UniProt A7MB62
Actin-related protein 2 (A7MB62)
Actin-related protein 2 (UniProt A7MB62): 40 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- A7MB62
- Protein
- Actin-related protein 2
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 27 · 5 records with a druggable one
Structures
41 records of A7MB62 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1K8K | Crystal Structure of Arp2/3 Complex | x-ray diffraction | B | — | — |
| 1K8K | Crystal structure of ARP2/3 complex | x-ray diffraction | B | — | — |
| 2P9I | Crystal Structure of bovine Arp2/3 Complex co-crystallized with ADP and crosslinked with… | x-ray diffraction | B | — | — |
| 2P9I | Crystal structure of bovine ARP2/3 complex co-crystallized with ADP and crosslinked with… | x-ray diffraction | B | — | — |
| 2P9K | Crystal structure of bovine Arp2/3 complex co-crystallized with ATP and crosslinked with… | x-ray diffraction | B | — | — |
| 2P9K | Crystal structure of bovine ARP2/3 complex co-crystallized with ATP and crosslinked with… | x-ray diffraction | B | — | — |
| 2P9L | Crystal Structure of bovine Arp2/3 complex | x-ray diffraction | B | — | — |
| 2P9L | Crystal structure of bovine ARP2/3 complex | x-ray diffraction | B | — | — |
| 2P9N | Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP | x-ray diffraction | B | — | — |
| 2P9N | Crystal structure of bovine ARP2/3 complex co-crystallized with ADP | x-ray diffraction | B | — | — |
| 2P9P | Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP | x-ray diffraction | B | — | — |
| 2P9P | Crystal structure of bovine ARP2/3 complex co-crystallized with ADP | x-ray diffraction | B | — | — |
| 2P9S | Structure of bovine Arp2/3 complex co-crystallized with ATP/Mg2+ | x-ray diffraction | B | — | — |
| 2P9S | Structure of bovine ARP2/3 complex co-crystallized with ATP/MG2+ | x-ray diffraction | B | — | — |
| 2P9U | Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium | x-ray diffraction | B | — | — |
| 2P9U | Crystal structure of bovine ARP2/3 complex co-crystallized with AMP- pnp and calcium | x-ray diffraction | B | — | — |
| 3DXK | Structure of Bos Taurus Arp2/3 Complex with Bound Inhibitor CK0944636 | x-ray diffraction | B | — | — |
| 3DXK | Structure of bos taurus ARP2/3 complex with bound inhibitor CK0944636 | x-ray diffraction | B | — | — |
| 3DXM | Structure of Bos taurus Arp2/3 Complex with Bound Inhibitor CK0993548 | x-ray diffraction | B | — | — |
| 3DXM | Structure of bos taurus ARP2/3 complex with bound inhibitor CK0993548 | x-ray diffraction | B | — | — |
| 3RSE | Structural and biochemical characterization of two binding sites for nucleation promoting factor… | x-ray diffraction | B | — | — |
| 3RSE | Structural and biochemical characterization of two binding sites for nucleation promoting factor… | x-ray diffraction | B | — | — |
| 3UKR | Crystal structure of Bos taurus Arp2/3 complex with bound inhibitor CK-666 | x-ray diffraction | B | — | — |
| 3UKR | Crystal structure of bos taurus ARP2/3 complex with bound inhibitor ck-666 | x-ray diffraction | B | — | — |
| 3UKU | Structure of Arp2/3 complex with bound inhibitor CK-869 | x-ray diffraction | B | — | — |
| 3UKU | Structure of ARP2/3 complex with bound inhibitor ck-869 | x-ray diffraction | B | — | — |
| 3ULE | Structure of Bos taurus Arp2/3 complex with bound inhibitor CK-869 and ATP | x-ray diffraction | B | — | — |
| 3ULE | Structure of bos taurus ARP2/3 complex with bound inhibitor ck-869 and ATP | x-ray diffraction | B | — | — |
| 4JD2 | Crystal structure of Bos taurus Arp2/3 complex binding with Mus musculus GMF | x-ray diffraction | B | — | — |
| 4JD2 | Crystal structure of bos taurus ARP2/3 complex binding with mus musculus gmf | x-ray diffraction | B | — | — |
| 4XEI | Orthorhombic isomorph of bovine Arp2/3 complex | x-ray diffraction | B | — | 5 (best 0.84) |
| 4XEI | Orthorhombic isomorph of bovine ARP2/3 complex | x-ray diffraction | B | — | — |
| 4XF2 | Tetragonal structure of ARP2/3 complex | x-ray diffraction | B, U | — | — |
| 6DEC | Crystal structure of Bos taurus Arp2/3 complex binding with C-terminus of Homo sapiens SPIN90 | x-ray diffraction | B, I | ATP, CA | 6 (best 0.83) |
| 6DEC | Crystal structure of bos taurus ARP2/3 complex binding with C-terminus of homo sapiens SPIN90 | x-ray diffraction | B, I | ATP | — |
| 7JPN | Cryo-EM structure of Arpin-bound Arp2/3 complex | electron microscopy | B | MG, ATP | 6 (best 0.80) |
| 7JPN | Cryo-EM structure of arpin-bound ARP2/3 complex | electron microscopy | B | MG, ATP | — |
| 7TPT | Single-particle Cryo-EM structure of Arp2/3 complex at branched-actin junction. | electron microscopy | B | MG, ADP | 2 (best 0.89) |
| 7TPT | Single-particle cryo-EM structure of ARP2/3 complex at branched-actin junction. | electron microscopy | B | MG, ADP | — |
| 8TAH | Cryo-EM structure of Cortactin-bound to Arp2/3 complex | electron microscopy | B | MG, ATP | 8 (best 0.76) |
| A7MB62 | AlphaFold monomer V2.0 prediction for actin-related protein 2 (A7MB62) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2P9P chain B against the predicted model A7MB62: TM-score 0.98, RMSD 0.70 Å
- 2P9P chain B against the predicted model A7MB62: TM-score 0.98, RMSD 0.70 Å
- 2P9K chain B against the predicted model A7MB62: TM-score 0.98, RMSD 0.84 Å
- 2P9K chain B against the predicted model A7MB62: TM-score 0.98, RMSD 0.84 Å
- 2P9L chain B against the predicted model A7MB62: TM-score 0.98, RMSD 0.75 Å
- 2P9L chain B against the predicted model A7MB62: TM-score 0.98, RMSD 0.75 Å
- 3ULE chain B against the predicted model A7MB62: TM-score 0.98, RMSD 0.80 Å
- 3ULE chain B against the predicted model A7MB62: TM-score 0.98, RMSD 0.80 Å
- 2P9S chain B against the predicted model A7MB62: TM-score 0.98, RMSD 0.75 Å
- 2P9S chain B against the predicted model A7MB62: TM-score 0.98, RMSD 0.75 Å
Elsewhere
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