UniProt O75208
Ubiquinone biosynthesis protein COQ9, mitochondrial (O75208)
Ubiquinone biosynthesis protein COQ9, mitochondrial (UniProt O75208): 8 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O75208
- Protein
- Ubiquinone biosynthesis protein COQ9, mitochondrial
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 52 · 3 records with a druggable one
Structures
9 records of O75208 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4RHP | Crystal structure of human COQ9 in complex with a phospholipid, Northeast Structural Genomics… | x-ray diffraction | A, B | — | — |
| 4RHP | Crystal structure of human COQ9 in complex with a phospholipid, northeast structural genomics… | x-ray diffraction | A, B | — | — |
| 6AWL | Crystal structure of human Coq9 | x-ray diffraction | A, B | PEF | — |
| 6AWL | Crystal structure of human COQ9 | x-ray diffraction | A, B | PEF | — |
| 6DEW | Structure of human COQ9 protein with bound isoprene. | x-ray diffraction | A, B, C, D, E, F | SO4, 64Z, N1S, FOF, FOH | 17 (best 0.81) |
| 6DEW | Structure of human COQ9 protein with bound isoprene. | x-ray diffraction | A, B, C, D, E, F | SO4, 64Z, N1S, FOF, FOH | — |
| 7SSP | Structure of the human COQ7:COQ9 complex by single-particle electron cryo-microscopy, unliganded… | electron microscopy | A, B, C, D | — | 15 (best 0.83) |
| 7SSS | Structure of the NADH-bound human COQ7:COQ9 complex by single-particle electron cryo-microscopy | electron microscopy | A, B, C, D | PEV, 8PP | 20 (best 0.79) |
| O75208 | AlphaFold monomer V2.0 prediction for ubiquinone biosynthesis protein COQ9, mitochondrial (O75208) | predicted | A | — | — |
Ligands
- 64Z · Geraniol · in 2 records
- FOF · (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol · in 2 records
- FOH · (2Z,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol · in 2 records
- N1S · (2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol · in 2 records
- PEF · Di-palmitoyl-3-sn-phosphatidylethanolamine · in 2 records
- SO4 · Sulfate ion · in 2 records
- 8PP · 2-[(2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaenyl]phenol · in 1 record
- PEV · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 1 record
Experiment against prediction
- 7SSS chain C against the predicted model O75208: TM-score 0.98, RMSD 0.64 Å
- 7SSS chain A against the predicted model O75208: TM-score 0.98, RMSD 0.65 Å
- 7SSS chain D against the predicted model O75208: TM-score 0.98, RMSD 0.66 Å
- 7SSS chain B against the predicted model O75208: TM-score 0.98, RMSD 0.69 Å
- 4RHP chain A against the predicted model O75208: TM-score 0.97, RMSD 1.44 Å
- 4RHP chain A against the predicted model O75208: TM-score 0.97, RMSD 1.44 Å
- 6DEW chain B against the predicted model O75208: TM-score 0.97, RMSD 1.39 Å
- 6DEW chain B against the predicted model O75208: TM-score 0.97, RMSD 1.39 Å
- 6DEW chain E against the predicted model O75208: TM-score 0.96, RMSD 1.20 Å
- 6DEW chain E against the predicted model O75208: TM-score 0.96, RMSD 1.20 Å
Elsewhere
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