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Ligand · RX8

RX8 · 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol

RX8, 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol (C17 H22 N4 O2, 314.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding site with its residues within 4.5…

Component
RX8
Formula
C17 H22 N4 O2
Class
ligand
Structures
2
PDB entries
2

Binding sites

RX8 in 2 structures; the first of them:

  • 5ANS · Potent and selective inhibitors of MTH1 probe its role in cancer cell survival · RX8 A1157 · binds TYR7, THR8, LEU9, LYS23, ASN33, GLY34, PHE35, GLY36 and 12 more
  • 5GMH · Crystal structure of monkey TLR7 in complex with R848 · RX8 A901 · binds THR532, ASP555, LEU557, GLY584, ILE585, THR586, TYR264, ASN265 and 9 more

Residues it binds most

PHE 3, GLY 3, THR 3, TYR 3, VAL 3, ASP 3, ASN 3, LEU 3, LYS 3, GLN 2 (residue and the binding sites it lines).

Found with

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • SO4 · Sulfate ion

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