| 2VDM | Re-refinement of integrin ALPHAIIBBETA3 headpiece bound to antagonist tirofiban | x-ray diffraction | B | — | — |
119 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 47 records
- MN · Manganese (II) ion · in 26 records
- MG · Magnesium ion · in 22 records
- CA · Calcium ion · in 20 records
- CL · Chloride ion · in 18 records
- SO4 · Sulfate ion · in 7 records
- I7R · (4-{[(5S)-3-{4-[(E)-imino(4-methylpiperazin-1-yl) methyl]phenyl}-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid · in 3 records
- MWX · Fradafiban · in 3 records
- NB9 · Lamifiban · in 3 records
- I1F · {5-[N-(4-carbamimidoylbenzoyl)-4-nitro-L-phenylalanyl]-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl}acetic acid · in 2 records
- MV8 · (4-{[(5R)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)acetic acid · in 2 records
- MWO · (4-{[(5S)-3-(piperidin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid · in 2 records
- N9U · Roxifiban · in 2 records
- XQS · Sibrafiban (active form) · in 2 records
- 5YB · N-(4-carbamimidoylbenzoyl)-beta-alanyl-L-alpha-aspartyl-L-phenylalanine · in 1 record
- A1LU7 · 2-[(2~{R},5~{R},8~{S},11~{S})-8-(4-azanylbutyl)-11-(3-carbamimidamidopropyl)-3,6,9,12,15-pentakis(oxidanylidene)-5-(phenylmethyl)-1,4,7,10,13-pentazacyclopentadec-2-yl]ethanoic acid · in 1 record
- IR7 · (4-{[2-oxo-4-(piperidin-4-yl)piperazin-1-yl]acetyl}phenoxy)acetic acid · in 1 record
- JUY · (2S)-2-[(1,3-benzothiazole-2-carbonyl)amino]-4-{[5-(1, 8-naphthyridin-2-yl)pentanoyl]amino}butanoic acid · in 1 record
- M6K · (4-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid · in 1 record
- MJX · {4-[4-(4-carbamimidoylphenyl)piperazin-1-yl]piperidin-1-yl}acetic acid · in 1 record
- MPT · Beta-mercaptopropionic acid · in 1 record
- MWI · Lotrafiban · in 1 record
- NH2 · Amino group · in 1 record
- NJ9 · 3-(4-{[(5S)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)propanoic acid · in 1 record
- NJF · (1-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperidin-4-yl)acetic acid · in 1 record
Experiment against prediction
- 4HXJ chain C against the predicted model P05106: TM-score 1.00, RMSD 0.02 Å
- 3FCS chain D against the predicted model P05106: TM-score 0.99, RMSD 1.00 Å
- 8XEL chain B against the predicted model P05106: TM-score 0.99, RMSD 1.06 Å
- 8XEK chain B against the predicted model P05106: TM-score 0.98, RMSD 1.10 Å
- 3FCS chain B against the predicted model P05106: TM-score 0.97, RMSD 1.56 Å
- 4MMZ chain B against the predicted model P05106: TM-score 0.97, RMSD 1.73 Å
- 6NAJ chain B against the predicted model P05106: TM-score 0.97, RMSD 1.76 Å
- 4G1M chain B against the predicted model P05106: TM-score 0.97, RMSD 1.77 Å
- 4O02 chain B against the predicted model P05106: TM-score 0.97, RMSD 1.83 Å
- 1U8C chain B against the predicted model P05106: TM-score 0.96, RMSD 1.75 Å
Elsewhere
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