UniProt D0VWZ0
Tubulin alpha chain (D0VWZ0)
Tubulin alpha chain (UniProt D0VWZ0): 43 experimental structures on GenesisL1, 16 ligands bound, 516 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- D0VWZ0
- Protein
- Tubulin alpha chain
- Experimental structures
- 43
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 516 · 43 records with a druggable one
Structures
43 records of D0VWZ0 in the MolNFT archive: 43 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3N2G | TUBULIN-NSC 613863: RB3 Stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, G2N | 13 (best 0.83) |
| 3N2G | Tubulin-nsc 613863: RB3 stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, G2N | 13 (best 0.83) |
| 3N2K | TUBULIN-NSC 613862: RB3 Stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, K2N | 14 (best 0.84) |
| 3N2K | Tubulin-nsc 613862: RB3 stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, K2N | 14 (best 0.84) |
| 3RYC | Tubulin: RB3 stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, SO4 | 14 (best 0.83) |
| 3RYC | Tubulin: RB3 stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, SO4 | 14 (best 0.83) |
| 3RYF | GTP-Tubulin: RB3 Stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, SO4 | 14 (best 0.83) |
| 3RYF | GTP-tubulin: RB3 stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, SO4 | 14 (best 0.83) |
| 3RYH | GMPCPP-Tubulin: RB3 Stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, SO4 | 14 (best 0.83) |
| 3RYH | Gmpcpp-tubulin: RB3 stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, SO4 | 14 (best 0.83) |
| 3RYI | GDP-Tubulin: rb3 stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, SO4 | 14 (best 0.81) |
| 3RYI | GDP-tubulin: RB3 stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, SO4 | 14 (best 0.81) |
| 3UT5 | Tubulin-Colchicine-Ustiloxin: Stathmin-like domain complex | x-ray diffraction | A, C | GTP, MG, SO4, LOC | 16 (best 0.83) |
| 3UT5 | Tubulin-colchicine-ustiloxin: stathmin-like domain complex | x-ray diffraction | A, C | 0EA, 0E5, GTP, MG, SO4, LOC | 16 (best 0.83) |
| 4DRX | GTP-Tubulin in complex with a DARPIN | x-ray diffraction | A, C | GTP, MG | 10 (best 0.78) |
| 4DRX | GTP-tubulin in complex with a darpin | x-ray diffraction | A, C | GTP, MG | 10 (best 0.78) |
| 4EB6 | Tubulin-Vinblastine: Stathmin-like complex | x-ray diffraction | A, C | GTP, MG, SO4, VLB | 15 (best 0.82) |
| 4EB6 | Tubulin-vinblastine: stathmin-like complex | x-ray diffraction | A, C | GTP, MG, SO4, VLB | 15 (best 0.82) |
| 4F61 | Tubulin:Stathmin-like domain complex | x-ray diffraction | A, C, E, G | GTP, MG | 17 (best 0.80) |
| 4F61 | TUBULIN:STATHMIN-like domain complex | x-ray diffraction | A, C, E, G | GTP, MG | 17 (best 0.80) |
| 4F6R | Tubulin:Stathmin-like domain complex | x-ray diffraction | A | GTP, MG, SO4 | 6 (best 0.80) |
| 4F6R | TUBULIN:STATHMIN-like domain complex | x-ray diffraction | A | GTP, MG, SO4 | 6 (best 0.80) |
| 4HNA | Kinesin motor domain in the ADP-MG-ALFX state in complex with tubulin and a DARPIN | x-ray diffraction | A | GTP, MG | 5 (best 0.80) |
| 4HNA | Kinesin motor domain in the ADP-mg-alfx state in complex with tubulin and a darpin | x-ray diffraction | A | GTP, MG | 5 (best 0.80) |
| 4X1I | Discovery of cytotoxic dolastatin 10 analogs with N-terminal modifications | x-ray diffraction | A, C | GTP, MG, LOC, 3WD | 15 (best 0.84) |
| 4X1K | Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications | x-ray diffraction | A, C | GTP, MG, LOC, 3WZ | 13 (best 0.84) |
| 4X1K | Discovery of cytotoxic dolastatin 10 analogs with N-terminal modifications | x-ray diffraction | A, C | GTP, MG, LOC, 3WZ | 13 (best 0.84) |
| 4X1Y | Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications | x-ray diffraction | A, C | GTP, MG, LOC, 3WV | 14 (best 0.85) |
| 4X1Y | Discovery of cytotoxic dolastatin 10 analogs with N-terminal modifications | x-ray diffraction | A, C | GTP, MG, LOC, 3WV | 14 (best 0.85) |
| 4X20 | Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications | x-ray diffraction | A, C | GTP, MG, LOC, 3WY | 13 (best 0.85) |
| 4X20 | Discovery of cytotoxic dolastatin 10 analogs with N-terminal modifications | x-ray diffraction | A, C | GTP, MG, LOC, 3WY | 13 (best 0.85) |
| 5EYP | Tubulin-darpin complex | x-ray diffraction | A | GTP, MG, SO4, LOC | 5 (best 0.83) |
| 5EYP | Tubulin-darpin complex | x-ray diffraction | A | GTP, MG, SO4, LOC | 5 (best 0.83) |
| 5KX5 | Crystal structure of tubulin-stathmin-TTL-Compound 11 complex | x-ray diffraction | A, C | GTP, MG, CA, 6YK | 15 (best 0.83) |
| 5KX5 | Crystal structure of tubulin-stathmin-ttl-compound 11 complex | x-ray diffraction | A, C | GTP, MG, CA, 6YK | 15 (best 0.83) |
| 6GVM | Tubulin:F3II DARPin complex | x-ray diffraction | A | GTP, MG | 7 (best 0.74) |
| 6GVM | TUBULIN:F3II darpin complex | x-ray diffraction | A | GTP, MG | 7 (best 0.74) |
| 6GVN | Tubulin:TM-3 DARPin complex | x-ray diffraction | A | GTP, MG, SO4 | 8 (best 0.80) |
| 6GVN | TUBULIN:TM-3 darpin complex | x-ray diffraction | A | GTP, MG, SO4 | 8 (best 0.80) |
| 6GX7 | Tubulin-CopN-alphaRep complex | x-ray diffraction | A, C | GTP, MG, SO4 | 12 (best 0.77) |
| 6GX7 | Tubulin-copn-alpharep complex | x-ray diffraction | A, C | GTP, MG, SO4 | 12 (best 0.77) |
| 8CGZ | tubulin-AB8939 complex | x-ray diffraction | A, C | GTP, MG, UIY, SO4 | 13 (best 0.84) |
| 9F07 | TUBULIN:STATHMIN:DARPIN:TAU MTBR3 complex | x-ray diffraction | A, E | GTP, MG | 10 (best 0.81) |
Ligands
- GTP · Guanosine-5'-triphosphate · in 43 records
- MG · Magnesium ion · in 43 records
- SO4 · Sulfate ion · in 21 records
- LOC · N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide · in 11 records
- 3WV · N,2-dimethyl-L-alanyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide · in 2 records
- 3WY · 2-methyl-L-prolyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide · in 2 records
- 3WZ · 2-methyl-L-alanyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide · in 2 records
- 6YK · (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[[(2~{S},3~{S})-2-[[(2~{R})-1,2-dimethylpyrrolidin-2-yl]carbonylamino]-3-methyl-pentanoyl]-methyl-amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-aminophenyl)-2-methyl-pentanoic acid · in 2 records
- CA · Calcium ion · in 2 records
- G2N · ethyl [(2R)-5-amino-2-methyl-3-phenyl-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate · in 2 records
- K2N · ethyl [(2S)-5-amino-2-methyl-3-phenyl-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate · in 2 records
- VLB · (2alpha,2'beta,3beta,4alpha,5beta)-vincaleukoblastine · in 2 records
- 0E5 · (2S,3R)-2-azanyl-3-methyl-3-oxidanyl-pentanoic acid · in 1 record
- 0EA · (betar)-beta,3-dihydroxy-N-methyl-L-tyrosine · in 1 record
- 3WD · 2-methyl-L-alanyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide · in 1 record
- UIY · Ab-8939 · in 1 record
Elsewhere
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