MolNFT v1 · #77890 · protein
Structural and biochemical characterization of two binding sites for nucleation promoting factor wasp-vca on ARP2/3 complex
3RSE · Actin-related protein 3: “Structural and biochemical characterization of two binding sites for nucleation promoting factor wasp-vca on…”. X-ray diffraction, 20 pockets (best druggability 0.83). MolNFT v1 #77890 on GenesisL1: 3D…
- PDB
- 3RSE
- Type
- protein
- Length
- 1,705 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin-related protein 3; Actin-related protein 2; Actin-related protein 2/3 complex…
- UniProt
- P61157, A7MB62, Q58CQ2, Q3MHR7, Q3T035, Q148J6, Q3SYX9
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 8 distinct chains · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Actin-related protein 3 | protein | 396 | 45% helix, 18% strand | P61157 |
| B | Actin-related protein 2 | protein | 196 | 43% helix, 14% strand | A7MB62 |
| C | Actin-related protein 2/3 complex subunit 1B | protein | 354 | 5% helix, 49% strand | Q58CQ2 |
| D | Actin-related protein 2/3 complex subunit 2 | protein | 280 | 45% helix, 21% strand | Q3MHR7 |
| E | Actin-related protein 2/3 complex subunit 3 | protein | 173 | 48% helix, 2% strand | Q3T035 |
| F | Actin-related protein 2/3 complex subunit 4 | protein | 167 | 51% helix, 16% strand | Q148J6 |
| G | Actin-related protein 2/3 complex subunit 5 | protein | 136 | 66% helix, 0% strand | Q3SYX9 |
| Z | Ca fragment of bos taurus N-wasp | protein | 3 | 0% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 698 | 0.83 | 0.87 | 68 | empty |
| 2 | 244 | 0.79 | 0.91 | 44 | empty |
| 3 | 93 | 0.77 | 0.97 | 23 | empty |
| 4 | 517 | 0.75 | 0.83 | 54 | empty |
| 5 | 599 | 0.72 | 0.80 | 59 | empty |
Interfaces
13 interfaces between chains.
- D–F · 2267 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 1723 Ų buried · 28 hydrogen bonds · protein-protein
- C–F · 1214 Ų buried · 13 hydrogen bonds · protein-protein
- A–E · 944 Ų buried · 14 hydrogen bonds · protein-protein
- F–G · 942 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3RSE · Structural and biochemical characterization of two binding sites for nucleation promoting… · the same entry in another collection · chain Z against Z, TM-score 1.00
- Q58CQ2 · AlphaFold monomer V2.0 prediction for actin-related protein 2/3 complex subunit 1B… · a predicted model of the same protein · chain C against A, TM-score 0.99
- Q3MHR7 · AlphaFold monomer V2.0 prediction for actin-related protein 2/3 complex subunit 2 (Q3MHR7) · a predicted model of the same protein · chain D against A, TM-score 0.99
- Q3T035 · AlphaFold monomer V2.0 prediction for actin-related protein 2/3 complex subunit 3 (Q3T035) · a predicted model of the same protein · chain E against A, TM-score 0.98
- Q3SYX9 · AlphaFold monomer V2.0 prediction for actin-related protein 2/3 complex subunit 5 (Q3SYX9) · a predicted model of the same protein · chain G against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61157
- Every structure of UniProt A7MB62
- Every structure of UniProt Q58CQ2
- Every structure of UniProt Q3MHR7
- Every structure of UniProt Q3T035
- Every structure of UniProt Q148J6
- Every structure of UniProt Q3SYX9
- Elsewhere: RCSB PDB 3RSE · PDBe 3RSE · UniProt P61157 · UniProt A7MB62 · UniProt Q58CQ2 · UniProt Q3MHR7 · UniProt Q3T035 · UniProt Q148J6 · UniProt Q3SYX9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.