MolNFT v1 · #109856 · protein
Tetragonal structure of ARP2/3 complex
4XF2 · Actin-related protein 3: “Tetragonal structure of ARP2/3 complex”. X-ray diffraction, 20 pockets (best druggability 0.86). MolNFT v1 #109856 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4XF2
- Type
- protein
- Length
- 3,476 residues
- Chains
- 14
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin-related protein 3; Actin-related protein 2; Actin-related protein 2/3 complex…
- UniProt
- P61157, A7MB62, Q58CQ2, Q3MHR7, Q3T035, Q148J6, Q3SYX9
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 7 distinct chains · 28% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, T | Actin-related protein 3 | protein | 392 | 34% helix, 10% strand | P61157 |
| B, U | Actin-related protein 2 | protein | 228 | 26% helix, 4% strand | A7MB62 |
| C, V | Actin-related protein 2/3 complex subunit 1B | protein | 354 | 3% helix, 25% strand | Q58CQ2 |
| D, W | Actin-related protein 2/3 complex subunit 2 | protein | 284 | 38% helix, 10% strand | Q3MHR7 |
| E, X | Actin-related protein 2/3 complex subunit 3 | protein | 174 | 36% helix, 0% strand | Q3T035 |
| F, Y | Actin-related protein 2/3 complex subunit 4 | protein | 167 | 40% helix, 11% strand | Q148J6 |
| G, Z | Actin-related protein 2/3 complex subunit 5 | protein | 139 | 37% helix, 0% strand | Q3SYX9 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1045 | 0.86 | 0.87 | 120 | empty |
| 2 | 1165 | 0.86 | 0.87 | 126 | empty |
| 3 | 167 | 0.80 | 0.95 | 39 | empty |
| 4 | 597 | 0.79 | 0.85 | 82 | empty |
| 5 | 123 | 0.79 | 0.97 | 39 | empty |
Interfaces
26 interfaces between chains.
- D–F · 2143 Ų buried · 12 hydrogen bonds · protein-protein
- W–Y · 2125 Ų buried · 10 hydrogen bonds · protein-protein
- T–W · 1766 Ų buried · 19 hydrogen bonds · protein-protein
- A–D · 1743 Ų buried · 11 hydrogen bonds · protein-protein
- C–F · 1172 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4XF2 · Tetragonal structure of Arp2/3 complex · the same entry in another collection · chain V against V, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61157
- Every structure of UniProt A7MB62
- Every structure of UniProt Q58CQ2
- Every structure of UniProt Q3MHR7
- Every structure of UniProt Q3T035
- Every structure of UniProt Q148J6
- Every structure of UniProt Q3SYX9
- Elsewhere: RCSB PDB 4XF2 · PDBe 4XF2 · UniProt P61157 · UniProt A7MB62 · UniProt Q58CQ2 · UniProt Q3MHR7 · UniProt Q3T035 · UniProt Q148J6 · UniProt Q3SYX9
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