UniProt O05000
NADH-ubiquinone oxidoreductase chain 2 (O05000)
NADH-ubiquinone oxidoreductase chain 2 (UniProt O05000), EC 7.1.1.2: 12 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 42 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O05000
- Protein
- NADH-ubiquinone oxidoreductase chain 2
- EC
- 7.1.1.2
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 42 · 9 records with a druggable one
Structures
13 records of O05000 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7AQQ | Cryo-EM structure of Arabidopsis thaliana Complex-I (membrane core) | electron microscopy | N | LMN, PTY, PC7, PGT, PSF | 8 (best 0.86) |
| 7AQQ | Cryo-EM structure of arabidopsis thaliana complex-I (membrane core) | electron microscopy | N | LMN, PTY, PC7, PGT | — |
| 7AR7 | Cryo-EM structure of Arabidopsis thaliana complex-I (open conformation) | electron microscopy | N | LMN, PTY, PC7, PGT, PSF | 4 (best 0.86) |
| 7AR7 | Cryo-EM structure of arabidopsis thaliana complex-I (open conformation) | electron microscopy | N | LMN, PTY, PC7, PGT | — |
| 7AR8 | Cryo-EM structure of Arabidopsis thaliana complex-I (closed conformation) | electron microscopy | N | PGT, PTY, LMN, PC7, PSF | 3 (best 0.86) |
| 7AR8 | Cryo-EM structure of arabidopsis thaliana complex-I (closed conformation) | electron microscopy | N | PGT, PTY, LMN, PC7 | — |
| 7ARB | Cryo-EM structure of Arabidopsis thaliana Complex-I (complete composition) | electron microscopy | N | LMN, PTY, PGT, PC7, PSF | 4 (best 0.86) |
| 7ARB | Cryo-EM structure of arabidopsis thaliana complex-I (complete composition) | electron microscopy | N | LMN, PTY, PGT, PC7 | — |
| 8BEF | Cryo-EM structure of the Arabidopsis thaliana I+III2 supercomplex (CI membrane core) | electron microscopy | N | PGT, PTY, Q7G, UQ5, PC7, 3PH | 11 (best 0.86) |
| 8BPX | Cryo-EM structure of the Arabidopsis thaliana I+III2 supercomplex (Complete composition) | electron microscopy | N | PGT, UQ5, PTY, Q7G, PC7, 3PH | 4 (best 0.86) |
| 8BQ5 | Cryo-EM structure of the Arabidopsis thaliana I+III2 supercomplex (Complete conformation 1… | electron microscopy | N | — | 2 (best 0.86) |
| 8BQ6 | Cryo-EM structure of the Arabidopsis thaliana I+III2 supercomplex (Complete conformation 2… | electron microscopy | N | — | 3 (best 0.87) |
| O05000 | AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 2 (O05000) | predicted | A | — | 3 (best 0.57) |
Ligands
- PC7 · (7S)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy) methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide · in 10 records
- PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 10 records
- PTY · Phosphatidylethanolamine · in 10 records
- LMN · Lauryl Maltose Neopentyl Glycol · in 8 records
- PSF · 1,2-dicaproyl-sn-phosphatidyl-L-serine · in 4 records
- 3PH · 1,2-diacyl-glycerol-3-sn-phosphate · in 2 records
- Q7G · 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta, 17beta,25r)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside · in 2 records
- UQ5 · 2,3-dimethoxy-5-methyl-6-(3,11,15,19-tetramethyl-eicosa-2,6,10,14,18-pentaenyl)-[1,4]benzoquinone · in 2 records
Experiment against prediction
- 7AQQ chain N against the predicted model O05000: TM-score 0.99, RMSD 0.94 Å
- 7AQQ chain N against the predicted model O05000: TM-score 0.99, RMSD 0.94 Å
- 7ARB chain N against the predicted model O05000: TM-score 0.99, RMSD 0.95 Å
- 7ARB chain N against the predicted model O05000: TM-score 0.99, RMSD 0.95 Å
- 7AR7 chain N against the predicted model O05000: TM-score 0.99, RMSD 1.02 Å
- 7AR7 chain N against the predicted model O05000: TM-score 0.99, RMSD 1.02 Å
- 7AR8 chain N against the predicted model O05000: TM-score 0.99, RMSD 1.03 Å
- 7AR8 chain N against the predicted model O05000: TM-score 0.99, RMSD 1.03 Å
- 8BQ6 chain N against the predicted model O05000: TM-score 0.98, RMSD 1.06 Å
- 8BEF chain N against the predicted model O05000: TM-score 0.98, RMSD 1.08 Å
Elsewhere
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