UniProt O75164
Lysine-specific demethylase 4A (O75164)
Lysine-specific demethylase 4A (UniProt O75164), EC 1.14.11.-, 1.14.11.27: 167 experimental structures on GenesisL1, 45 ligands bound, 222 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O75164
- Protein
- Lysine-specific demethylase 4A
- EC
- 1.14.11.-, 1.14.11.27, 1.14.11.66, 1.14.11.69
- Experimental structures
- 167
- Predicted models
- 0
- Ligands
- 45
- Pockets
- 222 · 18 records with a druggable one
Structures
167 records of O75164 in the MolNFT archive: 167 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2GF7 | Double tudor domain structure | x-ray diffraction | A, B, C, D | — | — |
| 2GF7 | Double tudor domain structure | x-ray diffraction | A, B, C, D | — | — |
| 2GFA | double tudor domain complex structure | x-ray diffraction | A, B | — | — |
| 2GFA | Double tudor domain complex structure | x-ray diffraction | A, B | — | — |
| 2GP3 | Crystal structure of the catalytic core domain of jmjd2a | x-ray diffraction | A, B | — | — |
| 2GP3 | Crystal structure of the catalytic core domain of JMJD2A | x-ray diffraction | A, B | — | — |
| 2GP5 | Crystal structure of catalytic core domain of jmjd2A complexed with alpha-Ketoglutarate | x-ray diffraction | A, B | — | — |
| 2GP5 | Crystal structure of catalytic core domain of JMJD2A complexed with alpha-ketoglutarate | x-ray diffraction | A, B | — | — |
| 2OQ6 | Crystal structure of JMJD2A complexed with histone H3 peptide trimethylated at Lys9 | x-ray diffraction | A, B | — | — |
| 2OQ6 | Crystal structure of JMJD2A complexed with histone H3 peptide trimethylated at LYS9 | x-ray diffraction | A, B | — | — |
| 2OQ7 | The crystal structure of JMJD2A complexed with Ni and N-oxalylglycine | x-ray diffraction | A, B | — | — |
| 2OQ7 | The crystal structure of JMJD2A complexed with ni and N-oxalylglycine | x-ray diffraction | A, B | — | — |
| 2OS2 | Crystal structure of JMJD2A complexed with histone H3 peptide trimethylated at Lys36 | x-ray diffraction | A, B | — | — |
| 2OS2 | Crystal structure of JMJD2A complexed with histone H3 peptide trimethylated at LYS36 | x-ray diffraction | A, B | — | — |
| 2OT7 | Crystal structure of JMJD2A complexed with histone H3 peptide monomethylated at Lys9 | x-ray diffraction | A, B | — | — |
| 2OT7 | Crystal structure of JMJD2A complexed with histone H3 peptide monomethylated at LYS9 | x-ray diffraction | A, B | — | — |
| 2OX0 | Crystal structure of JMJD2A complexed with histone H3 peptide dimethylated at Lys9 | x-ray diffraction | A, B | — | — |
| 2OX0 | Crystal structure of JMJD2A complexed with histone H3 peptide dimethylated at LYS9 | x-ray diffraction | A, B | — | — |
| 2P5B | The complex structure of JMJD2A and trimethylated H3K36 peptide | x-ray diffraction | A, B | — | — |
| 2P5B | The complex structure of JMJD2A and trimethylated H3K36 peptide | x-ray diffraction | A, B | — | — |
| 2PXJ | The complex structure of JMJD2A and monomethylated H3K36 peptide | x-ray diffraction | A, B | — | — |
| 2PXJ | The complex structure of JMJD2A and monomethylated H3K36 peptide | x-ray diffraction | A, B | — | — |
| 2Q8C | Crystal structure of JMJD2A in ternary complex with an histone H3K9me3 peptide and 2-oxoglutarate | x-ray diffraction | A, B | — | — |
| 2Q8C | Crystal structure of JMJD2A in ternary complex with an histone H3K9ME3 peptide and 2-oxoglutarate | x-ray diffraction | A, B | — | — |
| 2Q8D | Crystal structure of JMJ2D2A in ternary complex with histone H3-K36me2 and succinate | x-ray diffraction | A, B | — | — |
| 2Q8D | Crystal structure of JMJ2D2A in ternary complex with histone H3-K36ME2 and succinate | x-ray diffraction | A, B | — | — |
| 2Q8E | Specificity and Mechanism of JMJD2A, a Trimethyllysine-Specific Histone Demethylase | x-ray diffraction | A, B | — | — |
| 2Q8E | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase | x-ray diffraction | A, B | — | — |
| 2QQR | JMJD2A hybrid tudor domains | x-ray diffraction | A, B | — | — |
| 2QQR | JMJD2A hybrid tudor domains | x-ray diffraction | A, B | — | — |
| 2QQS | JMJD2A tandem tudor domains in complex with a trimethylated histone H4-K20 peptide | x-ray diffraction | A, B | — | — |
| 2QQS | JMJD2A tandem tudor domains in complex with a trimethylated histone H4-K20 peptide | x-ray diffraction | A, B | — | — |
| 2VD7 | Crystal Structure of JMJD2A complexed with inhibitor Pyridine-2,4- dicarboxylic acid | x-ray diffraction | A, B | — | — |
| 2VD7 | Crystal structure of JMJD2A complexed with inhibitor pyridine-2,4- dicarboxylic acid | x-ray diffraction | A, B | — | — |
| 2WWJ | Structure of JMJD2A complexed with inhibitor 10A | x-ray diffraction | A, B | — | — |
| 2WWJ | Structure of JMJD2A complexed with inhibitor 10A | x-ray diffraction | A, B | — | — |
| 2YBK | JMJD2A complexed with R-2-hydroxyglutarate | x-ray diffraction | A, B | — | — |
| 2YBK | JMJD2A complexed with R-2-hydroxyglutarate | x-ray diffraction | A, B | — | — |
| 2YBP | JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41) | x-ray diffraction | A, B | — | — |
| 2YBP | JMJD2A complexed with R-2-hydroxyglutarate and histone H3K36ME3 peptide (30-41) | x-ray diffraction | A, B | — | — |
| 2YBS | JMJD2A COMPLEXED WITH S-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41) | x-ray diffraction | A, B | — | — |
| 2YBS | JMJD2A complexed with S-2-hydroxyglutarate and histone H3K36ME3 peptide (30-41) | x-ray diffraction | A, B | — | — |
| 3NJY | Crystal structure of JMJD2A complexed with 5-carboxy-8-hydroxyquinoline | x-ray diffraction | A, B | — | — |
| 3NJY | Crystal structure of JMJD2A complexed with 5-carboxy-8- hydroxyquinoline | x-ray diffraction | A, B | — | — |
| 3PDQ | Crystal structure of JMJD2A complexed with bipyridyl inhibitor | x-ray diffraction | A, B | — | — |
| 3PDQ | Crystal structure of JMJD2A complexed with bipyridyl inhibitor | x-ray diffraction | A, B | — | — |
| 3RVH | Crystal Structure of JMJD2A Complexed with Inhibitor | x-ray diffraction | A, B | — | — |
| 3RVH | Crystal structure of JMJD2A complexed with inhibitor | x-ray diffraction | A, B | — | — |
| 3U4S | Histone Lysine demethylase JMJD2A in complex with T11C peptide substrate crosslinked to… | x-ray diffraction | A, B | — | — |
| 3U4S | Histone lysine demethylase JMJD2A in complex with T11C peptide substrate crosslinked to… | x-ray diffraction | A, B | — | — |
| 4AI9 | JMJD2A Complexed with Daminozide | x-ray diffraction | A, B | — | — |
| 4AI9 | JMJD2A complexed with daminozide | x-ray diffraction | A, B | — | — |
| 4BIS | JMJD2A complexed with 8-hydroxyquinoline-4-carboxylic acid | x-ray diffraction | A, B | — | — |
| 4BIS | JMJD2A complexed with 8-hydroxyquinoline-4-carboxylic acid | x-ray diffraction | A, B | — | — |
| 4GD4 | Crystal Structure of JMJD2A Complexed with Inhibitor | x-ray diffraction | A, B | — | — |
| 4GD4 | Crystal structure of JMJD2A complexed with inhibitor | x-ray diffraction | A, B | — | — |
| 4URA | Crystal structure of human JMJD2A in complex with compound 14a | x-ray diffraction | A, B | — | — |
| 4URA | Crystal structure of human JMJD2A in complex with compound 14A | x-ray diffraction | A, B | — | — |
| 4V2V | JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (25-29) ARK(me3)SA | x-ray diffraction | A, B | — | — |
| 4V2V | JMJD2A complexed with NI(II), nog and histone H3K27ME3 peptide (25-29) ARK(ME3)SA | x-ray diffraction | A, B | — | — |
107 records more on the page itself.
Ligands
- ZN · Zinc ion · in 63 records
- CL · Chloride ion · in 33 records
- NI · Nickel (II) ion · in 30 records
- SO4 · Sulfate ion · in 8 records
- OGA · N-oxalylglycine · in 6 records
- FO2 · 8-[4-(1-methylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 4 records
- 48V · {[(2R)-2,3-diamino-3-oxopropyl]sulfanyl}acetic acid · in 2 records
- 92Y · (1R,2S,3R,4S)-3-[(dimethylamino)methyl]-1-phenylbicyclo[2.2.1]heptan-2-ol · in 2 records
- 9DJ · 3-[({(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl}methyl)amino]pyridine-4-carboxylic acid · in 2 records
- 9FJ · 3-({[(1R)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]methyl}amino)pyridine-4-carboxylic acid · in 2 records
- AKG · 2-oxoglutaric acid · in 2 records
- DHB · 3,4-dihydroxybenzoic acid · in 2 records
- FO8 · 8-[4-[2-[4-[4-(2-morpholin-4-ylethyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 2 records
- FOW · 8-[4-(2-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylethyl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 2 records
- FQ5 · 8-[4-[2-[4-(3-chlorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 2 records
- FQB · 8-[4-[2-[4-[4-[2-(dimethylamino)ethyl]phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 2 records
- FQE · 8-[4-[2-[4-[3-[2-(dimethylamino)ethyl]phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 2 records
- FQH · 8-[4-[2-[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 2 records
- FQQ · 8-[4-[2-[4-(3-chlorophenyl)-4-methyl-piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 2 records
- FUM · Fumaric acid · in 2 records
- MN · Manganese (II) ion · in 2 records
- MY7 · 2-(3-methyl-5-oxidanylidene-4-phenyl-4~{H}-pyrazol-1-yl)-3~{H}-benzimidazole-5-carboxylic acid · in 2 records
- QC1 · 3-{[(4-fluorophenyl)methyl]amino}pyridine-4-carboxylic acid · in 2 records
- QC2 · 2-[5-(3-hydroxyphenyl)-1H-pyrazol-1-yl]pyridine-4-carboxylic acid · in 2 records
- 1KA · (2-hydroxyethoxy)acetaldehyde · in 1 record
- 5TZ · 2-(2-azanyl-1,3-thiazol-4-yl)pyridine-4-carboxylic acid · in 1 record
- 5U8 · 8-[4-[2-[(4-fluorophenyl)methyl-methyl-amino]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 1 record
- 5UB · 8-(1,3-thiazol-4-yl)-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 1 record
- 5UJ · 8-[4-[2-[4-[3,5-bis(chloranyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 1 record
- 5UL · 8-[4-[2-[4-[(4-chlorophenyl)methyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · in 1 record
Elsewhere
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