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Ligand · DMO

DMO · Alpha-difluoromethylornithine

DMO, Alpha-difluoromethylornithine (C6 H12 F2 N2 O2, 182.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
DMO
Formula
C6 H12 F2 N2 O2
Class
ligand
Structures
4
PDB entries
2

Binding sites

DMO in 4 structures; the first of them:

  • 2TOD · Ornithine decarboxylase from trypanosoma brucei K69A mutant in complex with… · DMO A700 · binds TYR323, CYS360, ASP361, PHE397, ARG277, TYR331, ASP332, TYR389
  • 3GN0 · Crystal structure of human arginase I in complex with difluoromethylornithine (DFMO) · DMO A551 · binds HIS126, ASP128, ASN130, THR135, THR136, SER137, ASN139, HIS141 and 4 more
  • 2TOD · Ornithine decarboxylase from trypanosoma brucei K69A mutant in complex with… · DMO A700 · binds TYR323, CYS360, ASP361, PHE397, ARG277, TYR331, ASP332, TYR389
  • 3GN0 · Crystal structure of human arginase I in complex with difluoromethylornithine (dfmo) · DMO A551 · binds HIS126, ASP128, ASN130, THR135, THR136, SER137, ASN139, HIS141 and 4 more

Residues it binds most

ASP 12, TYR 8, THR 4, ARG 8, ASN 4, CYS 8, HIS 4, PHE 8, GLU 4, GLY 4 (residue and the binding sites it lines).

Found with

  • PLP · Pyridoxal-5'-phosphate
  • MN · Manganese (II) ion

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