UniProt P00441
Superoxide dismutase [Cu-Zn] (P00441)
Superoxide dismutase [Cu-Zn] (UniProt P00441), EC 1.15.1.1: 233 experimental structures and 1 predicted model on GenesisL1, 27 ligands bound, 127 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P00441
- Protein
- Superoxide dismutase [Cu-Zn]
- EC
- 1.15.1.1
- Experimental structures
- 233
- Predicted models
- 1
- Ligands
- 27
- Pockets
- 127 · 12 records with a druggable one
Structures
234 records of P00441 in the MolNFT archive: 233 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AZV | Familial als mutant G37R cuznsod (human) | x-ray diffraction | A, B | — | — |
| 1AZV | Familial als mutant G37R cuznsod (human) | x-ray diffraction | A, B | — | — |
| 1BA9 | The solution structure of reduced monomeric superoxide dismutase, NMR, 36 structures | solution nmr | A | — | — |
| 1BA9 | The solution structure of reduced monomeric superoxide dismutase, NMR, 36 structures | solution nmr | A | — | — |
| 1DSW | The solution structure of a monomeric, reduced form of human copper, zinc superoxide dismutase… | solution nmr | A | — | — |
| 1DSW | The solution structure of a monomeric, reduced form of human copper, zinc superoxide dismutase… | solution nmr | A | — | — |
| 1FUN | Superoxide dismutase mutant with lys 136 replaced by glu, cys 6 replaced by ala and cys 111… | x-ray diffraction | A, F, B, G, C, H, D, I, E, J | — | — |
| 1FUN | Superoxide dismutase mutant with lys 136 replaced by glu, cys 6 replaced by ala and cys 111… | x-ray diffraction | A, F, B, G, C, H, D, I, E, J | — | — |
| 1HL4 | The Structure of Apo Type Human Cu, Zn Superoxide Dismutase | x-ray diffraction | A, B, C, D | — | — |
| 1HL4 | The structure of apo type human cu, zn superoxide dismutase | x-ray diffraction | A, B, C, D | — | — |
| 1HL5 | The Structure of Holo Type Human Cu, Zn Superoxide Dismutase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, S | — | — |
| 1HL5 | The structure of holo type human cu, zn superoxide dismutase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, S | — | — |
| 1KMG | The Solution Structure Of Monomeric Copper-free Superoxide Dismutase | solution nmr | A | — | — |
| 1KMG | The solution structure of monomeric copper-free superoxide dismutase | solution nmr | A | — | — |
| 1L3N | The Solution Structure of Reduced Dimeric Copper Zinc SOD: the Structural Effects of Dimerization | solution nmr | A, B | — | — |
| 1L3N | The solution structure of reduced dimeric copper zinc sod: the structural effects of dimerization | solution nmr | A, B | — | — |
| 1MFM | Monomeric human sod mutant F50E/G51E/E133Q at atomic resolution | x-ray diffraction | A | — | — |
| 1MFM | Monomeric human sod mutant F50E/G51E/E133Q at atomic resolution | x-ray diffraction | A | — | — |
| 1N18 | Thermostable mutant of Human Superoxide Dismutase, C6A, C111S | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 1N18 | Thermostable mutant of human superoxide dismutase, C6A, C111S | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 1N19 | Structure of the HSOD A4V mutant | x-ray diffraction | A, B | — | — |
| 1N19 | Structure of the hsod A4V mutant | x-ray diffraction | A, B | — | — |
| 1OEZ | Zn His46Arg mutant of Human Cu, Zn Superoxide Dismutase | x-ray diffraction | W, X, Y, Z | — | — |
| 1OEZ | Zn HIS46ARG mutant of human cu, zn superoxide dismutase | x-ray diffraction | W, X, Y, Z | — | — |
| 1OZT | Crystal Structure of apo-H46R Familial ALS Mutant human Cu,Zn Superoxide Dismutase (CuZnSOD) to… | x-ray diffraction | M, N, G, H, K, L, I, J | — | — |
| 1OZT | Crystal structure of apo-H46R familial als mutant human CU,ZN superoxide dismutase (cuznsod) to… | x-ray diffraction | M, N, G, H, K, L, I, J | — | — |
| 1OZU | Crystal Structure of Familial ALS Mutant S134N of human Cu,Zn Superoxide Dismutase (CuZnSOD) to… | x-ray diffraction | A, B | — | — |
| 1OZU | Crystal structure of familial als mutant S134N of human CU,ZN superoxide dismutase (cuznsod) to… | x-ray diffraction | A, B | — | — |
| 1P1V | Crystal Structure of FALS-associated human Copper-Zinc Superoxide Dismutase (CuZnSOD) Mutant D125H… | x-ray diffraction | A, B, C | — | — |
| 1P1V | Crystal structure of fals-associated human copper-zinc superoxide dismutase (cuznsod) mutant D125H… | x-ray diffraction | A, B, C | — | — |
| 1PTZ | Crystal structure of the human CU, Zn Superoxide Dismutase, Familial Amyotrophic Lateral Sclerosis… | x-ray diffraction | A, B | — | — |
| 1PTZ | Crystal structure of the human cu, zn superoxide dismutase, familial amyotrophic lateral sclerosis… | x-ray diffraction | A, B | — | — |
| 1PU0 | Structure of Human Cu,Zn Superoxide Dismutase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 1PU0 | Structure of human CU,ZN superoxide dismutase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 1RK7 | Solution structure of apo Cu,Zn Superoxide Dismutase: role of metal ions in protein folding | solution nmr | A | — | — |
| 1RK7 | Solution structure of apo CU,ZN superoxide dismutase: role of metal ions in protein folding | solution nmr | A | — | — |
| 1SOS | Atomic structures of wild-type and thermostable mutant recombinant human cu, zn superoxide dismutase | x-ray diffraction | A, F, B, G, C, H, D, I, E, J | — | — |
| 1SOS | Atomic structures of wild-type and thermostable mutant recombinant human cu, zn superoxide dismutase | x-ray diffraction | A, F, B, G, C, H, D, I, E, J | — | — |
| 1SPD | Amyotrophic lateral sclerosis and structural defects in CU,ZN superoxide dismutase | x-ray diffraction | A, B | — | — |
| 1SPD | Amyotrophic lateral sclerosis and structural defects in CU,ZN superoxide dismutase | x-ray diffraction | A, B | — | — |
| 1UXL | I113T mutant of human SOD1 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 1UXL | I113T mutant of human SOD1 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 1UXM | A4V mutant of human SOD1 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1UXM | A4V mutant of human SOD1 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 2AF2 | Solution structure of disulfide reduced and copper depleted Human Superoxide Dismutase | solution nmr | A, B | — | — |
| 2AF2 | Solution structure of disulfide reduced and copper depleted human superoxide dismutase | solution nmr | A, B | — | — |
| 2C9S | 1.24 Angstroms resolution structure of Zn-Zn Human Superoxide dismutase | x-ray diffraction | A, F | — | — |
| 2C9S | 1.24 ångströms resolution structure of zn-zn human superoxide dismutase | x-ray diffraction | A, F | — | — |
| 2C9U | 1.24 Angstroms resolution structure of as-isolated Cu-Zn Human Superoxide dismutase | x-ray diffraction | A, F | — | — |
| 2C9U | 1.24 ångströms resolution structure of as-isolated cu-zn human superoxide dismutase | x-ray diffraction | A, F | — | — |
| 2C9V | Atomic resolution structure of Cu-Zn Human Superoxide dismutase | x-ray diffraction | A, F | — | — |
| 2C9V | Atomic resolution structure of cu-zn human superoxide dismutase | x-ray diffraction | A, F | — | — |
| 2GBT | C6A/C111A CuZn Superoxide dismutase | x-ray diffraction | A, B, C, D | — | — |
| 2GBT | C6A/C111A cuzn superoxide dismutase | x-ray diffraction | A, B, C, D | — | — |
| 2GBU | C6A/C111A/C57A/C146A apo CuZn Superoxide dismutase | x-ray diffraction | A, B, C, D | — | — |
| 2GBU | C6A/C111A/C57A/C146A apo cuzn superoxide dismutase | x-ray diffraction | A, B, C, D | — | — |
| 2GBV | C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 2GBV | C6A/C111A/C57A/C146A holo cuzn superoxide dismutase | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 2LU5 | Structure and chemical shifts of Cu(I),Zn(II) superoxide dismutase by solid-state NMR | solid-state nmr | A | — | — |
| 2LU5 | Structure and chemical shifts of CU(I),ZN(II) superoxide dismutase by solid-state NMR | solid-state nmr | A | — | — |
174 records more on the page itself.
Ligands
- ZN · Zinc ion · in 39 records
- SO4 · Sulfate ion · in 15 records
- CU · Copper (II) ion · in 8 records
- CL · Chloride ion · in 5 records
- S4P · Dihydrogen tetrasulfide · in 5 records
- 9JT · ~{N}-phenyl-2-selanyl-benzamide · in 3 records
- 5FW · Isoprenaline · in 2 records
- 6B3 · 2'-[(6-oxo-5,6-dihydrophenanthridin-3-yl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid · in 2 records
- 946 · 4-[(1~{R})-2-(naphthalen-2-ylmethylamino)-1-oxidanyl-ethyl]benzene-1,2-diol · in 2 records
- LQW · ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide · in 2 records
- PS5 · Pentasulfide-sulfur · in 2 records
- TAM · Tris(hydroxyethyl)aminomethane · in 2 records
- 9JK · ~{N}-phenyl-2-sulfanyl-benzamide · in 1 record
- A1LYN · (2S)-decane-1,2,10-triol · in 1 record
- D7Z · Ptcl2(1(r),2(r)-dach) · in 1 record
- IOD · Iodide ion · in 1 record
- K4I · (9~{R})-3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-9-oxidanyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one · in 1 record
- LQN · 2-selanyl-~{N}-[3-[4-(trifluoromethyl) phenyl]phenyl]benzamide · in 1 record
- LR2 · ~{N}-pyridin-2-yl-2-selanyl-benzamide · in 1 record
- NA · Sodium ion · in 1 record
- ORA · 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid · in 1 record
- Q7N · ~{N}-[(3-methoxyphenyl)methyl]-2-selanyl-benzamide · in 1 record
- Q7T · ~{N}-(phenylmethyl)-2-selanyl-benzamide · in 1 record
- Q7W · ~{N}-[(3-chlorophenyl)methyl]-2-selanyl-benzamide · in 1 record
- Q8H · ~{N}-(pyridin-3-ylmethyl)-2-selanyl-benzamide · in 1 record
- SE · Selenium atom · in 1 record
- UDI · butane-1,4-dithiol · in 1 record
Experiment against prediction
- 6Z4K chain AAA against the predicted model P00441: TM-score 1.00, RMSD 0.25 Å
- 2WZ0 chain A against the predicted model P00441: TM-score 1.00, RMSD 0.25 Å
- 6Z4O chain BBB against the predicted model P00441: TM-score 1.00, RMSD 0.27 Å
- 2WYT chain A against the predicted model P00441: TM-score 1.00, RMSD 0.27 Å
- 2ZKY chain A against the predicted model P00441: TM-score 1.00, RMSD 0.27 Å
- 2C9V chain A against the predicted model P00441: TM-score 1.00, RMSD 0.28 Å
- 1HL5 chain F against the predicted model P00441: TM-score 1.00, RMSD 0.27 Å
- 1HL4 chain A against the predicted model P00441: TM-score 1.00, RMSD 0.28 Å
- 2WYZ chain A against the predicted model P00441: TM-score 1.00, RMSD 0.29 Å
- 2GBT chain A against the predicted model P00441: TM-score 1.00, RMSD 0.29 Å
Elsewhere
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