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Ligand · E4Z

E4Z · Baloxavir acid

E4Z, Baloxavir acid (C24 H19 F2 N3 O4 S, 483.5 g/mol), in the MolNFT structures on GenesisL1: bound in 9 records (8 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
E4Z
Formula
C24 H19 F2 N3 O4 S
Class
ligand
Structures
9
PDB entries
8

Binding sites

E4Z in 9 structures; the first of them:

  • 6FS6 · Influenza A/California/04/2009 (pH1N1) endonuclease with bound inhibitor, baloxavir acid… · E4Z A903 · binds ALA20, MET21, TYR24, GLU26, LYS34, ALA37, ILE38, HIS41 and 7 more
  • 7PLR · Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein… · E4Z AAA201 · binds VAL27, LEU30, MET31, HIS34, ASP52, ASP79, ASP92, TYR93 and 1 more
  • 6FS6 · Influenza A/CALIFORNIA/04/2009 (PH1N1) endonuclease with bound inhibitor, baloxavir acid… · E4Z A903 · binds ALA20, MET21, TYR24, GLU26, LYS34, ALA37, ILE38, HIS41 and 7 more
  • 6FS7 · Influenza A/CALIFORNIA/04/2009 (PH1N1) endonuclease with I38T mutation with bound… · E4Z A903 · binds ALA20, MET21, TYR24, GLU26, LYS34, ALA37, THR38, HIS41 and 7 more
  • 6FS8 · Influenza B/MEMPHIS/13/03 endonuclease with bound inhibitor, baloxavir acid (bxa) · E4Z B201 · binds THR20, PHE24, GLU26, MET34, ASN37, ILE38, HIS41, GLU81 and 6 more
  • 6FS9 · Influenza B/MEMPHIS/13/03 endonuclease with I38T mutation with bound inhibitor, baloxavir… · E4Z A203 · binds THR20, MET21, PHE24, GLU26, MET34, ASN37, THR38, HIS41 and 7 more
  • 7K0W · The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease (construct with… · E4Z A201 · binds ALA20, MET21, TYR24, GLU26, LYS34, ALA37, ILE38, HIS41 and 6 more
  • 7KAF · The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease I38T (construct with… · E4Z A201 · binds ALA20, MET21, TYR24, GLU26, LYS34, ALA37, THR38, HIS41 and 6 more
  • 7KBC · The crystal structure of the 2009/H1N1/CALIFORNIA pa endonuclease mutant E119D (construct… · E4Z A201 · binds ALA20, MET21, TYR24, GLU26, LYS34, ALA37, ILE38, HIS41 and 5 more

Residues it binds most

GLU 24, LYS 27, TYR 27, ALA 21, ILE 23, ASP 27, MET 27, HIS 27, THR 10, VAL 6 (residue and the binding sites it lines).

Found with

  • MN · Manganese (II) ion
  • SO4 · Sulfate ion
  • QQ4 · Hexa Vinylpyrrolidone K15
  • GOL · Glycerol
  • CL · Chloride ion
  • FMT · Formic acid

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