The structure of a beta propeller domain in complex with peptide S

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 48% strand (DSSP).

Ligands and binding sites

• FUC · alpha-L-fucopyranose · sugar · 4 copies · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
• GOL · Glycerol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–Z · 439 Ų buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

• 3SOV · The structure of a beta propeller domain in complex with peptide S · the same entry in another collection · chain A against A, TM-score 1.00
• O75581 · AlphaFold monomer V2.0 prediction for low-density lipoprotein receptor-related protein 6… · a predicted model of the same protein · chain A against A, TM-score 0.99
• Q9BQB4 · AlphaFold monomer V2.0 prediction for sclerostin (Q9BQB4) · a predicted model of the same protein · chain Z against A, TM-score 0.46

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O75581
• Every structure of UniProt Q9BQB4
• Elsewhere: RCSB PDB 3SOV · PDBe 3SOV · UniProt O75581 · UniProt Q9BQB4