UniProt B3Y653
Toll-like receptor 7 (B3Y653)
Toll-like receptor 7 (UniProt B3Y653): 42 experimental structures on GenesisL1, 20 ligands bound, 346 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- B3Y653
- Protein
- Toll-like receptor 7
- Experimental structures
- 42
- Predicted models
- 0
- Ligands
- 20
- Pockets
- 346 · 19 records with a druggable one
Structures
42 records of B3Y653 in the MolNFT archive: 42 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GMF | Crystal structure of monkey TLR7 in complex with guanosine and polyu | x-ray diffraction | A, B, C, D | — | — |
| 5GMG | Crystal structure of monkey TLR7 in complex with loxoribine and polyu | x-ray diffraction | A, B | — | — |
| 5GMH | Crystal structure of monkey TLR7 in complex with R848 | x-ray diffraction | A, B | NAG, RX8, SO4 | 20 (best 0.70) |
| 5GMH | Crystal structure of monkey TLR7 in complex with R848 | x-ray diffraction | A, B | — | — |
| 5ZSA | Crystal structure of monkey TLR7 in complex with IMDQ and UUUUUU | x-ray diffraction | B, A | NAG, IDQ, SO4 | 19 (best 0.71) |
| 5ZSA | Crystal structure of monkey TLR7 in complex with imdq and uuuuuu | x-ray diffraction | B, A | NAG, IDQ, SO4 | — |
| 5ZSB | Crystal structure of monkey TLR7 in complex with IMDQ and AAUUAA | x-ray diffraction | B, A | NAG, IDQ, SO4 | 20 (best 0.70) |
| 5ZSB | Crystal structure of monkey TLR7 in complex with imdq and aauuaa | x-ray diffraction | B, A | NAG, IDQ, SO4 | — |
| 5ZSC | Crystal structure of monkey TLR7 in complex with IMDQ and CCUUCC | x-ray diffraction | B, A | NAG, IDQ, SO4 | 20 (best 0.71) |
| 5ZSC | Crystal structure of monkey TLR7 in complex with imdq and ccuucc | x-ray diffraction | B, A | NAG, IDQ, SO4 | — |
| 5ZSD | Crystal structure of monkey TLR7 in complex with IMDQ and GGUUGG | x-ray diffraction | B, A | NAG, IDQ, SO4 | 20 (best 0.71) |
| 5ZSD | Crystal structure of monkey TLR7 in complex with imdq and gguugg | x-ray diffraction | B, A | NAG, IDQ, SO4 | — |
| 5ZSE | Crystal structure of monkey TLR7 in complex with IMDQ and GGUCCC | x-ray diffraction | B, A | NAG, IDQ, SO4 | 20 (best 0.69) |
| 5ZSE | Crystal structure of monkey TLR7 in complex with imdq and gguccc | x-ray diffraction | B, A | NAG, IDQ, SO4 | — |
| 5ZSF | Crystal structure of monkey TLR7 in complex with imiquimod | x-ray diffraction | B, A | NAG, SO4, 6T0 | — |
| 5ZSF | Crystal structure of monkey TLR7 in complex with imiquimod | x-ray diffraction | B, A | NAG, SO4, 6T0 | — |
| 5ZSH | Crystal structure of monkey TLR7 in complex with CL075 | x-ray diffraction | B, A | NAG, SO4, L07 | 20 (best 0.69) |
| 5ZSH | Crystal structure of monkey TLR7 in complex with CL075 | x-ray diffraction | B, A | NAG, SO4, L07 | — |
| 5ZSI | Crystal structure of monkey TLR7 in complex with CL097 | x-ray diffraction | B, A | NAG, C09, SO4 | 20 (best 0.71) |
| 5ZSI | Crystal structure of monkey TLR7 in complex with CL097 | x-ray diffraction | B, A | NAG, C09, SO4 | — |
| 5ZSJ | Crystal structure of monkey TLR7 in complex with GS9620 | x-ray diffraction | A, B | NAG, 9JR, SO4 | 20 (best 0.72) |
| 5ZSJ | Crystal structure of monkey TLR7 in complex with GS9620 | x-ray diffraction | A, B | NAG, 9JR, SO4 | — |
| 5ZSL | Crystal structure of monkey TLR7 in complex with GGUUGG | x-ray diffraction | B, A | NAG, SO4, 9K9 | — |
| 5ZSL | Crystal structure of monkey TLR7 in complex with gguugg | x-ray diffraction | B, A | NAG, SO4, 9K9 | — |
| 5ZSM | Crystal structure of monkey TLR7 in complex with GGUCCC | x-ray diffraction | B, A | NAG, SO4, 9K9 | 20 (best 0.70) |
| 5ZSM | Crystal structure of monkey TLR7 in complex with gguccc | x-ray diffraction | B, A | NAG, SO4, 9K9 | — |
| 5ZSN | Crystal structure of monkey TLR7 in complex with AAUUAA | x-ray diffraction | B, A | NAG, BMA, PO4, SO4, ACK | 17 (best 0.71) |
| 5ZSN | Crystal structure of monkey TLR7 in complex with aauuaa | x-ray diffraction | B, A | NAG, BMA, PO4, SO4, ACK | — |
| 6IF5 | Crystal structure of monkey TLR7 in complex with 2',3'-cGMP (Guanosine 2',3'-cyclic phosphate) | x-ray diffraction | B, A | NAG, SO4, 23G | 20 (best 0.73) |
| 6IF5 | Crystal structure of monkey TLR7 in complex with 2',3'-cgmp (guanosine 2',3'-cyclic phosphate) | x-ray diffraction | B, A | NAG, SO4, 23G | — |
| 6LVX | Crystal structure of TLR7/Cpd-1 (SM-374527) complex | x-ray diffraction | A, B | NAG, EWL, SO4 | 18 (best 0.70) |
| 6LVX | Crystal structure of TLR7/CPD-1 (sm-374527) complex | x-ray diffraction | A, B | NAG, EWL, SO4 | — |
| 6LVY | Crystal structure of TLR7/Cpd-2 (SM-360320) complex | x-ray diffraction | A, B | NAG, EWU, SO4 | 18 (best 0.70) |
| 6LVY | Crystal structure of TLR7/CPD-2 (sm-360320) complex | x-ray diffraction | A, B | NAG, EWU, SO4 | — |
| 6LVZ | Crystal structure of TLR7/Cpd-3 (SM-394830) complex | x-ray diffraction | B, A | NAG, SO4, EWX | 20 (best 0.69) |
| 6LVZ | Crystal structure of TLR7/CPD-3 (sm-394830) complex | x-ray diffraction | B, A | NAG, SO4, EWX | — |
| 6LW0 | Crystal structure of TLR7/Cpd-6 (DSR-139293) complex | x-ray diffraction | B, A | NAG, SO4, EX0 | 20 (best 0.70) |
| 6LW0 | Crystal structure of TLR7/CPD-6 (dsr-139293) complex | x-ray diffraction | B, A | NAG, SO4, EX0 | — |
| 6LW1 | Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form | electron microscopy | A, B | EX3 | 10 (best 0.75) |
| 6LW1 | Cryo-EM structure of TLR7/CPD-7 (dsr-139970) complex in open form | electron microscopy | A, B | EX3 | — |
| 7YTP | TLR7 in complex with an inhibitor | electron microscopy | A, B | NAG, JRI | 9 (best 0.74) |
| 8I96 | Cryo-EM structure of TLR7/TH-407b complex | electron microscopy | B, A | GJX | 15 (best 0.74) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 36 records
- SO4 · Sulfate ion · in 35 records
- IDQ · 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine · in 10 records
- 9K9 · 2-amino-9-[(2s,3ar,4r,6r,6ar)-2-hydroxy-6-(hydroxymethyl)-2-oxotetrahydro-2H-2lambda~5~-furo[3, 4-d][1,3,2]dioxaphosphol-4-yl]-3,9-dihydro-6H-purin-6-one · in 4 records
- 23G · Guanosine-5'-phosphate-2',3'-cyclic phosphate · in 2 records
- 6T0 · 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine · in 2 records
- 9JR · 4-azanyl-2-butoxy-8-[[3-(pyrrolidin-1-ylmethyl) phenyl]methyl]-5,7-dihydropteridin-6-one · in 2 records
- ACK · 2',3'- cyclic AMP · in 2 records
- BMA · beta-D-mannopyranose · in 2 records
- C09 · 2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine · in 2 records
- EWL · 6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one · in 2 records
- EWU · 6-azanyl-2-(2-methoxyethoxy)-9-(phenylmethyl)-7H-purin-8-one · in 2 records
- EWX · 6-azanyl-2-(2-methoxyethoxy)-9-(pyridin-3-ylmethyl)-7H-purin-8-one · in 2 records
- EX0 · 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purin-6-amine · in 2 records
- EX3 · 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine · in 2 records
- L07 · 2-propyl[1,3]thiazolo[4,5-c]quinolin-4-amine · in 2 records
- PO4 · Phosphate ion · in 2 records
- GJX · (1S,3R)-5-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]carbonyladamantan-2-one · in 1 record
- JRI · (2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide · in 1 record
- RX8 · 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.