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Ligand · 6T0

6T0 · 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine

6T0, 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine (C14 H16 N4, 240.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and…

Component
6T0
Formula
C14 H16 N4
Class
ligand
Structures
4
PDB entries
2

Binding sites

6T0 in 4 structures; the first of them:

  • 5LBT · Structure of the human qui reductase 2 (NQO2) in complex with imiquimod · 6T0 A303 · binds PHE126, ILE128, PHE131, GLY174, PHE178, TRP105, PHE106, GLY149 and 4 more
  • 5ZSF · Crystal structure of monkey TLR7 in complex with imiquimod · 6T0 B913 · binds THR532, ASP555, LEU557, ILE585, THR586, PHE351, GLN354, VAL355 and 4 more
  • 5LBT · Structure of the human quinone reductase 2 (NQO2) in complex with imiquimod · 6T0 A303 · binds PHE126, ILE128, GLY174, PHE178, TRP105, PHE106, GLY149, GLY150 and 2 more
  • 5ZSF · Crystal structure of monkey TLR7 in complex with imiquimod · 6T0 B913 · binds THR532, ASP555, LEU557, ILE585, THR586, PHE351, GLN354, VAL355 and 4 more

Residues it binds most

PHE 8, GLY 4, ASP 8, ILE 8, THR 4, VAL 6, ASN 5, TYR 5, GLN 4, LEU 4 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • FAD · Flavin-adenine dinucleotide
  • ZN · Zinc ion
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose

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