UniProt C6H0Y9
Polymerase acidic protein (C6H0Y9)
Polymerase acidic protein (UniProt C6H0Y9): 64 experimental structures on GenesisL1, 28 ligands bound, 37 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- C6H0Y9
- Protein
- Polymerase acidic protein
- Experimental structures
- 64
- Predicted models
- 0
- Ligands
- 28
- Pockets
- 37 · 33 records with a druggable one
Structures
64 records of C6H0Y9 in the MolNFT archive: 64 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6NEL | 4-(2-(4-fluorophenyl)-5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzoic acid bound to influenza 2009… | x-ray diffraction | A | MN, MG, KKV, SO4 | — |
| 6NEL | 4-(2-(4-fluorophenyl)-5-hydroxy-6-oxo-1,6-dihydropyridin-3-YL)BENZOIC acid bound to influenza 2009… | x-ray diffraction | A | MN, MG, KKV, SO4 | — |
| 6NEM | 3-hydroxy-5-[(naphthalen-1-yl)methyl]-6-[4-(1H-tetrazol-5-yl)phenyl]pyridin-2(1H)-one bound to… | x-ray diffraction | A | MN, KKS, SO4 | — |
| 6NEM | 3-hydroxy-5-[(naphthalen-1-YL)METHYL]-6-[4-(1H-tetrazol-5-yl) PHENYL]PYRIDIN-2(1H)-one bound to… | x-ray diffraction | A | MN, KKS, SO4 | — |
| 6V53 | The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000985494 | x-ray diffraction | A | QPY, QQ4, MN, SO4 | 1 (best 0.61) |
| 6V53 | The crystal structure of the 2009 H1N1 pa endonuclease mutant I38T in complex with SJ000985494 | x-ray diffraction | A | QPY, QQ4, MN, SO4 | — |
| 6V56 | The crystal structure of the 2009 H1N1 PA endonuclease wild type in complex with SJ000985494 | x-ray diffraction | A | QPY, QQ4, MN, SO4 | 1 (best 0.61) |
| 6V56 | The crystal structure of the 2009 H1N1 pa endonuclease wild type in complex with SJ000985494 | x-ray diffraction | A | QPY, QQ4, MN, SO4 | — |
| 6V6X | The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000988632 | x-ray diffraction | A | MN, QQP, QQ4, SO4 | 1 (best 0.64) |
| 6V6X | The crystal structure of the 2009 H1N1 pa endonuclease mutant I38T in complex with SJ000988632 | x-ray diffraction | A | MN, QQP, QQ4, SO4 | — |
| 6V9E | The crystal structure of the 2009 H1N1 PA endonuclease wild type in complex with SJ000988632 | x-ray diffraction | A | MN, QQP, Y24, SO4 | 1 (best 0.65) |
| 6V9E | The crystal structure of the 2009 H1N1 pa endonuclease wild type in complex with SJ000988632 | x-ray diffraction | A | MN, QQP, Y24, SO4 | — |
| 6VBR | The crystal structure of the 2009 H1N1/California PA endonuclease wild type in complex with… | x-ray diffraction | A | MN, QVV, SO4 | 1 (best 0.64) |
| 6VBR | The crystal structure of the 2009 H1N1/CALIFORNIA pa endonuclease wild type in complex with… | x-ray diffraction | A | MN, QVV, SO4 | — |
| 6VG9 | The crystal structure of the 2009 H1N1/CALIFORNIA pa endonuclease I38T mutant in complex with… | x-ray diffraction | A | MN, QQ4, QVV, SO4 | — |
| 6VIV | The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000986192 | x-ray diffraction | A | QZM, QQ4, MN, SO4 | 1 (best 0.57) |
| 6VIV | The crystal structure of the 2009 H1N1 pa endonuclease mutant I38T in complex with SJ000986192 | x-ray diffraction | A | QZM, QQ4, MN, SO4 | — |
| 6VJH | The crystal structure of the 2009 H1N1/California PA endonuclease wild type in complex with… | x-ray diffraction | A | QZM, QQ4, MN | 1 (best 0.62) |
| 6VJH | The crystal structure of the 2009 H1N1/CALIFORNIA pa endonuclease wild type in complex with… | x-ray diffraction | A | QZM, QQ4, MN | — |
| 6VL3 | The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000986436 | x-ray diffraction | A | MN, R1D, QQ4, SO4 | 1 (best 0.63) |
| 6VL3 | The crystal structure of the 2009 H1N1 pa endonuclease mutant I38T in complex with SJ000986436 | x-ray diffraction | A | MN, R1D, QQ4, SO4 | — |
| 6VLL | The crystal structure of the 2009/H1N1/California PA endonuclease mutant I38T in complex with… | x-ray diffraction | A | R3J, MN, SO4 | 2 (best 0.56) |
| 6VLL | The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease mutant I38T in complex with… | x-ray diffraction | A | R3J, MN, SO4 | — |
| 6W7A | The crystal structure of the 2009/H1N1/California PA endonuclease mutant E119D bound to DNA… | x-ray diffraction | A | MN, SO4 | 2 (best 0.72) |
| 6W7A | The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease mutant E119D bound to DNA… | x-ray diffraction | A | MN, SO4 | — |
| 6WHM | The crystal structure of the 2009/H1N1/California PA endonuclease wild type bound to DNA oligomer… | x-ray diffraction | A | MG, MN, SO4 | 1 (best 0.66) |
| 6WHM | The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease wild type bound to DNA oligomer… | x-ray diffraction | A | MG, MN, SO4 | — |
| 6WIJ | The crystal structure of the 2009/H1N1/California PA endonuclease mutant I38T in complex with… | x-ray diffraction | A | MN, U3A, QQ4, SO4 | 1 (best 0.62) |
| 6WIJ | The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease mutant I38T in complex with… | x-ray diffraction | A | MN, U3A, QQ4, SO4 | — |
| 6WJ4 | The crystal structure of the 2009/H1N1/California PA endonuclease wild type in complex with… | x-ray diffraction | A | MN, U3A, QQ4, SO4 | 1 (best 0.63) |
| 6WJ4 | The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease wild type in complex with… | x-ray diffraction | A | MN, U3A, QQ4, SO4 | — |
| 6WS3 | The crystal structure of the 2009/H1N1/California PA endonuclease wild type bound to DNA oligomers… | x-ray diffraction | A | MN, SO4 | 2 (best 0.73) |
| 6WS3 | The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease wild type bound to DNA oligomers… | x-ray diffraction | A | MN, SO4 | — |
| 7K77 | The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ001008025 | x-ray diffraction | A | QQ4, MN, U3A, SO4 | — |
| 7K77 | The crystal structure of the 2009 H1N1 pa endonuclease mutant I38T in complex with SJ001008025 | x-ray diffraction | A | QQ4, MN, U3A, SO4 | — |
| 7K87 | The crystal structure of the 2009 H1N1 PA endonuclease in complex with SJ000986436 | x-ray diffraction | A | QQ4, MN, W5V | 1 (best 0.64) |
| 7K87 | The crystal structure of the 2009 H1N1 pa endonuclease in complex with SJ000986436 | x-ray diffraction | A | QQ4, MN, W5V | — |
| 7KAF | The crystal structure of the 2009/H1N1/California PA endonuclease I38T (construct with truncated… | x-ray diffraction | A | E4Z, QQ4, MN, SO4 | 1 (best 0.65) |
| 7KAF | The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease I38T (construct with truncated… | x-ray diffraction | A | E4Z, QQ4, MN, SO4 | — |
| 7KBC | The crystal structure of the 2009/H1N1/California PA endonuclease mutant E119D (construct with… | x-ray diffraction | A | E4Z, QQ4, MN, SO4 | 1 (best 0.63) |
| 7KBC | The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease mutant E119D (construct with… | x-ray diffraction | A | E4Z, QQ4, MN, SO4 | — |
| 7KNR | The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with… | x-ray diffraction | A | MN, WTD, QQ4, SO4 | 1 (best 0.62) |
| 7KNR | The crystal structure of the I38T mutant pa endonuclease (2009/H1N1/CALIFORNIA) in complex with… | x-ray diffraction | A | MN, WTD, QQ4, SO4 | — |
| 7KNY | The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with… | x-ray diffraction | A | MN, WTG, QQ4, SO4 | 1 (best 0.66) |
| 7KNY | The crystal structure of the I38T mutant pa endonuclease (2009/H1N1/CALIFORNIA) in complex with… | x-ray diffraction | A | MN, WTG, QQ4, SO4 | — |
| 7KOP | The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with… | x-ray diffraction | A | MN, WTM, QQ4, SO4 | 1 (best 0.62) |
| 7KOP | The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease I38T mutant in complex with… | x-ray diffraction | A | MN, WTM, QQ4, SO4 | — |
| 7LP7 | The crystal structure of the wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with… | x-ray diffraction | A | YAD, QQ4, MN, SO4 | 1 (best 0.63) |
| 7LP7 | The crystal structure of the wild type pa endonuclease (2009/H1N1/CALIFORNIA) in complex with… | x-ray diffraction | A | YAD, QQ4, MN, SO4 | — |
| 7LP8 | The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with… | x-ray diffraction | A | YAD, QQ4, MN, SO4 | 1 (best 0.63) |
| 7LP8 | The crystal structure of I38T mutant pa endonuclease (2009/H1N1/CALIFORNIA) in complex with… | x-ray diffraction | A | YAD, QQ4, MN, SO4 | — |
| 7LW6 | The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with… | x-ray diffraction | A | RLT, QQ4, MN, SO4 | 1 (best 0.66) |
| 7LW6 | The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease I38T mutant in complex with… | x-ray diffraction | A | RLT, QQ4, MN, SO4 | — |
| 7UMR | The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound… | x-ray diffraction | A | MN, QQ4, NVR, SO4 | 1 (best 0.64) |
| 7UUH | The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound… | x-ray diffraction | A | MN, QQ4, NVR, SO4 | 1 (best 0.65) |
| 8DIP | The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with… | x-ray diffraction | A | MN, QQ4, SE9, SO4 | 1 (best 0.65) |
| 8DPJ | The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound… | x-ray diffraction | A | MN, QQ4, SE9, SO4 | 1 (best 0.64) |
| 8DQS | The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound… | x-ray diffraction | A | MN, T8I, QQ4 | 1 (best 0.64) |
| 8DTW | The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with… | x-ray diffraction | A | MN, TLR, QQ4, SO4, MG | 1 (best 0.64) |
| 8DVO | The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound… | x-ray diffraction | A | MN, U0I, QQ4, SO4 | — |
4 records more on the page itself.
Ligands
- MN · Manganese (II) ion · in 64 records
- SO4 · Sulfate ion · in 59 records
- QQ4 · Hexa Vinylpyrrolidone K15 · in 48 records
- U3A · 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-4-carboxamide · in 6 records
- MG · Magnesium ion · in 5 records
- E4Z · Baloxavir acid · in 4 records
- QPY · Benzyl (2S)-2-(4-{[2-(6-amino-9H-purin-9-yl) ethyl]carbamoyl}-5-hydroxy-6-oxo-1,6-dihydropyrimidin-2-yl)pyrrolidine-1-carboxylate · in 4 records
- QQP · N-[2-(6-amino-9H-purin-9-yl)ethyl]-5-hydroxy-6-oxo-2-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide · in 4 records
- QZM · 2-[2-[(cyclohexylmethyl-$L^{3}-oxidanyl) carbonylamino]propan-2-yl]-~{N}-[2-(5-methoxy-4-oxidanyl-cyclohexa-1,3,5-trien-1-yl)ethyl]-5-oxidanyl-6-oxidanylidene-pyrimidine-4-carboxamide · in 4 records
- YAD · (phenylmethyl) (2~{S})-2-[5-oxidanyl-6-oxidanylidene-4-(2-pyridin-4-ylethylcarbamoyl)-1~{H}-pyrimidin-2-yl]pyrrolidine-1-carboxylate · in 4 records
- QVV · Benzyl [2-(4-{[2-(6-amino-9H-purin-9-yl) ethyl]carbamoyl}-5-hydroxy-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl]carbamate · in 3 records
- KKS · 3-hydroxy-5-[(naphthalen-1-yl)methyl]-6-[4-(1H-tetrazol-5-yl)phenyl]pyridin-2(1H)-one · in 2 records
- KKV · 4-[2-(4-fluorophenyl)-5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl]benzoic acid · in 2 records
- NVR · (1P,18Z)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2(28),5,11(27),12,14,18,22,24-nonaene-4,7-dione · in 2 records
- R1D · 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide · in 2 records
- R3J · Benzyl [2-(5-hydroxy-4-{[2-(2-methoxypyridin-4-yl) ethyl]carbamoyl}-6-oxo-1,6-dihydropyrimidin-2-yl) propan-2-yl]carbamate · in 2 records
- RLT · N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl) carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide · in 2 records
- SE9 · (2P)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide · in 2 records
- U0I · 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-1,6-dihydropyrimidine-4-carboxamide · in 2 records
- U9U · 5-hydroxy-6-oxo-N-[2-(pyridin-4-yl)ethyl]-2-{[2-(trifluoromethyl)phenyl]methyl}-3,6-dihydropyrimidine-4-carboxamide · in 2 records
- W5V · 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide · in 2 records
- WTD · 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide · in 2 records
- WTG · 2-(2-fluorophenyl)-5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide · in 2 records
- WTM · 2-(2-fluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-1,6-dihydropyrimidine-4-carboxamide · in 2 records
- Y24 · 1,1',1'',1''',1''''-[(3R,5S,7S,9R)-decane-1,3,5,7,9-pentayl]penta(pyrrolidin-2-one) · in 2 records
- T8I · 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[4-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-4-carboxamide · in 1 record
- TLR · 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-1,6-dihydropyrimidine-4-carboxamide · in 1 record
- WFW · benzyl [2-(6-{[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]carbamoyl}-5-hydroxy-4-oxo-1,4-dihydropyrimidin-2-yl)propan-2-yl]carbamate · in 1 record
Elsewhere
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