MolNFT v1 · #182974 · protein
LRP6_E1 in complex with lr-eet-3.5
7NAM · Low-density lipoprotein receptor-related protein 6: “LRP6_E1 in complex with lr-eet-3.5”. X-ray diffraction, 4 ligands (NAG, FUC, MAN), 1 pocket (best druggability 0.76). MolNFT v1 #182974 on GenesisL1: 3D structure, binding sites…
- PDB
- 7NAM
- Type
- protein
- Length
- 339 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Low-density lipoprotein receptor-related protein 6; Trypsin inhibitor 2
- UniProt
- O75581
- Ligands
- NAG, FUC, MAN, NA
- Pockets
- 1 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Low-density lipoprotein receptor-related protein 6 | protein | 307 | 3% helix, 49% strand | O75581 |
| B | Trypsin inhibitor 2 | protein | 32 | 9% helix, 13% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A
- FUC · alpha-L-fucopyranose · sugar · 4 copies · chains A
- MAN · alpha-D-mannopyranose · sugar · 2 copies · chains A
- NA · Sodium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.76 | 0.97 | 32 | NA |
Interfaces
1 interface between chains.
- A–B · 596 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75581
- Elsewhere: RCSB PDB 7NAM · PDBe 7NAM · UniProt O75581
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