UniProt O75581
O75581
O75581 (UniProt O75581): 28 experimental structures on GenesisL1, 7 ligands bound. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O75581
- Experimental structures
- 28
- Predicted models
- 0
- Ligands
- 7
Structures
28 records of O75581 in the MolNFT archive: 28 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3S2K | Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. | x-ray diffraction | A, B | — | — |
| 3S2K | Structural basis of wnt signaling inhibition by dickkopf binding to LRP5/6. | x-ray diffraction | A, B | — | — |
| 3S8V | Crystal structure of LRP6-Dkk1 complex | x-ray diffraction | A, B | — | — |
| 3S8V | Crystal structure of LRP6-DKK1 complex | x-ray diffraction | A, B | — | — |
| 3S8Z | Crystal structure of LRP6-E3E4 | x-ray diffraction | A | — | — |
| 3S8Z | Crystal structure of LRP6-E3E4 | x-ray diffraction | A | — | — |
| 3S94 | Crystal structure of LRP6-E1E2 | x-ray diffraction | A, B | — | — |
| 3S94 | Crystal structure of LRP6-E1E2 | x-ray diffraction | A, B | — | — |
| 3SOB | The structure of the first YWTD beta propeller domain of LRP6 in complex with a FAB | x-ray diffraction | B | — | — |
| 3SOB | The structure of the first ywtd beta propeller domain of LRP6 in complex with a Fab | x-ray diffraction | B | — | — |
| 3SOQ | The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide | x-ray diffraction | A | — | — |
| 3SOQ | The structure of the first ywtd beta propeller domain of LRP6 in complex with a DKK1 peptide | x-ray diffraction | A | — | — |
| 3SOV | The structure of a beta propeller domain in complex with peptide S | x-ray diffraction | A | — | — |
| 3SOV | The structure of a beta propeller domain in complex with peptide S | x-ray diffraction | A | — | — |
| 4A0P | Crystal structure of LRP6P3E3P4E4 | x-ray diffraction | A | — | — |
| 4A0P | Crystal structure of LRP6P3E3P4E4 | x-ray diffraction | A | — | — |
| 4DG6 | Crystal structure of domains 1 and 2 of LRP6 | x-ray diffraction | A | — | — |
| 4DG6 | Crystal structure of domains 1 and 2 of LRP6 | x-ray diffraction | A | — | — |
| 5AIR | Structural analysis of mouse GSK3beta fused with LRP6 peptide. | x-ray diffraction | A, B | — | — |
| 5AIR | Structural analysis of mouse GSK3BETA fused with LRP6 peptide. | x-ray diffraction | A, B | — | — |
| 5FWW | Wnt modulator kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4) | x-ray diffraction | A | — | — |
| 5GJE | Three-dimensional reconstruction of human LRP6 ectodomain complexed with DKK1 | electron microscopy | A, B | — | — |
| 6H15 | Structure of LRP6 P3E3P4E4 in complex with vhh L-P2-B10 | x-ray diffraction | A, B | NAG, CL | — |
| 6H16 | Structure of LRP6 P3E3P4E4 in complex with vhh L-P2-D07 | x-ray diffraction | A | NAG, BMA, CA | — |
| 6L6R | Crystal structure of LRP6 E1E2-sost complex | x-ray diffraction | A, B | NAG, FUC, MG | — |
| 7NAM | LRP6_E1 in complex with lr-eet-3.5 | x-ray diffraction | A | NAG, FUC, NA | — |
| 8DVL | Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.18 | x-ray diffraction | A | NAG, FUC, CA | — |
| O75581 | AlphaFold monomer V2.0 prediction for low-density lipoprotein receptor-related protein 6 (O75581) | — | — | — |
Ligands
Experiment against prediction
- 5AIR chain A against the predicted model Q9WV60: TM-score 0.99, RMSD 0.87 Å
- 5AIR chain A against the predicted model Q9WV60: TM-score 0.99, RMSD 0.87 Å
- 5AIR chain B against the predicted model Q9WV60: TM-score 0.98, RMSD 1.02 Å
- 5AIR chain B against the predicted model Q9WV60: TM-score 0.98, RMSD 1.02 Å
Elsewhere
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