UniProt P05089
Arginase-1 (P05089)
Arginase-1 (UniProt P05089), EC 3.5.3.1: 102 experimental structures and 1 predicted model on GenesisL1, 18 ligands bound, 137 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P05089
- Protein
- Arginase-1
- EC
- 3.5.3.1
- Experimental structures
- 102
- Predicted models
- 1
- Ligands
- 18
- Pockets
- 137 · 8 records with a druggable one
Structures
103 records of P05089 in the MolNFT archive: 102 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WVA | Crystal structure of human arginase I from twinned crystal | x-ray diffraction | A, B | — | — |
| 1WVA | Crystal structure of human arginase I from twinned crystal | x-ray diffraction | A, B | — | — |
| 1WVB | Crystal structure of human arginase I: the mutant E256Q | x-ray diffraction | A, B | — | — |
| 1WVB | Crystal structure of human arginase I: the mutant E256Q | x-ray diffraction | A, B | — | — |
| 2AEB | Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune… | x-ray diffraction | A, B | — | — |
| 2AEB | Crystal structure of human arginase I at 1.29 a resolution and exploration of inhibition in immune… | x-ray diffraction | A, B | — | — |
| 2PHA | Crystal structure of native, unliganded human arginase at 1.90 resolution | x-ray diffraction | A, B | — | — |
| 2PHA | Crystal structure of native, unliganded human arginase at 1.90 resolution | x-ray diffraction | A, B | — | — |
| 2PHO | Crystal structure of human arginase I complexed with thiosemicarbazide at 1.95 resolution | x-ray diffraction | A, B | — | — |
| 2PHO | Crystal structure of human arginase I complexed with thiosemicarbazide at 1.95 resolution | x-ray diffraction | A, B | — | — |
| 2PLL | Crystal structure of perdeuterated human arginase I | x-ray diffraction | A, B | — | — |
| 2PLL | Crystal structure of perdeuterated human arginase I | x-ray diffraction | A, B | — | — |
| 2ZAV | Arginase I (homo sapiens): native and unliganded structure at 1.70 A resolution | x-ray diffraction | A, B | — | — |
| 2ZAV | Arginase I (homo sapiens): native and unliganded structure at 1.70 a resolution | x-ray diffraction | A, B | — | — |
| 3DJ8 | Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with… | x-ray diffraction | A, B | — | — |
| 3DJ8 | Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with… | x-ray diffraction | A, B | — | — |
| 3E6K | X-ray structure of Human Arginase I: the mutant D183A in complex with ABH | x-ray diffraction | A, B | — | — |
| 3E6K | X-ray structure of human arginase I: the mutant D183A in complex with abh | x-ray diffraction | A, B | — | — |
| 3E6V | X-ray structure of human arginase I-D183N mutant: the complex with ABH | x-ray diffraction | A, B | — | — |
| 3E6V | X-ray structure of human arginase I-D183N mutant: the complex with abh | x-ray diffraction | A, B | — | — |
| 3F80 | (S)-2-amino-6-nitrohexanoic acid binds to human arginase I through multiple nitro-metal… | x-ray diffraction | A, B | — | — |
| 3F80 | (S)-2-amino-6-nitrohexanoic acid binds to human arginase I through multiple nitro-metal… | x-ray diffraction | A, B | — | — |
| 3GMZ | Crystal of human arginase in complex with L-ornithine. Resolution 1.43 A. | x-ray diffraction | A, B | — | — |
| 3GMZ | Crystal of human arginase in complex with L-ornithine. resolution 1.43 a. | x-ray diffraction | A, B | — | — |
| 3GN0 | Crystal structure of human arginase I in complex with difluoromethylornithine (DFMO) | x-ray diffraction | A, B | — | — |
| 3GN0 | Crystal structure of human arginase I in complex with difluoromethylornithine (dfmo) | x-ray diffraction | A, B | — | — |
| 3KV2 | HIGH RESOLUTION STRUCTURE OF HUMAN ARGINASE I IN COMPLEX WITH THE STRONG INHIBITOR… | x-ray diffraction | A, B | — | — |
| 3KV2 | High resolution structure of human arginase I in complex with the strong inhibitor… | x-ray diffraction | A, B | — | — |
| 3LP4 | Crystal structure of human arginase I in complex with L-LYSINE, 1.90A Resolution. | x-ray diffraction | A, B | — | — |
| 3LP4 | Crystal structure of human arginase I in complex with L-lysine, 1.90A resolution. | x-ray diffraction | A, B | — | — |
| 3LP7 | Crystal structure of Human Arginase I in complex with inhibitor N(omega)-hydroxy-L-arginine (NOHA)… | x-ray diffraction | A, B | — | — |
| 3LP7 | Crystal structure of human arginase I in complex with inhibitor N(OMEGA)-hydroxy-L-arginine (noha)… | x-ray diffraction | A, B | — | — |
| 3MFV | Crystal structure of human arginase I in complex with 2-aminohomohistidine | x-ray diffraction | A, B | — | — |
| 3MFV | Crystal structure of human arginase I in complex with 2- aminohomohistidine | x-ray diffraction | A, B | — | — |
| 3MFW | Crystal structure of human arginase I in complex with L-2-aminohistidine and sulphate | x-ray diffraction | A, B | — | — |
| 3MFW | Crystal structure of human arginase I in complex with L-2- aminohistidine and sulphate | x-ray diffraction | A, B | — | — |
| 3MJL | Crystal structure of human arginase I in complex with 2-aminoimidazole. Resolution 1.90 A. | x-ray diffraction | A, B | — | — |
| 3MJL | Crystal structure of human arginase I in complex with 2- aminoimidazole. resolution 1.90 a. | x-ray diffraction | A, B | — | — |
| 3SJT | Crystal structure of human arginase I in complex with the inhibitor Me-ABH, Resolution 1.60 A… | x-ray diffraction | A, B | — | — |
| 3SJT | Crystal structure of human arginase I in complex with the inhibitor me-abh, resolution 1.60 a… | x-ray diffraction | A, B | — | — |
| 3SKK | Crystal structure of human arginase I in complex with the inhibitor FABH, Resolution 1.70 A… | x-ray diffraction | A, B | — | — |
| 3SKK | Crystal structure of human arginase I in complex with the inhibitor fabh, resolution 1.70 a… | x-ray diffraction | A, B | — | — |
| 3TF3 | Crystal structure of metal-free Human Arginase I | x-ray diffraction | A, B | — | — |
| 3TF3 | Crystal structure of metal-free human arginase I | x-ray diffraction | A, B | — | — |
| 3TH7 | Crystal structure of unliganded Co2+2-HAI (pH 7.0) | x-ray diffraction | A, B | — | — |
| 3TH7 | Crystal structure of unliganded CO2+2-hai (pH 7.0) | x-ray diffraction | A, B | — | — |
| 3THE | Crystal structure of Co2+2-HAI (pH 8.5) | x-ray diffraction | A, B | — | — |
| 3THE | Crystal structure of CO2+2-hai (pH 8.5) | x-ray diffraction | A, B | — | — |
| 3THH | Crystal structure of the Co2+2-HAI-ABH complex | x-ray diffraction | A, B | — | — |
| 3THH | Crystal structure of the CO2+2-hai-abh complex | x-ray diffraction | A, B | — | — |
| 3THJ | Crystal structure of the Co2+2-HAI-L-Orn complex | x-ray diffraction | A, B | — | — |
| 3THJ | Crystal structure of the CO2+2-hai-L-orn complex | x-ray diffraction | A, B | — | — |
| 4FCI | Crystal Structure of the Mn2+2-Human Arginase I-AGPA Complex | x-ray diffraction | A, B | — | — |
| 4FCI | Crystal structure of the MN2+2-human arginase I-agpa complex | x-ray diffraction | A, B | — | — |
| 4FCK | Crystal Structure of the Co2+2-Human Arginase I-AGPA Complex | x-ray diffraction | A, B | — | — |
| 4FCK | Crystal structure of the CO2+2-human arginase I-agpa complex | x-ray diffraction | A, B | — | — |
| 4GSM | Crystal Structure of Ni2+2-Human Arginase I | x-ray diffraction | A, B | — | — |
| 4GSM | Crystal structure of NI2+2-human arginase I | x-ray diffraction | A, B | — | — |
| 4GSV | Crystal Structure of the Ni2+2-Human Arginase I-ABH complex | x-ray diffraction | A, B | — | — |
| 4GSV | Crystal structure of the NI2+2-human arginase I-abh complex | x-ray diffraction | A, B | — | — |
43 records more on the page itself.
Ligands
- MN · Manganese (II) ion · in 28 records
- NA · Sodium ion · in 4 records
- 0IZ · 3-[(2~{S},3~{R},4~{R})-4-[[(2~{S})-2-azanyl-3-methyl-butanoyl]amino]-2-carboxy-pyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boron · in 2 records
- VUV · 3-[(2~{S},3~{R})-2-carboxypyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide · in 2 records
- VUY · 3-[(1~{S},2~{S},5~{R})-2-carboxy-6-thia-3-azabicyclo[3.2.0]heptan-1-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide · in 2 records
- XC3 · [(~{E})-3-[(3~{S},4~{R})-4-azanyl-1-[(2~{S})-2-azanylpropanoyl]-4-carboxy-pyrrolidin-3-yl]prop-1-enyl]-tris(oxidanyl)boranium · in 2 records
- XFG · 3-[(2~{S},3~{R},4~{R})-4-azanyl-2-carboxy-pyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boron · in 2 records
- O93 · 2-[(1~{R},3~{R},4~{S})-3-azanyl-3-carboxy-4-[(dimethylamino)methyl]cyclohexyl]ethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron · in 1 record
- QR1 · {3-[(3ar,4s,5s,6ar)-5-azaniumyl-5-carboxyoctahydrocyclopenta[c]pyrrol-2-ium-4-yl]propyl}(trihydroxy)borate(1-) · in 1 record
- QR4 · {3-[(3ar,4r,5s,6ar)-4-azaniumyl-4-carboxyoctahydrocyclopenta[b]pyrrol-1-ium-5-yl]propyl}(trihydroxy)borate(1-) · in 1 record
- QRA · 3-[(5~{S},7~{S},8~{S})-8-azanyl-8-carboxy-1-azaspiro[4.4]nonan-7-yl]propyl-$L^{3}-oxidanyl-bis(oxidanyl)boranuide · in 1 record
- QRJ · {3-[(5R,7S,8S)-8-azaniumyl-8-carboxy-2-azaspiro[4.4]nonan-2-ium-7-yl]propyl}(trihydroxy) borate(1-) · in 1 record
- UKR · 1-{[(3S,4S)-3-({4-[2-(4-fluorobenzene-1-sulfonyl)ethyl]piperidin-1-yl}methyl)-4-(3-fluorophenyl)pyrrolidin-1-yl]methyl}cyclopentane-1-carboxylic acid · in 1 record
- UL0 · 1-{[(3S,4S)-3-(3-fluorophenyl)-4-{[4-(1,3,4-triethyl-1H-pyrazol-5-yl)piperidin-1-yl]methyl}pyrrolidin-1-yl]methyl}cyclopentane-1-carboxylic acid · in 1 record
- VUS · 3-[(3~{A}~{S},4~{S},6~{A}~{R})-4-carboxy-2,3,4,5,6, 6~{A}-hexahydro-1~{H}-pyrrolo[2,3-c]pyrrol-3~{A}-yl]propyl-$L^{3}-oxidanyl-bis(oxidanyl)boranuide · in 1 record
- VV1 · 3-[(1~{S},2~{S},5~{R})-2-carboxy-3,6-diazabicyclo[3.2.0]heptan-1-yl]propyl-$L^{3}-oxidanyl-bis(oxidanyl)boranuide · in 1 record
- VV4 · 3-[(1~{R},5~{S},8~{R})-5-carboxy-2,6-diazabicyclo[3.2.1]octan-8-yl]propyl-$L^{3}-oxidanyl-bis(oxidanyl)boranuide · in 1 record
- XFP · 3-[(2~{S},3~{R})-2-carboxypiperidin-3-yl]propyl-$L^{3}-oxidanyl-bis(oxidanyl)boranuide · in 1 record
Experiment against prediction
- 3SJT chain B against the predicted model P05089: TM-score 1.00, RMSD 0.42 Å
- 3SJT chain B against the predicted model P05089: TM-score 1.00, RMSD 0.42 Å
- 3F80 chain B against the predicted model P05089: TM-score 1.00, RMSD 0.43 Å
- 3F80 chain B against the predicted model P05089: TM-score 1.00, RMSD 0.43 Å
- 3SJT chain A against the predicted model P05089: TM-score 1.00, RMSD 0.43 Å
- 3SJT chain A against the predicted model P05089: TM-score 1.00, RMSD 0.43 Å
- 3SKK chain B against the predicted model P05089: TM-score 1.00, RMSD 0.44 Å
- 3SKK chain B against the predicted model P05089: TM-score 1.00, RMSD 0.44 Å
- 3MJL chain B against the predicted model P05089: TM-score 1.00, RMSD 0.44 Å
- 3MJL chain B against the predicted model P05089: TM-score 1.00, RMSD 0.44 Å
Elsewhere
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