UniProt P03920
NADH-ubiquinone oxidoreductase chain 5 (P03920)
NADH-ubiquinone oxidoreductase chain 5 (UniProt P03920), EC 1.6.5.3, 7.1.1.2: 41 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 115 pockets. Binding sites, druggability and experiment against…
- UniProt
- P03920
- Protein
- NADH-ubiquinone oxidoreductase chain 5
- EC
- 1.6.5.3, 7.1.1.2
- Experimental structures
- 41
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 115 · 26 records with a druggable one
Structures
42 records of P03920 in the MolNFT archive: 41 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LC5 | Structure of mammalian respiratory complex I, CLASS2 | electron microscopy | L | — | — |
| 5LDW | Structure of mammalian respiratory Complex I, class1 | electron microscopy | L | — | — |
| 5LDW | Structure of mammalian respiratory complex I, CLASS1 | electron microscopy | L | — | — |
| 5LDX | Structure of mammalian respiratory complex I, CLASS3. | electron microscopy | L | — | — |
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | L | — | 5 (best 0.86) |
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | L | — | — |
| 7DGQ | Activity optimized supercomplex state1 | electron microscopy | 6 | CDL | 4 (best 0.87) |
| 7DGZ | Activity optimized complex I (closed form) | electron microscopy | 6 | CDL | — |
| 7DH0 | Activity optimized complex I (open form) | electron microscopy | 6 | CDL | — |
| 7DKF | Activity optimized supercomplex state4 | electron microscopy | 62 | CDL | 4 (best 0.90) |
| 7QSD | Bovine complex I in the active state at 3.1 A | electron microscopy | L | 3PE, CDL, EHZ, PC1 | 5 (best 0.87) |
| 7QSD | Bovine complex I in the active state at 3.1 a | electron microscopy | L | 3PE, CDL, EHZ, PC1 | — |
| 7QSK | Bovine complex I in lipid nanodisc, active-Q10 | electron microscopy | L | 3PE, CDL, EHZ, PC1, CHD, MYR | — |
| 7QSL | Bovine complex I in lipid nanodisc, active-apo | electron microscopy | L | CDL, 3PE, PC1, EHZ, CHD, MYR | — |
| 7QSM | Bovine complex I in lipid nanodisc, Deactive-ligand (composite) | electron microscopy | L | 3PE, CDL, PC1, EHZ, CHD, MYR | 5 (best 0.85) |
| 7QSM | Bovine complex I in lipid nanodisc, deactive-ligand (composite) | electron microscopy | L | 3PE, CDL, PC1, CHD, MYR | — |
| 7QSN | Bovine complex I in lipid nanodisc, deactive-apo | electron microscopy | L | 3PE, CDL, CHD, PC1, EHZ, MYR | — |
| 7QSO | Bovine complex I in lipid nanodisc, State 3 (Slack) | electron microscopy | L | 3PE, CDL, CHD, PC1, EHZ, MYR | — |
| 7QSO | Bovine complex I in lipid nanodisc, state 3 (slack) | electron microscopy | L | 3PE, CDL, CHD, PC1, EHZ, MYR | — |
| 7R41 | Bovine complex I in the presence of IM1761092, active class i (Composite map) | electron microscopy | L | CDL, 3PE, PC1, EHZ, MYR | 5 (best 0.86) |
| 7R43 | Bovine complex I in the presence of IM1761092, active class iii (Composite map) | electron microscopy | L | CDL, 3PE, PC1, EHZ, MYR | — |
| 7R44 | Bovine complex I in the presence of IM1761092, active class iv (Composite map) | electron microscopy | L | CDL, 3PE, PC1, EHZ, MYR | 4 (best 0.86) |
| 7R45 | Bovine complex I in the presence of IM1761092, deactive class i (Composite map) | electron microscopy | L | CDL, 3PE, PC1, EHZ, MYR | 4 (best 0.86) |
| 7R46 | Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) | electron microscopy | L | CDL, 3PE, EHZ, PC1, MYR | 3 (best 0.87) |
| 7R47 | Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) | electron microscopy | L | CDL, 3PE, PC1, EHZ, MYR | — |
| 7R48 | Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) | electron microscopy | L | CDL, 3PE, EHZ, PC1, MYR | 5 (best 0.85) |
| 7R4C | Bovine complex I in the presence of IM1761092, deactive class v (Composite map) | electron microscopy | L | 3PE, CDL, PC1, EHZ, MYR | 4 (best 0.85) |
| 7R4F | Bovine complex I in the presence of IM1761092, slack class i (Composite map) | electron microscopy | L | 3PE, CDL, PC1, EHZ, MYR | 4 (best 0.88) |
| 7R4G | Bovine complex I in the presence of IM1761092, slack class ii (Composite map) | electron microscopy | L | 3PE, CDL, PC1, EHZ, MYR | 4 (best 0.85) |
| 8Q0A | Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | L | 3PE, CDL, PC1, PLC, EHZ, CHD | 4 (best 0.87) |
| 8Q0F | Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | L | 3PE, CDL, PC1, PLC, EHZ, CHD | 4 (best 0.87) |
| 8Q0J | Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. | electron microscopy | L | EHZ, CHD, MYR | 5 (best 0.86) |
| 8Q0M | Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | L | 3PE, PC1, PLC, CDL, EHZ, CHD | 4 (best 0.86) |
| 8Q1P | Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially… | electron microscopy | L | 3PE, CDL, PC1, PLC, EHZ, CHD | 5 (best 0.87) |
| 8Q1U | Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially… | electron microscopy | L | 3PE, CDL, PC1, PLC, EHZ, CHD | 6 (best 0.86) |
| 8Q1Y | Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially… | electron microscopy | L | 3PE, PC1, PLC, EHZ, CDL, CHD | 4 (best 0.88) |
| 8Q25 | Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially… | electron microscopy | L | 3PE, CDL, PLC, PC1, EHZ, CHD | 5 (best 0.88) |
| 8Q46 | Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | L | 3PE, CDL, PLC, PC1, EHZ, CHD | 4 (best 0.86) |
| 8Q47 | Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. | electron microscopy | L | 3PE, CDL, PLC, PC1, EHZ, CHD | 4 (best 0.88) |
| 8Q49 | Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | L | 3PE, PC1, CHD, PLC, CDL, EHZ | 4 (best 0.88) |
| 8Q4A | Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | L | 3PE, CDL, PC1, PLC, EHZ, CHD | 4 (best 0.87) |
| P03920 | AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 5 (P03920) | predicted | A | — | 6 (best 0.57) |
Ligands
- CDL · Cardiolipin · in 34 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 30 records
- EHZ · ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate · in 30 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 30 records
- MYR · Myristic acid · in 29 records
- CHD · Cholic acid · in 19 records
- PLC · Diundecyl phosphatidyl choline · in 11 records
Experiment against prediction
- 7R4F chain L against the predicted model P03920: TM-score 1.00, RMSD 0.58 Å
- 7R4G chain L against the predicted model P03920: TM-score 1.00, RMSD 0.58 Å
- 7QSO chain L against the predicted model P03920: TM-score 1.00, RMSD 0.61 Å
- 7QSO chain L against the predicted model P03920: TM-score 1.00, RMSD 0.61 Å
- 8Q0J chain L against the predicted model P03920: TM-score 0.99, RMSD 0.88 Å
- 7QSN chain L against the predicted model P03920: TM-score 0.99, RMSD 1.01 Å
- 8Q4A chain L against the predicted model P03920: TM-score 0.99, RMSD 1.02 Å
- 7QSK chain L against the predicted model P03920: TM-score 0.99, RMSD 1.03 Å
- 7QSM chain L against the predicted model P03920: TM-score 0.99, RMSD 1.04 Å
- 7QSM chain L against the predicted model P03920: TM-score 0.99, RMSD 1.04 Å
Elsewhere
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