UniProt O70348
Decapping and exoribonuclease protein (O70348)
Decapping and exoribonuclease protein (UniProt O70348), EC 3.1.13.-, 3.6.1.-: 21 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 14 pockets. Binding sites, druggability and experiment against…
- UniProt
- O70348
- Protein
- Decapping and exoribonuclease protein
- EC
- 3.1.13.-, 3.6.1.-
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 14 · 5 records with a druggable one
Structures
22 records of O70348 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3FQI | Crystal Structure of the Mouse Dom3Z | x-ray diffraction | A | — | — |
| 3FQI | Crystal structure of the mouse DOM3Z | x-ray diffraction | A | — | — |
| 3FQJ | Crystal Structure of the Mouse Dom3Z in Complex with GDP | x-ray diffraction | A | — | — |
| 3FQJ | Crystal structure of the mouse DOM3Z in complex with GDP | x-ray diffraction | A | — | — |
| 4J7L | Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions | x-ray diffraction | A | — | — |
| 4J7L | Crystal structure of mouse dxo in complex with product RNA and two magnesium ions | x-ray diffraction | A | — | — |
| 4J7M | Crystal structure of mouse DXO in complex with substrate mimic RNA and calcium ion | x-ray diffraction | A | — | — |
| 4J7M | Crystal structure of mouse dxo in complex with substrate mimic RNA and calcium ion | x-ray diffraction | A | — | — |
| 4J7N | Crystal structure of mouse DXO in complex with M7GPPPG cap | x-ray diffraction | A | — | — |
| 4J7N | Crystal structure of mouse dxo in complex with M7GPPPG cap | x-ray diffraction | A | — | — |
| 5ULI | Crystal Structure of mouse DXO in complex with (3'-NADP)+ and calcium ion | x-ray diffraction | A | CA, 0WD | 4 (best 0.77) |
| 5ULI | Crystal structure of mouse dxo in complex with (3'-NADP)+ and calcium ion | x-ray diffraction | A | CA, 0WD | — |
| 6AIX | Crystal structure of DXO in complex with adenosine 3', 5' bisphosphate and two magnesium ions | x-ray diffraction | A | A3P, MG | 3 (best 0.76) |
| 6AIX | Crystal structure of dxo in complex with adenosine 3', 5' bisphosphate and two magnesium ions | x-ray diffraction | A | A3P, MG | — |
| 6AIY | Crystal structure of dxo (E234A mutant) in complex with adenosine 3', 5' bisphosphate and two… | x-ray diffraction | A | A3P, MG | — |
| 6WRE | Crystal structure of mouse DXO in complex with 5'-OH RNA substrate mimic and calcium ion | x-ray diffraction | A | CA, U3P | 3 (best 0.79) |
| 6WRE | Crystal structure of mouse dxo in complex with 5'-oh RNA substrate mimic and calcium ion | x-ray diffraction | A | CA, U3P | — |
| 6WUF | Crystal structure of mouse DXO in complex with 3'-FADP | x-ray diffraction | A | UBG | 3 (best 0.77) |
| 6WUF | Crystal structure of mouse dxo in complex with 3'-fadp | x-ray diffraction | A | UBG | — |
| 6WUK | Crystal structure of mouse DXO in complex with CoA | x-ray diffraction | A | COA | 1 (best 0.78) |
| 6WUK | Crystal structure of mouse dxo in complex with CoA | x-ray diffraction | A | COA | — |
| O70348 | AlphaFold monomer V2.0 prediction for decapping and exoribonuclease protein (O70348) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 4 records
- A3P · Adenosine-3'-5'-diphosphate · in 3 records
- MG · Magnesium ion · in 3 records
- 0WD · [[(2R,3S,4R,5R)-5-(3-aminocarbonyl-4H-pyridin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate · in 2 records
- COA · Coenzyme A · in 2 records
- U3P · 3'-uridinemonophosphate · in 2 records
- UBG · [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) · in 2 records
Experiment against prediction
- 6WUK chain A against the predicted model O70348: TM-score 1.00, RMSD 0.22 Å
- 6WUK chain A against the predicted model O70348: TM-score 1.00, RMSD 0.22 Å
- 4J7L chain A against the predicted model O70348: TM-score 1.00, RMSD 0.24 Å
- 4J7L chain A against the predicted model O70348: TM-score 1.00, RMSD 0.24 Å
- 4J7M chain A against the predicted model O70348: TM-score 1.00, RMSD 0.23 Å
- 4J7M chain A against the predicted model O70348: TM-score 1.00, RMSD 0.23 Å
- 6AIX chain A against the predicted model O70348: TM-score 1.00, RMSD 0.24 Å
- 6AIX chain A against the predicted model O70348: TM-score 1.00, RMSD 0.24 Å
- 6WRE chain A against the predicted model O70348: TM-score 1.00, RMSD 0.26 Å
- 6WRE chain A against the predicted model O70348: TM-score 1.00, RMSD 0.26 Å
Elsewhere
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