MolNFT v1 · #143336 · protein
Crystal structure of human COQ9
6AWL · Ubiquinone biosynthesis protein COQ9, mitochondrial: “Crystal structure of human COQ9”. X-ray diffraction, 1 ligand (PEF), 2 pockets (best druggability 0.84). MolNFT v1 #143336 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6AWL
- Type
- protein
- Length
- 408 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquinone biosynthesis protein COQ9, mitochondrial
- UniProt
- O75208
- Ligands
- PEF
- Pockets
- 2 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquinone biosynthesis protein COQ9, mitochondrial | protein | 217 | 79% helix, 0% strand | O75208 |
| B | Ubiquinone biosynthesis protein COQ9, mitochondrial | protein | 191 | 77% helix, 0% strand | O75208 |
Ligands and binding sites
- PEF · Di-palmitoyl-3-sn-phosphatidylethanolamine · ligand · chains A, B
- BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 847 | 0.84 | 0.85 | 60 | PEF |
| 2 | 50 | 0.26 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 818 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75208
- Elsewhere: RCSB PDB 6AWL · PDBe 6AWL · UniProt O75208
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